Interleukin (IL)-6, Interleukin (IL)-8 Levels and Cellular Composition of the Vitreous Humor in Proliferative Diabetic Retinopathy, Proliferative Vitreoretinopathy, and Traumatic Proliferative Vitreoretinopathy

Canataroglu, Hatice; Varinli, Ilter; Özcan, Altan Atakan; Canataroğlu, Abdullah; Doran, Figen; Varinli, Seyhan

doi:10.1080/09273940490518900

Cited by 100 publications

(69 citation statements)

References 17 publications

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“…Rhegmatogenous retinal detachments allow mislocalization of cells (retinal pigment epithelial cells, glial cells, and fibroblasts) into vitreous (11,12,16,52). These cells proliferate, deposit extracellular matrix, and assemble into a membrane that physically associates with the retina.…”

mentioning

confidence: 99%

Vascular Endothelial Growth Factor A Competitively Inhibits Platelet-Derived Growth Factor (PDGF)-Dependent Activation of PDGF Receptor and Subsequent Signaling Events and Cellular Responses

Pennock

Kazlauskas

2012

Molecular and Cellular Biology

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Certain platelet-derived growth factor (PDGF) isoforms are associated with proliferative vitreoretinopathy (PVR), a sightthreatening complication that develops in a subset of patients recovering from retinal reattachment surgery. Although these PDGF isoforms are abundant in the vitreous of patients and experimental animals with PVR, they make only a minor contribution to activating PDGF receptor ␣ (PDGFR␣) and driving experimental PVR. Rather, growth factors outside of the PDGF family are the primary (and indirect) agonists of PDGFR␣. These observations beg the question of why vitreal PDGFs fail to activate PDGFR␣. We report here that vitreous contains an inhibitor of PDGF-dependent activation of PDGFR␣ and that a major portion of this inhibitory activity is due to vascular endothelial cell growth factor A (VEGF-A). Furthermore, recombinant VEGF-A competitively blocks PDGF-dependent binding and activation of PDGFR, signaling events, and cellular responses. These findings unveil a previously unappreciated relationship between distant members of the PDGF/VEGF family that may contribute to pathogenesis of a blinding eye disease.

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mentioning

confidence: 99%

Vascular Endothelial Growth Factor A Competitively Inhibits Platelet-Derived Growth Factor (PDGF)-Dependent Activation of PDGF Receptor and Subsequent Signaling Events and Cellular Responses

Pennock

Kazlauskas

2012

Molecular and Cellular Biology

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“…Yoshimura et al [25] have reported the increased levels of vitreal VEGF, IL-6, IL-8 and MCP-1 in PDR. Previous studies also reported increased vitreous levels of VEGF [26,27], IL-6 [21][22][23]25,27], IL-8 [23][24][25]28], and MCP-1 [25,26,28] in PDR.…”

Section: Discussionmentioning

confidence: 72%

“…IL-8 is an inflammatory and angiogenic mediator. Increased vitreous leves of IL-6 and IL-8 correlate with disease severity as discussed by Canataroglu et al [23]. However, Petrovic et al [24] stated that increased vitreous levels of IL-8 is not associated with active PDR.…”

Section: Discussionmentioning

confidence: 98%

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Effect of Adipose Tissue-Derived Inflammatory and Proangiogenic Cytokines on Proliferative Diabetic Retinopathy

Yabanoglu¹

2014

Turk J Bioch

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Objective: To determine the vitreous and serum concentrations of TNF-α, IL-6, VEGF, IL-1β, IL-8, IL-17, MCP-1, IL-1Ra, IL-10 in patients with proliferative diabetic retinopathy (PDR) and to investigate the effect of adipose tissue on the pathogenesis of PDR. Methods: Twenty-two patients with PDR were prospectively evaluated. Seven cadavers and 11 patients with idiopathic epiretinal membrane or macular hole served as the controls. Multiplex bead array technology was employed to assess the concentrations of the cytokines. Results: The intravitreal levels of VEGF, IL-8, IL-6 were significantly higher in PDR group than control groups. In PDR group, the levels of IL-17, IL-8, IL-6 were significantly elevated in the vitreous, whereas the intravitreal levels of IL-10, IL-1Ra were found to be significantly lower than the serum concentrations. No significant correlation was found between cytokine levels and body mass index (BMI), fasting blood glucose (FBG), or glycated haemoglobin (HbA1c) of diabetic patients. Conclusion:In PDR the balance between the intravitreal pro-and anti-inflammatory adipocytokines is disturbed in favor of proinflammatory and proangiogenic cytokines in the vitreous humour. This study supports the role of adipocytokines in vascular pathology in PDR. It seems that PDR is a local inflammatory disease. However, obesity may not be the root of the inflammatory mediators in PDR.

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“…Dysfunctional barriers permit inflammatory molecules and immune cells from systemic circulation to enter the retina and cause further deterioration of the tissue [6,11]. Cytological examination of the vitreous samples from PDR patients were found to contain significant amounts of macrophages suggesting the infiltration of systemic immune cells into the retina [12,13]. In addition, there was an increase in adhesion molecule expression and pro-inflammatory cytokine production, suggesting the role of defective neutrophil activity in the development of chronic inflammation in diabetic retinopathy [14,15] (Figure 1).…”

Section: The Immune System In Proliferative Diabetic Retinopathymentioning

confidence: 99%

Proliferative Diabetic Retinopathy: An Overview of Vitreous Immune and Biomarkers

Victor¹,

Sitompul²

2018

Early Events in Diabetic Retinopathy and Intervention Strategies

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This chapter discusses about the effect of vitreous immune system and biomarkers on the progression of proliferative diabetic retinopathy. Immune system and biomarkers have been believed to have an important role in the progression of diabetic retinopathy (DR) severity. Hyperglycemic will influence immune cells resulting in chronic inflammation on the retina. This condition progressively disrupts the blood-retinal barrier in retina causing those inflammatory molecules and immune cells to transfer from circulation. The transfer of these molecules plays an important part in the progression of proliferative diabetic retinopathy. In addition, biomarkers are indicators for some complex processes happened in our body, and are measured to determine diagnosis and prognosis of some treatment. There are several biomarkers that have been identified in DR patients including biomarkers of oxidative stress, hypoxia-inducible factors, angiogenic factors, pro-inflammatory cytokines, chemokines, cell adhesion molecules, and soluble CD200. The value of these biomarkers will tell us their possible role in the progression of DR. By improving the knowledge of molecular pathway in DR pathophysiology, the advancement of selective therapy approaches could be discovered and the management of DR could be more efficient.

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Interleukin (IL)-6, Interleukin (IL)-8 Levels and Cellular Composition of the Vitreous Humor in Proliferative Diabetic Retinopathy, Proliferative Vitreoretinopathy, and Traumatic Proliferative Vitreoretinopathy

Cited by 100 publications

References 17 publications

Vascular Endothelial Growth Factor A Competitively Inhibits Platelet-Derived Growth Factor (PDGF)-Dependent Activation of PDGF Receptor and Subsequent Signaling Events and Cellular Responses

Vascular Endothelial Growth Factor A Competitively Inhibits Platelet-Derived Growth Factor (PDGF)-Dependent Activation of PDGF Receptor and Subsequent Signaling Events and Cellular Responses

Effect of Adipose Tissue-Derived Inflammatory and Proangiogenic Cytokines on Proliferative Diabetic Retinopathy

Proliferative Diabetic Retinopathy: An Overview of Vitreous Immune and Biomarkers

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