Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases

Zheng, Yongri; He, Jia‐Qiang

doi:10.31083/j.rcm2303097

Cited by 7 publications

(5 citation statements)

References 75 publications

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“…MyD88 acts as a central molecule in the inflammatory pathway ( 46 ). TLRs and interleukin-1 receptor (IL-1R) directly interact with intracellular interleukin receptor-associated kinase (IRAK) family members ( 47 , 48 ).…”

Section: Iκbζ Is Induced Via Inflammatory Signal P...mentioning

confidence: 99%

The central inflammatory regulator IκBζ: induction, regulation and physiological functions

Feng

Chen

et al. 2023

Front. Immunol.

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IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors in the NF-KB pathway, thereby affecting the progression of related diseases. In recent years, investigations into NFKBIZ have led to greater understanding of this gene. In this review, we summarize the induction of NFKBIZ and then elucidate its transcription, translation, molecular mechanism and physiological function. Finally, the roles played by NFKBIZ in psoriasis, cancer, kidney injury, autoimmune diseases and other diseases are described. NFKBIZ functions are universal and bidirectional, and therefore, this gene may exert a great influence on the regulation of inflammation and inflammation-related diseases.

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Section: Iκbζ Is Induced Via Inflammatory Signal P...mentioning

confidence: 99%

The central inflammatory regulator IκBζ: induction, regulation and physiological functions

Feng

Chen

et al. 2023

Front. Immunol.

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“…A1847 and OVCAR8 were selected for further studies, as these are representative of the HGSOC histotype. IRAK1 was originally identified as a critical mediator of IL-1β induced activation of NF-κB through the IL-1R [ 20 ]. Hence, we initially stimulated A1847 and OVCAR8 cells with IL-1β to validate functional IRAK1 signaling.…”

Section: Resultsmentioning

confidence: 99%

Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer

Standing,

Dandawate,

Gunewardena

et al. 2024

Cell Death Dis

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Advanced epithelial ovarian cancer (EOC) survival rates are dishearteningly low, with ~25% surviving beyond 5 years. Evidence suggests that cancer stem cells contribute to acquired chemoresistance and tumor recurrence. Here, we show that IRAK1 is upregulated in EOC tissues, and enhanced expression correlates with poorer overall survival. Moreover, low molecular weight hyaluronic acid, which is abundant in malignant ascites from patients with advanced EOC, induced IRAK1 phosphorylation leading to STAT3 activation and enhanced spheroid formation. Knockdown of IRAK1 impaired tumor growth in peritoneal disease models, and impaired HA-induced spheroid growth and STAT3 phosphorylation. Finally, we determined that TCS2210, a known inducer of neuronal differentiation in mesenchymal stem cells, is a selective inhibitor of IRAK1. TCS2210 significantly inhibited EOC growth in vitro and in vivo both as monotherapy, and in combination with cisplatin. Collectively, these data demonstrate IRAK1 as a druggable target for EOC.

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“…TNF-α triggers apoptosis and activates endothelium cells, hence enhancing the immunological response of fish against bacterial and viral infections ( Roca et al, 2008 ) and has a function in the immune response against bacterial and viral pathogens. IRAK , which includes IRAK3 , is responsible for facilitating the connection of various IL-1 signaling pathways and increasing the release of cytokines that promote inflammation ( Zheng and He, 2022 ). These cytokines can stop TLR1 signals from activating ( Rebl and Goldammer, 2018 ), lowering the immune response.…”

Section: Discussionmentioning

confidence: 99%

Effects on growth performance and immunity of Monopterus albus after high temperature stress

Mao,

Lv,

Huang

et al. 2024

Front. Physiol.

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To investigate the impact of the effect of high temperature stimulation on Monopterus albus larvae after a certain period of time, five experimental groups were established at different temperatures. Then, the M. albus under high temperature stress was fed at 30°C for 70 days. After that, the growth index of the M. albus was counted and analyzed. In terms of growth index, high temperature stress had significant effects on FCR, FBW, WGR, and SGR of M. albus (p < 0.05). The SR increased after being stimulated by temperature (p < 0.1). The study revealed that liver cells of M. albus were harmed by elevated temperatures of 36°C and 38°C. In the experimental group, the activities of digestive enzymes changed in the same trend, reaching the highest point in the 32°C group and then decreasing, and the AMS activity in the 38°C group was significantly different from that in the 30°C group (p < 0.05). The activities of antioxidase in liver reached the highest at 34°C, which was significantly different from those at 30°C (p < 0.05). In addition, the expression levels of TLR1, C3, TNF-α, and other genes increased in the experimental group, reaching the highest point at 34°C, and the expression level of the IL-1β gene reached the highest point at 32°C, which was significantly different from that at 30°C (p < 0.05). However, the expression level of the IRAK3 gene decreased in the experimental group and reached its lowest point at 34°C (p < 0.05). The expression level of the HSP90α gene increased with the highest temperature stimulus and reached its highest point at 38°C (p < 0.05). In the α diversity index of intestinal microorganisms in the experimental group, the observed species, Shannon, and Chao1 indexes in the 34°C group were the highest (p < 0.05), and β diversity analysis revealed that the intestinal microbial community in the experimental group was separated after high temperature stimulation. At the phylum level, the three dominant flora are Proteus, Firmicutes, and Bacteroides. Bacteroides and Macrococcus abundance increased at the genus level, but Vibrio and Aeromonas abundance decreased. To sum up, appropriate high-temperature stress can enhance the immunity and adaptability of M. albus. These results show that the high temperature stimulation of 32°C–34°C is beneficial to the industrial culture of M. albus.

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Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases

Cited by 7 publications

References 75 publications

The central inflammatory regulator IκBζ: induction, regulation and physiological functions

The central inflammatory regulator IκBζ: induction, regulation and physiological functions

Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer

Effects on growth performance and immunity of Monopterus albus after high temperature stress

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