Interleukins and cytokine biomarkers in uveitis

Balamurugan, S.; Das, Dipankar; Hasanreisoğlu, Murat; Toy, Brian C.; Akhter, Mashal; Anuradha, V K; Anthony, Eliza; Gurnani, Bharat; Kaur, Kirandeep

doi:10.4103/ijo.ijo_564_20

Cited by 30 publications

(28 citation statements)

References 109 publications

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“…An optimum balance between Th1 and Th2 cytokine production depends on the immune challenge. A variety of reports confirm that cytokine expression is augmented in the plasma, serum, cerebrospinal fluid, or aqueous humor of NIAU patients, or in patients at risk of NIU, with respect to healthy controls [ 9 , 10 , 11 , 56 , 57 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

“…The immune response in NIAU is orchestrated by a T cell-mediated autoimmune event, and chronically expanded by means of pro-inflammatory mediators, among them cytokines and chemokines [ 9 ]. A wide spectrum of pro-inflammatory cytokines and chemokines have been identified in humans and experimental NIAU models, and this knowledge has been reactivated over recent years [ 10 , 11 , 12 ], also in relation to ocular diseases [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

et al. 2021

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The purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). A prospective multicenter study was conducted in 72 participants distributed into: patients diagnosed with recurrent NIAU in the quiescence stage (uveitis group (UG); n = 36) and healthy controls (control group (CG); n = 36). Each group was randomly assigned to the oral supplementation of one pill/day (+) containing DHA-TG (n = 18) or no-pill condition (−) (n = 17) for three consecutive months. Data from demographics, risk factors, comorbidities, eye complications and therapy were recorded. Blood was collected and processed to determine pro-inflammatory biomarkers by bead-base multiplex assay. Statistical processing with multivariate statistical analysis was performed. The mean age was 50, 12 (10, 31) years. The distribution by gender was 45% males and 55% females. The mean number of uveitis episodes was 5 (2). Higher plasma expression of interleukin (IL)-6 was detected in the UG versus the CG (p = 5 × 10−5). Likewise, significantly higher plasma levels were seen for IL-1β, IL-2, INFγ (p = 10−4), and TNFα (p = 2 × 10−4) in the UG versus the CG. Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFα (p = 10−7) and IL-6 (p = 3 × 10−6) being those that most significantly changed. Signatures of circulating inflammatory mediators were obtained in the quiescent stage of recurrent NIAU patients. This 3-month follow-up strongly reinforces that a regular oral administration of DHA-TG reduces the inflammatory load and may potentially supply a prophylaxis-adjunctive mediator for patients at risk of uveitis vision loss.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

et al. 2021

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“…Various immune-regulatory cytokines (IL-6, IL-10, and IFN-γ) were detected in ocular fluid samples from patients with viral uveitis. 8 Although the CD4+ T lymphocytes drive the disease during the course of experimental uveitis, the number of CD8+ T cells is increased indicating that uveitis is the result of much more than the aberrant activation of a single cell type.…”

Section: Introductionmentioning

confidence: 99%

Clinical Profile of COVID-19 Patients Presenting with Uveitis – A Short Case Series

Iriqat¹,

Yousef²,

Ereqat³

2021

IMCRJ

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Purpose To present the clinical features of anterior, intermediate and posterior uveitis in patients with COVID-19 and to increase the awareness of the treating physicians to refer patients with COVID-19 who have eye symptoms for ophthalmic exam, in order to diagnose as early as possible and prevent vision-threatening complications. Methods Retrospective observational case reports. Results We report three cases of COVID-19 patients who developed uveitis during or after the course of their sickness with COVID-19. All patients underwent a detailed eye examination, relevant history and investigations did not prove any other cause of uveitis. Conclusion This report presents novel data on the course of subjects with uveitis during the COVID-19 pandemic. Intermediate and posterior uveitis warrant further evaluation with differential diagnosis supported by laboratory tests due to the association with systemic diseases and risk of permanent vision loss. Iridocyclitis, intermediate, and posterior uveitis treatment should be guided by ophthalmologists, particularly uveitis specialists, when possible.

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“…It currently involves the use of sophisticated immunological biomarkers,[ 5 ] molecular diagnostics, advanced imaging techniques, and manipulation of interleukins and cytokines using biological agents to get the best results for our patients. [ 6 ] Of special note are the recent advances in imaging every layer of the uveal tract including enhanced depth imaging using optical coherence tomography (EDI-OCT), swept-source OCT technology to image deeper into the choroid, fundus autofluorescence, indocyanine green angiography with confocal scanning laser imaging to get sharper images, and wide-field and ultra-wide-field imaging techniques. [ 7 ] OCT angiography (OCTA) provides retinal and choroidal vascularity indices and has the potential to revolutionize uveitis practice patterns.…”

mentioning

confidence: 99%

“…The issue begins with a beautiful account of the history and evolution of the USI, pays tribute to the pioneers of uveitis practice in India, and then moves on to many different forms of uveitis and scleritis. [ 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 ]…”

mentioning

confidence: 99%