Interleukins in diagnosis of perinatal asphyxia: A systematic review

Boskabadi, Hassan; Moradi, Ali; Zakerihamidi, Maryam

doi:10.18502/ijrm.v17i5.4598

Cited by 10 publications

(23 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inflammatory cytokines have been explored as potential biomarkers for NE; however, their predictive accuracy has varied across different studies. 12 The temporal evolution of cytokines after HI injury 35,42,63 may in part explain this variability. In a study of cytokines nested within a randomized control trial investigating erythropoietin as an adjunct agent with therapeutic hypothermia for NE, IL-10 at 16.2 h showed a modest correlation with global brain injury score on MRI; however, no correlation was observed when IL-10 was measured on day 5.…”

Section: An Association Betweenmentioning

confidence: 99%

“…Cytokine profiles in relation to NE have been studied over the past two decades, with cytokines in serum and cerebrospinal fluid variably reported to be predictive of neurodevelopmental outcome after NE. [12][13][14][15] However, studies to date have been limited by small numbers, exclusion of infants with evidence of co-infection, and a lack of long-term outcome data. In addition, studies have been largely limited to high-resource settings.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated serum IL-10 is associated with severity of neonatal encephalopathy and adverse early childhood outcomes

et al. 2021

View full text Add to dashboard Cite

Background Neonatal encephalopathy (NE) contributes substantially to child mortality and disability globally. We compared cytokine profiles in term Ugandan neonates with and without NE, with and without perinatal infection or inflammation and identified biomarkers predicting neonatal and early childhood outcomes. Methods In this exploratory biomarker study, serum IL-1α, IL-6, IL-8, IL-10, TNFα, and VEGF (<12 h) were compared between NE and non-NE infants with and without perinatal infection/inflammation. Neonatal (severity of NE, mortality) and early childhood (death or neurodevelopmental impairment to 2.5 years) outcomes were assessed. Predictors of outcomes were explored with multivariable linear and logistic regression and receiver-operating characteristic analyses. Results Cytokine assays on 159 NE and 157 non-NE infants were performed; data on early childhood outcomes were available for 150 and 129, respectively. NE infants had higher IL-10 (p < 0.001), higher IL-6 (p < 0.017), and lower VEGF (p < 0.001) levels. Moderate and severe NE was associated with higher IL-10 levels compared to non-NE infants (p < 0.001). Elevated IL-1α was associated with perinatal infection/inflammation (p = 0.013). Among NE infants, IL-10 predicted neonatal mortality (p = 0.01) and adverse early childhood outcome (adjusted OR 2.28, 95% CI 1.35–3.86, p = 0.002). Conclusions Our findings support a potential role for IL-10 as a biomarker for adverse outcomes after neonatal encephalopathy. Impact Neonatal encephalopathy is a common cause of child death and disability globally. Inflammatory cytokines are potential biomarkers of encephalopathy severity and outcome. In this Ugandan health facility-based cohort, neonatal encephalopathy was associated with elevated serum IL-10 and IL-6, and reduced VEGF at birth. Elevated serum IL-10 within 12 h after birth predicted severity of neonatal encephalopathy, neonatal mortality, and adverse early childhood developmental outcomes, independent of perinatal infection or inflammation, and provides evidence to the contribution of the inflammatory processes. Our findings support a role for IL-10 as a biomarker for adverse outcomes after neonatal encephalopathy in a sub-Saharan African cohort.

show abstract

Section: An Association Betweenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elevated serum IL-10 is associated with severity of neonatal encephalopathy and adverse early childhood outcomes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…8 Pro-inflammatory cytokines increase during acute phase after hypoxia. 9 Interleukin (IL)-6 and IL-1β are pro-inflammatory cytokines produced by astroglia, microglia, and progenitor cells oligodendrocytes in central nervous system 10 and released in early response of cells injury and inflammation. 9 The involvement of IL-6 in a clinical study including preterm newborns in the cascade of cerebral injury during perinatal period may occurred with or without infection.…”

Section: Introductionmentioning

confidence: 99%

“…9 Interleukin (IL)-6 and IL-1β are pro-inflammatory cytokines produced by astroglia, microglia, and progenitor cells oligodendrocytes in central nervous system 10 and released in early response of cells injury and inflammation. 9 The involvement of IL-6 in a clinical study including preterm newborns in the cascade of cerebral injury during perinatal period may occurred with or without infection. 11 IL-6 level in serum and brain tissues in the hypoxic-ischemic neonatal rat was significantly increased by 6 hours, reached peak by 24 hours post injury and declining to the baseline level by 7 days.…”

Section: Introductionmentioning

confidence: 99%

The Association between Asphyxia and Interleukin (IL)-6 and IL-1β Levels in Neonates

Agustina

Kosim

2021

J. Biomed. Transl. Res.

View full text Add to dashboard Cite

Background: Neonatal asphyxia is a respiratory failure during and just after birth. It can cause morbidity and mortality in neonates.Interleukin (IL)-6 and IL-1β are inflammatory cytokines produced by neuronal cells in early response to brain injury due to asphyxia. However, their role in neonatal asphyxiais remain elusive.Objective: To determine theassociation between asphyxia and serumIL-6 and IL-1β levelsin neonates.Methods: Across-sectional study was conducted on neonates diagnosed with moderate to severe asphyxia who hospitalized atthe Dr. Kariadi General Hospital Semarang Indonesia from December 2013 to May 2014. The subjects were examined for serum IL-6 and IL-1β. Blood samples were obtained from umbilical vein in the first 24 hours of life. Serum IL-6 and IL-1β levelswere measured using immunoassay. Dependent variable were IL-6 and IL-1β level. Bivariate analysis was performed using chi-square test, for the assessment of the association between dependent and independent variables. A p-value of less than 0.05 was considered statistically significant.Result: A total of 54 subjectswere enrolled in this study. No significant difference between moderate and severe asphyxia neonatesin term ofsex, birthweight,type of delivery, neonate’s mother age, gestational age, and parity. Levels of IL-6 and IL-1β levels wereincreased significantly in both moderate and severe asphyxiagroups, and the levels were significant higher in the severe asphyxia than that of in the moderate, p=0.003 and p=0.007, respectively.Conclusion:There was association between asphyxia and IL-6 and IL-1β levelsin neonates.IL-6 and IL-1β levelswere increased in neonates with moderate and severe asphyxia, with extend of increase was significant higherin the later.

show abstract

“…Результаты определения провоспалительных цитокинов у новорожденных с ГИЭ неоднозначны. В ряде масштабных исследований сообщалось о значительной взаимосвязи между сывороточными концентрациями IL-1, IL-6, IL-8, IL-18, тяжестью ГИЭ и неблагоприятными неврологическими исходами [1,4], что не всегда подтверждалось в альтернативных исследованиях.…”

unclassified

Clinical significance of pro-inflammatory interleukins in newborns with hypoxic-ischemic CNS damage

Barycheva¹,

Idrisova²,

Kuzmina³

et al. 2021

Medical news of the North Caucasus

View full text Add to dashboard Cite

Interleukins in diagnosis of perinatal asphyxia: A systematic review

Cited by 10 publications

References 32 publications

Elevated serum IL-10 is associated with severity of neonatal encephalopathy and adverse early childhood outcomes

Elevated serum IL-10 is associated with severity of neonatal encephalopathy and adverse early childhood outcomes

The Association between Asphyxia and Interleukin (IL)-6 and IL-1β Levels in Neonates

Clinical significance of pro-inflammatory interleukins in newborns with hypoxic-ischemic CNS damage

Contact Info

Product

Resources

About