Interleuskins-1 and -6 differently affect serum α1-acid glycoprotein and hepatic microsomal cytochrome P-450 levels in the rat

Chen, Y.L.; Chauvelot‐Moachon, Laurence; Giroud, Jean‐Paul

doi:10.1016/0014-2999(90)94753-k

Cited by 5 publications

(2 citation statements)

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“…In 68 of the patients in the present series, concentrations of tumour necrosis factor (TNF) were measured (mean 257; range 15-1860 pg ml-'); the levels correlated with plasma AGP (r = 0256; P < 0.05; unpublished). The administration of TNF and interleukin-1 (IL-1) to rats leads to increased serum AGP concentrations and reduced hepatic microsomal cytochrome P-450 content (Bertini et al, 1989(Bertini et al, , 1988Chen et al, 1990). In addition, plasma TNF concentrations are elevated in malaria and are particularly high in those patients with severe disease (Grau et al, 1989).…”

Section: Relationship Between Agp Concentration and Qn Bindingmentioning

confidence: 99%

Effect of Plasmodium falciparum malaria infection on the plasma concentration of alpha 1‐acid glycoprotein and the binding of quinine in Malawian children.

Mansor

Molyneux

Taylor

et al. 1991

Brit J Clinical Pharma

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3 The mean unbound QN fraction was significantly less (P < 0.00001) in patients with malaria (0.128 ± 0.037) than in controls (0.193 ± 0.051) and significantly higher (P = 0.02) in convalescence (0.153 ± 0.067) than during acute illness. 4 There were highly significant negative correlations between plasma AGP concentration and the free QN fraction in spiked plasma samples (r = -0.534, P < 0.0001, n = 93) and in clinical samples (r = -0.484, P < 0.00001, n = 225). There was a significant positive correlation between plasma concentrations of AGP and another acute phase reactant, C reactive protein (P < 0.001).

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Section: Relationship Between Agp Concentration and Qn Bindingmentioning

confidence: 99%

Effect of Plasmodium falciparum malaria infection on the plasma concentration of alpha 1‐acid glycoprotein and the binding of quinine in Malawian children.

Mansor

Molyneux

Taylor

et al. 1991

Brit J Clinical Pharma

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show abstract

“…Plasma protein binding of quinine was significantly higher and, therefore, the proportion of free drug was lower in severe and cerebral malaria (White, 1985) but this does not seem to be of sufficient severity to impair synthesis of AAG which is consistently elevated. Cytokines, notably tumour necrosis factor (TNF), may be relevant to this (Chen et al, 1990) as these mediators are variably increased in malaria (Kwiatkowski et al, 1991) and TNF has been shown to increase AAG synthesis in isolated hepatocytes. TNF does not alter the binding properties of AAG (Barnett et al, 1989).…”

Section: Patientsmentioning

confidence: 99%

Alpha 1‐acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria.

Silamut

Molunto

et al. 1991

Brit J Clinical Pharma

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Recombinant human interleukin 1? and tumor necrosis factor affect glycosylation of serum? 1-acid glycoprotein in rats

Poüs¹,

Chauvelot‐Moachon

Lecoustillier³

et al. 1992

Inflammation

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Serum concentration and glycosylation of rat alpha 1-acid glycoprotein (alpha 1-AGP) were evaluated after the in vivo administration of recombinant human interleukin-1 beta (rhIL-1 beta) and tumor necrosis factor alpha (rhTNF-alpha), alone or associated. The effect of LPS and turpentine was also studied. In all models, serum alpha 1-AGP concentrations were increased and glycosylation was altered. The alpha 1-AGP levels reached 1.8 g/liter with cytokines alone, 2.1 g/liter with cytokines associated or LPS, and 3.4 g/liter with turpentine. Analysis by concanavalin A (Con A) affinoimmunoelectrophoresis (CAIE) revealed that the relative proportion of Con A unreactive form always decreased whatever the inducing agent. On the other hand, the resulting effect on the concentrations of Con A unreactive alpha 1-AGP concentrations was an increase with cytokines alone or LPS and a decrease with cytokines associated or turpentine. These results suggest a dissociation between the alteration in the level of alpha 1-AGP synthesis and in the pattern of its glycosylation in the various inflammatory models.

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Interleuskins-1 and -6 differently affect serum α1-acid glycoprotein and hepatic microsomal cytochrome P-450 levels in the rat

Cited by 5 publications

References 0 publications

Effect of Plasmodium falciparum malaria infection on the plasma concentration of alpha 1‐acid glycoprotein and the binding of quinine in Malawian children.

Effect of Plasmodium falciparum malaria infection on the plasma concentration of alpha 1‐acid glycoprotein and the binding of quinine in Malawian children.

Alpha 1‐acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria.

Recombinant human interleukin 1? and tumor necrosis factor affect glycosylation of serum? 1-acid glycoprotein in rats

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