Interlimb neural interactions in the corticospinal pathways

Tazoe, Toshiki; Komiyama, Tomoyoshi

doi:10.7600/jpfsm.3.181

Cited by 11 publications

(14 citation statements)

References 105 publications

(231 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, before the relaxation (i.e., during contraction) of both the TA and SOL, we observed significant increases in MEP for both the ECR and FCR (Figure 3 ). This corresponds well with the results in previous studies which indicate that the facilitatory effect of the cortical mechanism on one limb during static contraction of other limbs displays a non-topographic characteristic (Tazoe et al, 2007 ; Chiou et al, 2013 ; Tazoe and Komiyama, 2014 ). The fact that the decrease in corticospinal excitability was observed in both ECR and FCR during TA relaxation indicated that the effect of foot relaxation spread to the forearm muscles, regardless of whether they were extensors or flexors (Figure 3 ).…”

Section: Discussionsupporting

confidence: 92%

Muscle Relaxation of the Foot Reduces Corticospinal Excitability of Hand Muscles and Enhances Intracortical Inhibition

Kato

Muraoka

Mizuguchi

et al. 2016

Front. Hum. Neurosci.

View full text Add to dashboard Cite

The object of this study was to clarify the effects of foot muscle relaxation on activity in the primary motor cortex (M1) of the hand area. Subjects were asked to volitionally relax the right foot from sustained contraction of either the dorsiflexor (tibialis anterior; TA relaxation) or plantarflexor (soleus; SOL relaxation) in response to an auditory stimulus. Single- and paired-pulse transcranial magnetic stimulation (TMS) was delivered to the hand area of the left M1 at different time intervals before and after the onset of TA or SOL relaxation. Motor evoked potentials (MEPs) were recorded from the right extensor carpi radialis (ECR) and flexor carpi radialis (FCR). MEP amplitudes of ECR and FCR caused by single-pulse TMS temporarily decreased after TA and SOL relaxation onset, respectively, as compared with those of the resting control. Furthermore, short-interval intracortical inhibition (SICI) of ECR evaluated with paired-pulse TMS temporarily increased after TA relaxation onset. Our findings indicate that muscle relaxation of the dorsiflexor reduced corticospinal excitability of the ipsilateral hand muscles. This is most likely caused by an increase in intracortical inhibition.

show abstract

Section: Discussionsupporting

confidence: 92%

Muscle Relaxation of the Foot Reduces Corticospinal Excitability of Hand Muscles and Enhances Intracortical Inhibition

Kato

Muraoka

Mizuguchi

et al. 2016

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Overall, these results imply that the remote effect results from both cortical and subcortical mechanisms; however, the relative contribution of each mechanism is not known (for a review, see ref. 26). …”

Section: Discussionmentioning

confidence: 99%

“…have reported that voluntary isometric knee extension facilitated wrist flexor MEP with linear relationship to knee extension force, and it remained unchanged even when knee extension force decreased due to central and peripheral muscle fatigue. It has been proposed that lack of reduction in MEP facilitation during the presence of fatigue may imply that the M1 is the source of neural generation of MEP facilitation in a remote segment26. Moreover, Tazoe et al 13.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, it has been proposed that motor training of an unaffected (or less affected) limb might be advantageous for improving motor recovery of a limb after a stroke or spinal cord injuries26. Moreover, boosting corticospinal excitability through contraction of muscles in remote parts of the body could be beneficial since in patients with central nervous system diseases, it may be challenging or even impossible to elicit reproducible MEPs in target muscles4.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Preparation and execution of teeth clenching and foot muscle contraction influence on corticospinal hand-muscle excitability

Komeilipoor

Ilmoniemi

Tiippana

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Contraction of a muscle modulates not only the corticospinal excitability (CSE) of the contracting muscle but also that of different muscles. We investigated to what extent the CSE of a hand muscle is modulated during preparation and execution of teeth clenching and ipsilateral foot dorsiflexion either separately or in combination. Hand-muscle CSE was estimated based on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) and recorded from the first dorsal interosseous (FDI) muscle. We found higher excitability during both preparation and execution of all the motor tasks than during mere observation of a fixation cross. As expected, the excitability was greater during the execution phase than the preparation one. Furthermore, both execution and preparation of combined motor tasks led to higher excitability than individual tasks. These results extend our current understanding of the neural interactions underlying simultaneous contraction of muscles in different body parts.

show abstract

“…Corticospinal remote facilitation has been studied extensively between upper-and lowerlimb muscles (Kawakita et al, 1991;Pereon et al, 1995;Tazoe and Komiyama, 2014) and this phenomenon is known as remote effect or crossed facilitation (Tazoe and Komiyama, 2014).…”

Section: Introductionmentioning

confidence: 99%

Task- and Intensity-Dependent Modulation of Arm-Trunk Neural Interactions in the Corticospinal Pathway in Humans

Sasaki

Kaneko

Masugi

et al. 2021

eNeuro

View full text Add to dashboard Cite

Most human movements require coordinated activation of multiple muscles. Although many studies reported associations between arm, leg, and trunk muscles during functional tasks, their neural interaction mechanisms still remain unclear. Therefore, the aim of our study was to investigate arm-trunk or arm-leg neural interactions in the corticospinal tract during different arm muscle contractions. Specifically, we examined corticospinal excitability of the erector spinae (ES; trunk extensor), rectus abdominis (RA; trunk flexor), and tibialis anterior (TA; leg) muscles while participants exerted: (1) wrist flexion; and (2) wrist extension isometric contraction at various contraction intensity levels ranging from rest to 50% of maximal voluntary contraction (MVC) effort. Corticospinal excitability was assessed using motor evoked potentials (MEPs) elicited through motor cortex transcranial magnetic stimulation. Results showed that ES MEPs were facilitated even at low contractions (>5% MVC) during wrist flexion and extension, while stronger contractions (>25% MVC) were required to facilitate RA MEPs. The extent of facilitation of ES MEPs depended on contraction intensity of wrist extension, but not flexion.Moreover, TA MEPs were facilitated at low contractions (>5% MVC) during wrist flexion and extension, but contraction intensity dependence was only shown during stronger wrist extension contractions (>25% MVC). In conclusion, trunk extensor corticospinal excitability seems to depend on the task and the intensity of arm contraction, while this is not true for trunk flexor and leg muscles. Our study therefore demonstrated task-and intensity-dependent neural interactions of arm-trunk connections, which may underlie anatomical and/or functional substrates of these muscle pairs. 4 Significance StatementAlthough it is known that most human movements require coordinated activation of multiple muscles, understanding of how they are controlled in the central nervous system still lacks. Our study investigated the characteristics of neural interactions of arm-trunk and arm-leg muscles in the corticospinal tract of human participants using motor evoked potentials elicited by transcranial magnetic stimulation. We showed that arm muscle contractions can facilitate corticospinal excitability of the trunk and leg muscles. Specifically, arm-trunk neural interactions depended on the task and intensity of arm movements. Our findings therefore suggest that corticospinal neurons have complex output patterns to distinct muscles in different body segments, which may depend on the anatomical and/or functional relationship of these muscle pairs.

show abstract

Interlimb neural interactions in the corticospinal pathways

Cited by 11 publications

References 105 publications

Muscle Relaxation of the Foot Reduces Corticospinal Excitability of Hand Muscles and Enhances Intracortical Inhibition

Muscle Relaxation of the Foot Reduces Corticospinal Excitability of Hand Muscles and Enhances Intracortical Inhibition

Preparation and execution of teeth clenching and foot muscle contraction influence on corticospinal hand-muscle excitability

Task- and Intensity-Dependent Modulation of Arm-Trunk Neural Interactions in the Corticospinal Pathway in Humans

Contact Info

Product

Resources

About