Interlink between stress and periodontal disease

Reddy, Surakanti Jayaprada; Kaul, Subhash; Prasad, Madu Ghanashyam; Agnihotri, Jaya; Amudha, D.; Vinayak, Rohin

doi:10.3126/hren.v10i2.6579

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…The behavioral mechanism emphasizes that people suffering from stress and depression may increase smoking or drinking more frequently, consume an unhealthy diet and neglect their oral hygiene. This leads to increased oral biofilm burden and decreased resistance of the periodontium to inflammatory breakdown [75,76]. Stress management through counseling may bring significant change in periodontal status of these patients.…”

Section: Chronic Periodontal Diseasementioning

confidence: 99%

Crosstalk between Mind and Oral Cavity: An Insight into Pathogenesis, Classification, Presentation and Management of Oral Psychosomatic Disorders

Jain

Mehendiratta²,

Kardam³

et al. 2016

INDJ

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In general, the conviction is that psychological factors are important in the development of all disease. Epidemiological surveys have revealed that there are different ways in which emotional stressful stimuli can act on oral mucosal target sites. Whether their role is in initiation, progression, aggravation or exacerbation of disease or in predisposition or reaction to a disease is still not clear. Based on available evidences, a need for the understanding of oral psychosomatic disturbances is felt. This review summarizes the underlying pathophysiology of bodily changes brought about by stress related psychosomatic mechanism and their role in further development of structural changes seen in association with oral cavity. An effort has also been made to realize the significant Review Article role of reassurance and counselling procedures in overall management of patients with oral psychosomatic disorders.

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Section: Chronic Periodontal Diseasementioning

confidence: 99%

Crosstalk between Mind and Oral Cavity: An Insight into Pathogenesis, Classification, Presentation and Management of Oral Psychosomatic Disorders

Jain

Mehendiratta²,

Kardam³

et al. 2016

INDJ

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“…Many caries risk factors such as decreased salivary flow rate (Matos- Gomes, Katsurayama et al 2010), poor oral hygiene (Reddy, Kaul et al 2012), and calorically dense food intake together with high sugar intake are negatively influenced by stress response (Adam andEpel 2007, Michels, Sioen et al 2012).…”

Section: Stress Response and Dental Cariesmentioning

confidence: 99%

Children with orofacial clefts : dental caries and health-related quality of life

Sundell¹

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Chronic stress accelerates ligature-induced periodontitis by suppressing glucocorticoid receptor-α signaling

Wang

et al. 2016

Exp Mol Med

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Periodontitis is a common chronic inflammatory disease. Recent studies have shown that chronic stress (CS) might modulate periodontal disease, but there are few models of CS-induced periodontitis, and the underlying mechanisms are unclear. The present study established a rat model of periodontitis associated with CS induced by nylon thread ligatures. The severity of periodontitis was evaluated in this model by radiographic and pathological examination. The inflammatory reaction indicated by the elevated serum levels of interleukin (IL)-1β, IL-6 and IL-8 was assessed by enzyme-linked immunosorbent assay. Toll-like receptor-4 (TLR4) and glucocorticoid receptor-α (GR-α) expressions were detected by reverse transcriptase-PCR and western blotting. Open-field tests and serum corticosterone were used to evaluate CS. The results showed that CS induced behavioral changes and increased corticosterone levels of the animals with periodontitis. CS stimulation markedly increased alveolar bone loss, periodontal pocket depth and the number of plaques. It also enhanced the inflammatory reaction. These results suggest that CS accelerated the ligature-induced pathological changes associated with periodontitis. Further analysis of the mechanisms involved showed that GR-α expression was significantly downregulated in periodontal tissues of the animals undergoing CS. Blocking GR-α signaling in lipopolysaccharide and corticosteroid-treated human periodontal ligament fibroblast cells in vitro significantly upregulated the expression of p-Akt (protein kinase B) and TLR4, promoted nuclear factor-κB activity and increased levels of IL-1β, IL-6 and IL-8. This research suggests that CS might accelerate the pathological progression of periodontitis by a GR-α signaling-mediated inflammatory response and that this may be a potential therapeutic target for the treatment of periodontal disease, particularly in patients with CS.

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Interlink between stress and periodontal disease

Cited by 3 publications

References 38 publications

Crosstalk between Mind and Oral Cavity: An Insight into Pathogenesis, Classification, Presentation and Management of Oral Psychosomatic Disorders

Crosstalk between Mind and Oral Cavity: An Insight into Pathogenesis, Classification, Presentation and Management of Oral Psychosomatic Disorders

Children with orofacial clefts : dental caries and health-related quality of life

Chronic stress accelerates ligature-induced periodontitis by suppressing glucocorticoid receptor-α signaling

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