This entry turns to comics as a test case for intermedia theory. It suggests a pragmatic understanding of comics as a medium that conventionally narrates through the combination of images and words as they unfold in sequences of panels and are determined by the materiality of the page as well as different publication formats (such as comic strip, comic book, graphic novel). The entry uses Bill Sienkiewicz's comic book adaptation of Herman Melville's novel Moby-Dick to test the explanatory potential of some of the central classifications developed by intermedia theory (media combination, media transposition, intermediality, intramediality, transmediality), endorsing a notion of intermediality that is broad enough to incorporate theories and methodologies from the field of comics studies.