Intermediary metabolism in parasitic helminths

McManus, Donald P.

doi:10.1016/0020-7519(87)90029-4

Cited by 8 publications

(5 citation statements)

References 125 publications

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“…Nevertheless, a high pO 2 at the parasite’s site does not necessarily imply that aerobic metabolism is present. An example of this is observed in S. mansoni , whose adult form lodges in the portal vein and whose metabolism has been reported to be preferably anaerobic, although this is not exclusive [ 74 , 75 ]. In contrast, the exceptionally high affinity for oxygen presented by the Hb of the fluke Ophisthorchis viverrini allows it to live in a practically anaerobic environment, such as the bile ducts [ 76 ].…”

Section: Adaptations Of Parasitic Flatworms To Changes In Oxygen Tensionmentioning

confidence: 99%

Evolutionary Adaptations of Parasitic Flatworms to Different Oxygen Tensions

2022

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During the evolution of the Earth, the increase in the atmospheric concentration of oxygen gave rise to the development of organisms with aerobic metabolism, which utilized this molecule as the ultimate electron acceptor, whereas other organisms maintained an anaerobic metabolism. Platyhelminthes exhibit both aerobic and anaerobic metabolism depending on the availability of oxygen in their environment and/or due to differential oxygen tensions during certain stages of their life cycle. As these organisms do not have a circulatory system, gas exchange occurs by the passive diffusion through their body wall. Consequently, the flatworms developed several adaptations related to the oxygen gradient that is established between the aerobic tegument and the cellular parenchyma that is mostly anaerobic. Because of the aerobic metabolism, hydrogen peroxide (H2O2) is produced in abundance. Catalase usually scavenges H2O2 in mammals; however, this enzyme is absent in parasitic platyhelminths. Thus, the architecture of the antioxidant systems is different, depending primarily on the superoxide dismutase, glutathione peroxidase, and peroxiredoxin enzymes represented mainly in the tegument. Here, we discuss the adaptations that parasitic flatworms have developed to be able to transit from the different metabolic conditions to those they are exposed to during their life cycle.

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Section: Adaptations Of Parasitic Flatworms To Changes In Oxygen Tensionmentioning

confidence: 99%

Evolutionary Adaptations of Parasitic Flatworms to Different Oxygen Tensions

2022

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“…cervi to interconvert amino acids. Transamination between α-ketoglutarate and aspartate or alanine could be detected and glutamate dehydrogenase has been partially purified and characterized (McManus, 1987). Other enzymes present in crude extracts of adult S .…”

Section: Amino Acid and Protein Metabolismmentioning

confidence: 99%

“…Very little is known about the ability of adult S. cervi to interconvert amino acids. Transamination between a-ketoglutarate and aspartate or alanine could be detected and glutamate dehydrogenase has been partially purified and characterized (McManus, 1987). Other enzymes present in crude extracts of adult S. cervi were L-alanine dehydrogenase, L-threonine dehydratase, L-ornithine transcarbamoylase and arginase.…”

Section: Amino Acid and Protein Metabolismmentioning

confidence: 99%

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Biochemical composition and metabolic pathways of filarial worms Setaria cervi: search for new antifilarial agents

Ahmad

Srivastava

2007

J. Helminthol.

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The main problem regarding the chemotherapy of filariasis is that no safe and effective drug is available yet to combat the adult human filarial worms. Setaria cervi, the causal organism of setariasis and lumbar paralysis in cattle, is routinely employed as a model organism for conducting biochemical and enzymatic studies on filarial parasites. In view of the practical difficulties in procuring human strains of Wuchereria bancrofti and Brugia malayi for drug screening, the bovine filarial parasite S. cervi, resembling the human species in having microfilarial periodicity and chemotherapeutic response to known antifilarial agents, is widely used as a model in such studies. For a rational approach to antifilarial chemotherapy, knowledge of the biochemical composition and metabolic pathways of this helminth parasite may be of paramount importance, so that more potent antifilarial agents based on specific drug targets can be identified in drug discovery programmes. The present review provides an update on the biochemistry of the important metabolic pathways functioning within this potentially important bovine parasite, that have so far been studied, and on those that need to be investigated further so as to identify novel drug targets that can be exploited for designing new antifilarial drugs.

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“…Mais recentemente, alguns trabalhos passaram a exibir asserções sobre os mecanismos evolutivos dessas modificações tão drásticas no escopo fisiológico, mas tão discretas sob o ponto de vista mecanístico do metabolismo. Ainda que tímidas em muitos casos, essas asserções são geralmente restritas a alguns grupos de seres vivos para os quais havia mais dados disponíveis na literatura (Prestwich e Ing, 1982;McManus, 1987;Bradley, 2000;Andjus et al, 2000;Jackson e Nichonson, 2002).…”

Section: Não Há Possibilidade De Negar O Triunfo Dessa Abordagem Reduunclassified

Hipótese evolutiva sobre a assimilição de compostos nitrogenados por metazoários: a limitação α-aminoácidos

Montagna¹

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Intermediary metabolism in parasitic helminths

Cited by 8 publications

References 125 publications

Evolutionary Adaptations of Parasitic Flatworms to Different Oxygen Tensions

Evolutionary Adaptations of Parasitic Flatworms to Different Oxygen Tensions

Biochemical composition and metabolic pathways of filarial worms Setaria cervi: search for new antifilarial agents

Hipótese evolutiva sobre a assimilição de compostos nitrogenados por metazoários: a limitação α-aminoácidos

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