Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics

Bodegraven, Emma J. van; Etienne-Manneville, Sandrine

doi:10.3390/cells10081905

Cited by 34 publications

(33 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Migration in turn is reliant on the ability of cells to attach to ECM proteins and to navigate through pores in the ECM, which, depending on their size, may require cell deformation. The deformability of a cell and its ability to return to its original shape are affected by the viscoelastic properties of cells and their constituents ( Moeendarbary et al, 2013 ; van Bodegraven and Etienne-Manneville, 2021 ). VIFs exhibit distinct viscoelastic properties that are not typically exhibited by other filamentous biopolymers such as actin filaments ( Shah et al, 1998 ).…”

Section: Viscoelastic Properties Of Vimentin Enhance Cell Resistance ...mentioning

confidence: 99%

“…Cell-specific levels of vimentin expression, PTMs, and direct and indirect interactions with other cytoskeletal components, control the mechanical properties of cells during migration and ECM remodeling. It appears that the extraordinarily broad array of PTMs of vimentin and its structure in response to extracellular and intracellular mechanical signals are crucial for cell and tissue integrity ( Costigliola et al, 2017 ; Messica et al, 2017 ; van Bodegraven and Etienne-Manneville, 2021 ). Expression of VIF may thus control the mechanical properties of the cells and modify their ability to remodel collagen by its incorporation as an adaptor protein in the β1 integrin adhesive machinery ( Terriac et al, 2017 ; Ostrowska-Podhorodecka et al, 2021 ).…”

Section: Conclusion and Future Perspectives: A Role For Vimentin As A...mentioning

confidence: 99%

See 1 more Smart Citation

Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling

Ostrowska-Podhorodecka

Ding

Norouzi

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Vimentin expression contributes to cellular mechanoprotection and is a widely recognized marker of fibroblasts and of epithelial-mesenchymal transition. But it is not understood how vimentin affects signaling that controls cell migration and extracellular matrix (ECM) remodeling. Recent data indicate that vimentin controls collagen deposition and ECM structure by regulating contractile force application to the ECM and through post-transcriptional regulation of ECM related genes. Binding of cells to the ECM promotes the association of vimentin with cytoplasmic domains of adhesion receptors such as integrins. After initial adhesion, cell-generated, myosin-dependent forces and signals that impact vimentin structure can affect cell migration. Post-translational modifications of vimentin determine its adaptor functions, including binding to cell adhesion proteins like paxillin and talin. Accordingly, vimentin regulates the growth, maturation and adhesive strength of integrin-dependent adhesions, which enables cells to tune their attachment to collagen, regulate the formation of cell extensions and control cell migration through connective tissues. Thus, vimentin tunes signaling cascades that regulate cell migration and ECM remodeling. Here we consider how specific properties of vimentin serve to control cell attachment to the underlying ECM and to regulate mesenchymal cell migration and remodeling of the ECM by resident fibroblasts.

show abstract

Section: Viscoelastic Properties Of Vimentin Enhance Cell Resistance ...mentioning

confidence: 99%

Section: Conclusion and Future Perspectives: A Role For Vimentin As A...mentioning

confidence: 99%

Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling

Ostrowska-Podhorodecka

Ding

Norouzi

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Cell stress signaling is a central function of the ER in the regulation of cellular metabolism in homeostatic and disease states ( 24 ). Likewise, intermediate filaments provide cells and tissues with resistance to mechanical and chemical stresses, particularly in the heart, skin, and liver ( 20, 25, 26 ). Interestingly, ER stress has been implicated in epidermal fragility disorders caused by keratin or desmosome dysfunction ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Architecture and dynamics of a novel desmosome-endoplasmic reticulum organelle

Bharathan

Giang

Aaron

et al. 2022

Preprint

View full text Add to dashboard Cite

The endoplasmic reticulum (ER) forms a dynamic network that contacts other cellular membranes to regulate stress responses, calcium signaling, and lipid transfer. Using high-resolution volume electron microscopy, we find that the ER forms a previously unknown association with keratin intermediate filaments and desmosomal cell-cell junctions. Peripheral ER assembles into mirror image-like arrangements at desmosomes and exhibits nanometer proximity to keratin filaments and the desmosome cytoplasmic plaque. ER tubules exhibit stable associations with desmosomes, and perturbation of desmosomes or keratin filaments alters ER organization and mobility. These findings indicate that desmosomes and the keratin cytoskeleton pattern the distribution of the ER network. Overall, this study reveals a previously unknown subcellular architecture defined by the structural integration of ER tubules with an epithelial intercellular junction.

show abstract

“…The cytoskeleton is a complex intermingled meshwork of three major classes of filamentous macromolecules: MFs, MTs and IFs. These three cytoskeletal macromolecules mainly differ in their mechanical stiffness, the dynamics of their assembly, their polarity, and the type of associated molecular motors [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Cell-intrinsic Mechanisms Of Cell Shape Controlmentioning

confidence: 99%

Cell Architecture-Dependent Constraints: Critical Safeguards to Carcinogenesis

Khalil

Eon

Janody

2022

IJMS

View full text Add to dashboard Cite

Animal cells display great diversity in their shape. These morphological characteristics result from crosstalk between the plasma membrane and the force-generating capacities of the cytoskeleton macromolecules. Changes in cell shape are not merely byproducts of cell fate determinants, they also actively drive cell fate decisions, including proliferation and differentiation. Global and local changes in cell shape alter the transcriptional program by a multitude of mechanisms, including the regulation of physical links between the plasma membrane and the nuclear envelope and the mechanical modulation of cation channels and signalling molecules. It is therefore not surprising that anomalies in cell shape contribute to several diseases, including cancer. In this review, we discuss the possibility that the constraints imposed by cell shape determine the behaviour of normal and pro-tumour cells by organizing the whole interconnected regulatory network. In turn, cell behaviour might stabilize cells into discrete shapes. However, to progress towards a fully transformed phenotype and to acquire plasticity properties, pro-tumour cells might need to escape these cell shape restrictions. Thus, robust controls of the cell shape machinery may represent a critical safeguard against carcinogenesis.

show abstract

Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics

Cited by 34 publications

References 117 publications

Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling

Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling

Architecture and dynamics of a novel desmosome-endoplasmic reticulum organelle

Cell Architecture-Dependent Constraints: Critical Safeguards to Carcinogenesis

Contact Info

Product

Resources

About