Intermediate hair follicles: a new more clinically relevant model for hair growth investigations

Miranda, Benjamin H.; Tobin, Desmond J.; Sharpe, David T.; Randall, Valerie A.

doi:10.1111/j.1365-2133.2010.09867.x

Cited by 32 publications

(26 citation statements)

References 40 publications

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“…This is maintained in the context of progressive hair loss in which the size of the follicle and hair it produces is reduced in successive hair cycles until a miniaturized vellus hair follicle results ( Fig. 2) (Miranda et al 2010). A similar correlation is observed in injury-induced whisker regeneration experiments in the rat (Ibrahim and Wright 1982).…”

Section: Dp Cell Number Correlates With Hair Size and Typesupporting

confidence: 57%

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

Morgan

2014

Cold Spring Harbor Perspectives in Medicine

182

151

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The dermal papilla (DP) of the hair follicle is both a chemical and physical niche for epithelial progenitor cells that regenerate the cycling portion of the hair follicle and generate the hair shaft. Here, we review experiments that revealed the importance of the DP in regulating the characteristics of the hair shaft and frequency of hair follicle regeneration. More recent work showed that the size of this niche is dynamic and actively regulated and reduction in DP cell number per follicle is sufficient to cause hair thinning and loss. The formation of the DP during follicle neogenesis provides a context to contemplate the mechanisms that maintain DP size and the potential to exploit these processes for hair preservation or restoration.

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Section: Dp Cell Number Correlates With Hair Size and Typesupporting

confidence: 57%

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

Morgan

2014

Cold Spring Harbor Perspectives in Medicine

182

151

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“…Balding follicles exhibit shrinkage and rounding of the dermal papilla (Miranda et al, 2010), suggesting restricted cell migration. Here we show BDPC have slower migratory velocity than ODPC under both oxygen conditions.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

Upton

Hannen

Bahta

et al. 2015

Journal of Investigative Dermatology

160

157

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Dermal papilla cells (DPCs) taken from male androgenetic alopecia (AGA) patients undergo premature senescence in vitro in association with the expression of p16(INK4a), suggesting that DPCs from balding scalp are more sensitive to environmental stress than nonbalding cells. As one of the major triggers of senescence in vitro stems from the cell "culture shock" owing to oxidative stress, we have further investigated the effects of oxidative stress on balding and occipital scalp DPCs. Patient-matched DPCs from balding and occipital scalp were cultured at atmospheric (21%) or physiologically normal (2%) O2. At 21% O2, DPCs showed flattened morphology and a significant reduction in mobility, population doubling, increased levels of reactive oxygen species and senescence-associated β-Gal activity, and increased expression of p16(INK4a) and pRB. Balding DPCs secreted higher levels of the negative hair growth regulators transforming growth factor beta 1 and 2 in response to H2O2 but not cell culture-associated oxidative stress. Balding DPCs had higher levels of catalase and total glutathione but appear to be less able to handle oxidative stress compared with occipital DPCs. These in vitro findings suggest that there may be a role for oxidative stress in the pathogenesis of AGA both in relation to cell senescence and migration but also secretion of known hair follicle inhibitory factors.

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“…Intermediate follicles34, appeared thinner and less pigmented than terminal follicles and were obtained from 3 mm punch biopsies taken from the balding scalp of male patients undergoing hair transplantation surgery. Ethical permission and informed consent were obtained preoperatively.…”

Section: Methodsmentioning

confidence: 99%

Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth

Dong

Hao

Xia

et al. 2014

Sci Rep

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Hair loss (alopecia) is a common problem for people. The dermal papilla is the key signaling center that regulates hair growth and it engage in crosstalk with the microenvironment, including Wnt signaling and stem cells. In this study, we explored the effects of bone marrow mesenchymal stem cell overexpression of Wnt1a on mouse hair follicle regeneration. Wnt-CM accelerated hair follicle progression from telogen to anagen and enhanced the ALP expression in the DP area. Moreover, the hair induction-related genes were upregulated, as demonstrated by qRT-PCR. Wnt-CM treatment restored and increased DP cell expression of genes downregulated by dihydrotestosterone treatment, as demonstrated by qRT-PCR assays. Our study reveals that BM-MSC-generated Wnt1a promotes the DP's ability to induce hair cycling and regeneration.

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Intermediate hair follicles: a new more clinically relevant model for hair growth investigations

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Cited by 32 publications

References 40 publications

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth

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