Intermediate monocytes exhibit higher levels of TLR2, TLR4 and CD64 early after congenital heart surgery

Merbecks, Moritz B.; Ziesenitz, Victoria C.; Rubner, Tobias; Meier, Noëmi; Klein, Berthold; Rauch, Helmut; Saur, P.; Ritz, Nicole; Loukanov, Tsvetomir; Schmitt, Steffen; Gorenflo, Matthias

doi:10.1016/j.cyto.2020.155153

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…Merbecks и соавт. продемонстрировали, что у детей, перенесших операцию на сердце, наблюдалось увеличение экспрессии TLR2 на моноцитах в первые и вторые сутки после вмешательства [10]. В настоящем исследовании именно ген TLR2 имел наибольший предсказательный потенциал в отношении риска послеоперационных осложнений.…”

Section: Discussionunclassified

Role of toll-like receptors in complications of cardiac surgery for congenital heart defects in children

Цепокина¹,

Rumyantseva²,

Шмулевич³

et al. 2021

PKiK

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Background. Cardiac surgery in combination with hypothermia, ischaemia and reperfusion leads to an inflammatory response causing postoperative complications. Toll-like receptors are signalling molecules through which some functions of innate immunity can be activated, and polymorphic variants in the TLR-family genes can be predictors of complications after cardiac surgery. Aim. To study the associations of TLR-family genes with infectious and non-infectious complications of cardiac surgery for congenital heart defects. Methods. The study included 89 children (44 girls and 45 boys) with congenital heart defects who underwent cardiac surgery. Complications occurred in 47 children 47 days after cardiac surgery. There were no complications in 42 children. Genotyping was performed by real-time PCR using TaqMan probes. Results. A two-locus model of gene-gene interaction between TLR1 rs5743551 and TLR2 rs3804099 was the best fit, accounting for 4.01% of phenotypic entropy. The TLR2 gene polymorphic variant rs5743708 had the highest predictive potential (2.59%). Conclusion. The development of postoperative complications of cardiac surgical treatment for congenital heart defects can be due to the synergistic effect of the polymorphic variants rs5743551 in the TLR1 gene and rs3804099 in the TLR2 gene. This effect occurs through the features of TLR1 and TLR2 transcription, the subsequent expression of receptors on cells and signalling which activates the synthesis of proinflammatory cytokines and chemokines.Received 25 February 2021. Revised 11 May 2021. Accepted 12 May 2021.Funding: The work is supported by the complex program of fundamental research of the Siberian Branch of the Russian Academy of Sciences (No. 0554-2019-0002).Conflict of interest: The authors declare no conflicts of interests.Contribution of the authors Conception and study design: A.V. Shabaldin, A.V. Ponasenko, A.V. Tsepokina Data collection and analysis: A.A. Anikeenko, A.V. Tsepokina, S.A. Shmulevich Statistical analysis: A.V. Shabaldin, A.V. Tsepokina Drafting the article: A.V. Shabaldin, A.V. Tsepokina, A.V. Ponasenko Critical revision of the article: A.V. Tsepokina Final approval of the version to be published: A.V. Tsepokina, A.A. Anikeenko, S.A. Shmulevich, A.V. Ponasenko, A.V. Shabaldin

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Section: Discussionunclassified

Role of toll-like receptors in complications of cardiac surgery for congenital heart defects in children

Цепокина¹,

Rumyantseva²,

Шмулевич³

et al. 2021

PKiK

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“…CPB is known to induce inflammation, both at the intestinal and systemic levels [ 142 ]. In the early stages following CHD operation, intermediate monocytes exhibit increased levels of CD64, TLR2, and TLR4, which may be associated with impaired postoperative recovery and organ dysfunction [ 143 ]. The classical perioperative factor NLR serves as a reflection of systemic inflammation and has been correlated with the composition of the gut microbiome [ 73 , 74 ].…”

Section: Gut Microbiome and Pediatric Cardiovascular Surgerymentioning

confidence: 99%

From heart to gut: Exploring the gut microbiome in congenital heart disease

Liu,

Huang,

et al. 2023

iMeta

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Congenital heart disease (CHD) is a prevalent birth defect and a significant contributor to childhood mortality. The major characteristics of CHD include cardiovascular malformations and hemodynamical disorders. However, the impact of CHD extends beyond the circulatory system. Evidence has identified dysbiosis of the gut microbiome in patients with CHD. Chronic hypoxia and inflammation associated with CHD affect the gut microbiome, leading to alterations in its number, abundance, and composition. The gut microbiome, aside from providing essential nutrients, engages in direct interactions with the host immune system and indirect interactions via metabolites. The abnormal gut microbiome or its products can translocate into the bloodstream through an impaired gut barrier, leading to an inflammatory state. Metabolites of the gut microbiome, such as short‐chain fatty acids and trimethylamine N‐oxide, also play important roles in the development, treatment, and prognosis of CHD. This review discusses the role of the gut microbiome in immunity, gut barrier, neurodevelopment, and perioperative period in CHD. By fostering a better understanding of the cross‐talk between CHD and the gut microbiome, this review aims to contribute to improve clinical management and outcomes for CHD patients.

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Role of Monocyte/Macrophages in the Pathogenesis of NeuroHIV

Ajasin,

Eugenin

2024

Results and Problems in Cell Differentiation

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Intermediate monocytes exhibit higher levels of TLR2, TLR4 and CD64 early after congenital heart surgery

Cited by 6 publications

References 45 publications

Role of toll-like receptors in complications of cardiac surgery for congenital heart defects in children

Role of toll-like receptors in complications of cardiac surgery for congenital heart defects in children

From heart to gut: Exploring the gut microbiome in congenital heart disease

Role of Monocyte/Macrophages in the Pathogenesis of NeuroHIV

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