Intermediate Phenotypes in Genetic Studies of Schizophrenia

Egan, Michael; Leboyer, Marion; Weinberger, D.R.

doi:10.1002/9780470987353.ch15

Cited by 4 publications

(2 citation statements)

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“…To minimize imprecision introduced by categorical diagnosis, new strategies have been developed aimed at identifying more basic neurobiological traits related to genetic risk. These are intermediate phenotypes or so‐called endophenotypes 8 . Examples include eye tracking dysfunction, clinical phenotypes (e.g.…”

Section: Aetiologymentioning

confidence: 99%

Recognition and optimal management of schizophrenia and related psychoses

Singh

2005

Internal Medicine Journal

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Schizophrenia continues to remain one of the major unsolved conditions of our time, contributing significantly to causes of disability worldwide. Advances in neuroimaging have demonstrated that schizophrenia appears to be primarily a neurodevelopmental disorder. The dopamine theory of schizophrenia continues to hold sway but interest is growing in the role of other neurotransmitters. Genetic linkage studies continue to suggest that specific chromosomes have a role in the aetiology of the condition but the findings are, as yet, inconsistent. A new generation of drug therapies and reforms of the mental health system have meant that it is now possible to treat the majority of those with this condition in the community albeit, in some instances, against their will. The medical complications of both the disorder, the lifestyle changes resulting from the disorder and the new and older medications have come to prominence in recent years. The development of guidelines for treatment has the potential to reduce the variability in clinical practice that currently exists in the management of the condition. (Intern Med J 2005; 35: 413-418)

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Section: Aetiologymentioning

confidence: 99%

Recognition and optimal management of schizophrenia and related psychoses

Singh

2005

Internal Medicine Journal

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“…Les chercheurs dans ce domaine peinent à identifier un trait suffisamment bien défini et mesurable qui manifeste ne serait-ce qu'une faible association avec la catégorie de diagnostic (mal définie) de la schizophrénie. Des exemples de tels traits sont : des déficits dans « la recherche visuelle » et des anormalités dans les potentiels évoqués à P300 et P50, associées avec le traitement sensoriel des sons (nouveauté, filtrage) Voir Egan et al, 2003, pour une discussion de tels « phénotypes intermédiaires ». pouvoir prédictif ou pour la compréhension de la condition de la personne 14 .…”

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Étapes vers un monde sans schizophrénie

Poland

2006

philoso

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Cet article présente des arguments selon lesquels le concept de schizophrénie est un stéréotype préjudiciable qu’il vaudrait mieux éliminer de la recherche et de la pratique clinique. Les obstacles à une telle élimination sont repérés, et nous discutons des stratégies pour les surmonter.The paper presents arguments for the claim that the concept of schizophrenia is a harmful stereotype that is best eliminated from research and clinical practice. Obstacles to such elimination are identified and strategies for overcoming them are discussed

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ADHD and Genetics: A Consensus Reconsidered

Joseph¹

2009

Rethinking ADHD

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Intermediate Phenotypes in Genetic Studies of Schizophrenia

Cited by 4 publications

References 293 publications

Recognition and optimal management of schizophrenia and related psychoses

Recognition and optimal management of schizophrenia and related psychoses

Étapes vers un monde sans schizophrénie

ADHD and Genetics: A Consensus Reconsidered

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