Intermittent Cholestatic Jaundice and Nonmetastatic Prostatic Carcinoma

Reddy, Atigadda N.; Grosberg, Saul J.; Wapnick, S

doi:10.1001/archinte.1977.03630230088024

Cited by 14 publications

(7 citation statements)

References 6 publications

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“…Three of those cases had paraneoplastic cholestasis. [1][2][3] Another three had main bile duct obstruction 16,17,26 and the others were diagnosed with secondary biliary cirrhosis 22 and sclerosing cholangitis. 23 Our case had no signs of obstruction of bile flow, neoplastic involvement of the liver, or infectious etiology.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] Systemic and/or local intrahepatic proinflammatory cytokines are assumed to inhibit hepatocellular bile secretion. There is evidence that those cytokines are potent inhibitors of hepatobiliary transporter gene expression, resulting in hyperbilirubinemia and cholestasis.…”

mentioning

confidence: 99%

“…İbrahim ERTUĞRUL, MD, 17 Intrahepatic cholestasis without mechanical obstruction has been previously reported in only three prostate carcinoma cases in the English literature. [1][2][3] In this report, we described a new case of paraneoplastic intrahepatic cholestasis in a patient with prostate carcinoma. We also discussed the mechanisms of cholestasis in prostate carcinoma in the light of the pertinent literature.…”

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confidence: 99%

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Paraneoplastic Cholestasis in Prostate Carcinoma: A Case Report and Review of the Literature

Ertuğrul¹,

Başar²,

Ödemiş³

et al. 2010

Turkiye Klinikleri J Med Sci

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1756ntrahepatic cholestasis is a rare manifestation of paraneoplastic syndrome and has been reported to be associated with various malignancies. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Systemic and/or local intrahepatic proinflammatory cytokines are assumed to inhibit hepatocellular bile secretion. There is evidence that those cytokines are potent inhibitors of hepatobiliary transporter gene expression, resulting in hyperbilirubinemia and cholestasis. 15 Prostate carcinoma associated with cholestasis may be due to mechanical bile duct obstruction by the liver metastasis 16 or enlarged lymph Paraneoplastic Cholestasis in Prostate Carcinoma: A Case Report and Review of the Literature A AB BS S T TR RA AC CT T In tra he pa tic cho les ta sis is a ra re ma ni fes ta ti on of pa ra ne op las tic syndro me and has been re por ted to be as so ci a ted with va ri o us ma lig nan ci es. In tra he pa tic cho les ta sis wit ho ut a mec hani cal obs truc ti on has be en pre vi o usly re por ted in only thre e pros ta te car ci no ma ca ses in Eng lish li te ra tu re. In this re port, we des cri bed a new ca se of pa ra ne op las tic in tra he pa tic cho les ta sis in a pati ent with pros ta te car ci no ma tre a ted only with bi la te ral orc hi ec tomy. We al so dis cus sed the mecha nisms of cho les ta sis in pros ta te car ci no ma in the light of the per ti nent li te ra tu re. Pa ra ne op las tic cho les ta sis sho uld be kept in mind in the ab sen ce of bi li ary tract obs truc ti on and he pa tic in vol vement in pros ta te car ci no ma. Pa ti ents with unexp la i ned cho les ta sis sho uld be in ves ti ga ted for a possib le pa ra ne op las tic syndro me. Pa ra ne op las tic cho les ta sis re sol ves fol lo wing orc hi ec tomy in pros ta te car ci no ma ca ses.K Ke ey y W Wo or rd ds s: : Cho les ta sis, in tra he pa tic; pa ra ne op las tic syndro mes; pros ta tic ne op lasms Ö ÖZ ZE ET T İntra he pa tik ko les taz, pa ra ne op las tik sendromun na dir bir gös ter ge si olup çe şit li ma lig ni teler le bir lik te li ği bil di ril miş tir. Pros tat kan se rin de me ka nik obs trük si yon ol mak sı zın ge li şen in trahe pa tik ko les taz, İngi liz li te ra tü rün de da ha ön ce sa de ce üç ol gu da su nul muş tur. Bu ra da, sa de ce bi la te ral or şi ek to mi ile pa ra ne op las tik in tra he pa tik ko les ta zı te da vi edi len, pros tat kan ser li ye ni bir ol gu sun duk. Ay rı ca, bu ko nu ile il gi li li te ra tür ler eş li ğin de pros tat kan se rin de ko les ta zın me ka nizma la rı nı da tar tış tık. Pa ra ne op las tik ko les tazın, pros tat kan se rin de he pa tik tu tu lum ve bi li yer obstrük si yon ol mak sı zın ge li şe bi le ce ği akıl da tu tul ma lı dır. Açık la na ma yan ko les taz lı has ta la r da pa ra ne op las tik sen drom araş tı rıl ma lı dır. Pa ra ne op las tik ko les taz pros tat kan ser li va ka lar da or şi ekto mi yi ta ki ben ge ri le mek te dir. İbrahim ERTUĞRUL, MD,

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Paraneoplastic Cholestasis in Prostate Carcinoma: A Case Report and Review of the Literature

Ertuğrul¹,

Başar²,

Ödemiş³

et al. 2010

Turkiye Klinikleri J Med Sci

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“…Although uncommon, reversible hepatic dysfunction in prostate cancer has been described in nine published cases (Table I) (1,(13)(14)(15)(16)(17)(18)(19)(20). All reported cases occurred in patients with metastatic disease.…”

Section: Reversible Intrahepatic Cholestasis In Metastatic Prostatementioning

confidence: 99%

“…Reversible cholestasis without evidence of biliary obstruction has been reported to occur in association with a variety of malignancies, most notably Stauffer's Syndrome in renal cell carcinoma. Intrahepatic cholestasis occurring in the setting of advanced prostate adenocarcinoma has less commonly been described with the first case reported in 1977 (1). Furthermore, the pathogenesis of this syndrome remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome

et al. 2018

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Abstract.As with other genitourinary malignancies, a variety of paraneoplastic syndromes have been revealed to occur in patients with prostate cancer. Stauffer's Syndrome is a well-described clinical syndrome which manifests via intrahepatic cholestasis in patients with renal cell carcinoma. Less common is intrahepatic cholestasis occurring in association with prostate cancer. The current case report discusses a 67-year-old man presenting with liver failure secondary to intrahepatic cholestasis co-existing with metastatic prostate adenocarcinoma. The patient's liver failure completely resolved with androgen-deprivation therapy suggesting an association between these two entities. The case report evaluates existing literature on this uncommon syndrome including the clinical presentation, natural history, and potential pathophysiology.

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Epilogue

Hafez¹

1981

Prostatic Carcinoma

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Intermittent Cholestatic Jaundice and Nonmetastatic Prostatic Carcinoma

Cited by 14 publications

References 6 publications

Paraneoplastic Cholestasis in Prostate Carcinoma: A Case Report and Review of the Literature

Paraneoplastic Cholestasis in Prostate Carcinoma: A Case Report and Review of the Literature

Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome

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