Intermittent cocaine self-administration has sex-specific effects on addiction-like behaviors in rats

Bender, Brooke N.; Torregrossa, Mary M.

doi:10.1016/j.neuropharm.2023.109490

Cited by 7 publications

(3 citation statements)

References 43 publications

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“…We found no sex difference in punishment resistance for cocaine, but found increased punishment resistance in males for food, as compared to females. Previous studies have shown female rats to be more sensitive to punishment for cocaine and more sensitive to punishment with risky food rewards [ 28 , 50 , 51 , 82 , 83 ]. Females also appeared to show greater punishment resistance for cocaine than food [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

“…While habitual responding develops in the majority of rats after extended training on cocaine self-administration [ 25 , 26 ], punishment resistance develops in only a subset of rats [ 2 , 3 , 27 ]. DLS is necessary for habitual responding for cocaine and is progressively recruited over extended cocaine training [ 13 , 25 , 28 – 32 ]. DLS may also play a role in punishment resistance for cocaine, considering that DLS inactivation increased sensitivity to footshock punishment [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Punishment resistance for cocaine is associated with inflexible habits in rats

Jones,

Paladino,

Cruz

et al. 2024

Addiction Neuroscience

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Punishment resistance for cocaine is associated with inflexible habits in rats

Jones,

Paladino,

Cruz

et al. 2024

Addiction Neuroscience

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“…Estrous cycle phase was determined daily by cellular morphology as previously described [ 65 , 66 ].…”

Section: Methodsmentioning

confidence: 99%

Changes in dorsomedial striatum activity during expression of goal-directed vs. habit-like cue-induced cocaine seeking

Bender,

Stringfield,

Torregrossa

2024

Addiction Neuroscience

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The positive reinforcing effects of cocaine and opposite-sex social contact: roles of biological sex and estrus

Smith,

Armas,

Camp

et al. 2024

Psychopharmacology

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Rationale Preclinical studies report that drug use and social contact mutually influence the reinforcing effects of one another. Most of these studies have used same-sex dyads exclusively, and the role of factors related to biological sex and hormonal fluctuations are not well understood. Objectives The purpose of this study was to examine the reinforcing effects of cocaine and social contact with an opposite-sex partner in male and female rats, and how these effects are modulated by ovarian hormones. Methods Male and female rats were trained in a nonexclusive choice procedure in which cocaine and social contact with an opposite-sex partner were simultaneously available on concurrent progressive ratio schedules of reinforcement. To examine the effects of ovarian hormones related to estrous cycling, Experiment 1 used naturally cycling, gonadally intact females, whereas Experiment 2 used ovariectomized females, and estrus was artificially induced with exogenous hormones. Results In both experiments, cocaine and social contact functioned as robust reinforcers, and there were no significant effects of biological sex or estrus status of the females. The positive reinforcing effects of both cocaine and social contact increased as a function of cocaine dose, indicating that contingent cocaine administration increases the reinforcing effects of social contact. Conclusions These data suggest that cocaine use among opposite-sex partners may enhance factors that contribute to social bonding.

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Intermittent cocaine self-administration has sex-specific effects on addiction-like behaviors in rats

Cited by 7 publications

References 43 publications

Punishment resistance for cocaine is associated with inflexible habits in rats

Punishment resistance for cocaine is associated with inflexible habits in rats

Changes in dorsomedial striatum activity during expression of goal-directed vs. habit-like cue-induced cocaine seeking

The positive reinforcing effects of cocaine and opposite-sex social contact: roles of biological sex and estrus

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