2022
DOI: 10.1101/2022.12.19.521063
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Intermittent cocaine self-administration has sex-specific effects on addiction-like behaviors in rats

Abstract: Intermittent access (IntA) models of cocaine self-administration were developed to better model in rodents how cocaine is used by human drug users. Compared to traditional continuous access (ContA) models, IntA has been shown to enhance several pharmacological and behavioral effects of cocaine, but few studies have examined sex differences in IntA. Moreover, no one has examined the efficacy of cue extinction to reduce cocaine seeking in the IntA model, which has previously shown to be ineffective in other mode… Show more

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