Intermittent Fasting and Human Metabolic Health

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

“…Although many agents and treatments were reported to induce browning (Bonet et al, 2013; Jiang et al, 2015; Wu et al, 2013), it is unclear how these approaches can translate to clinically-relevant therapies for human metabolic disease (Nedergaard and Cannon, 2014). In contrast, intermittent fasting (including EODF) has been practiced in humans, especially in certain religious groups (Patterson et al, 2015), for centuries, and has proven to benefit body composition and health (Eshghinia and Mohammadzadeh, 2013; Lopez-Bueno et al, 2014; Patterson et al, 2015). To date, few studies have looked at whether this regimen can induce WAT beiging.…”

Intermittent Fasting as a Novel Treatment Approach for Patients Treated with Atypical Antipsychotics

“…Intermittent fasting in particular has expanded from periodic fasting for periods longer than 24 hours to more innovative fasting structures such as alternate day fasting, modified fasting regimens and time-restricted feeding windows [18]. For the purposes of our research, we have omitted all religious fasting.…”

“…Periods typically range from 12 hours to 3 weeks [20], dependent on the objective and amount of stored adipose tissue. A fasting review by Patterson et al suggests intermittent fasting is "hypothesized to influence metabolic regulation via effects on circadian biology, the gastrointestinal microbiota, and modifiable lifestyle behaviors" [18]. Absent changes in total caloric intake, intermittent fasting has been consistently shown to improve health and function [21] in both animal and human models.…”

“…Absent changes in total caloric intake, intermittent fasting has been consistently shown to improve health and function [21] in both animal and human models. The most notable health outcomes include obesity prevention, decreased risk of type 2 diabetes and decreased prevalence of cancer and cardiovascular disease [18,20]. In animal studies conducted by Chaix et al [22] it was shown that 8-hour feeding windows protected mice against obesity when faced with diverse nutritional challenges ranging from fructose, fat and sucrose based diets.…”

Therapeutic fasting as a potential effective treatment for type 2 diabetes: A 4-month case study

“…16 Another review found randomised control trials of fasting to have Lifestyle therapy is an integral part of type 2 diabetes (T2D) management, but there remains no consensus on an optimal diet. The objective of this study is to evaluate the efficacy of therapeutic fasting as a treatment for T2D.…”