Intermittent fasting reverses the declining quality of aged oocytes

Li, Chan; Zhang, Hui; Wu, Hao; Li, Ruoyu; Wen, Dongxu; Tang, Yaju; Gao, Zhen; Xu, Rui; Lu, Sihai; Wei, Qiang; Zhao, Xiaoe; Pan, Meng-Hao; Ma, Baohua

doi:10.1016/j.freeradbiomed.2022.12.084

Cited by 10 publications

(6 citation statements)

References 74 publications

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“…However, early-adulthood IF decreased self-fertile reproduction while adulthood-only rIIS had no impact. These findings are consistent with previous research where various forms of dietary restriction, including intermittent fasting, reduced reproduction during food shortage while retarding reproductive ageing (C. Li et al, 2023; G. Y. Li & Zhang, 2019; Mendenhall et al, 2011; Sultanova et al, 2021).…”

Section: Discussionsupporting

confidence: 93%

“…Furthermore, while reduced IIS improves reproductive ageing in benign environments, it is not clear whether such effects will manifest in more natural conditions when the organisms are exposed to temporary food shortages. Interestingly, different forms of food shortages, such as continuous dietary restriction (reduced intake of nutrients without malnutrition) or intermittent fasting (IF) (aka time-restricted fasting) also can extend reproductive lifespan ( 16 , 17 ). However, it is not clear whether such effects are underpinned by the same molecular pathways.…”

Section: Introductionmentioning

confidence: 99%

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Optimising age-specific insulin signalling to slow down reproductive ageing increases fitness in different environments

Sultanova,

Shen,

Hencel

et al. 2023

Preprint

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Intermittent fasting (IF) and reduced insulin/IGF-1 nutrient-sensing signalling (rIIS) increase lifespan via partially shared downstream genetic pathways. The relationship between IF and rIIS is unclear because IF reduces reproduction, while adulthood-only rIIS does not. Here, we show that early-adulthood (but not late-adulthood) IF and adulthood-only rIIS additively increase lifespan and slow reproductive ageing inC. elegans. Mechanistically, we show that in the combined IF + rIIS treatment, nuclear localisation of DAF-16 transcription factor is primarily driven by IF in early-life, and primarily driven by rIIS in late-life. Full factorial genome-wide RNA-seq across the life course demonstrates that early-adulthood IF and rIIS modulate the age-specific expression of pro-longevity genes. Early-adulthood IF, rIIS and combined IF + rIIS treatment downregulated genes involved in peptide metabolism in early life and differentially regulated immunity genes in later life. Importantly. combined IF + rIIS treatment uniquely regulated a large cluster of genes in mid-life that are associated with immune response. These results suggest that the combined impact of different treatments aimed at healthy ageing can achieve better outcomes by targeting different ages.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Optimising age-specific insulin signalling to slow down reproductive ageing increases fitness in different environments

Sultanova,

Shen,

Hencel

et al. 2023

Preprint

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“…Dietary regulation can also impact oocyte oxidative stress. For example, intermittent fasting can improve oocyte quality by restoring the NAD + /Sirt1-mediated antioxidant defense system, which can eliminateexcessive ROS accumulation [304].…”

Section: Antioxidantmentioning

confidence: 99%

Ovarian aging: energy metabolism of oocytes

Bao,

Yin,

Liu

2024

J Ovarian Res

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In women who are getting older, the quantity and quality of their follicles or oocytes and decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, and lower quality oocytes. As more women choose to delay childbirth, the decline in fertility associated with age has become a significant concern for modern women. The decline in oocyte quality is a key indicator of ovarian aging. Many studies suggest that age-related changes in oocyte energy metabolism may impact oocyte quality. Changes in oocyte energy metabolism affect adenosine 5'-triphosphate (ATP) production, but how related products and proteins influence oocyte quality remains largely unknown. This review focuses on oocyte metabolism in age-related ovarian aging and its potential impact on oocyte quality, as well as therapeutic strategies that may partially influence oocyte metabolism. This research aims to enhance our understanding of age-related changes in oocyte energy metabolism, and the identification of biomarkers and treatment methods.

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“…In addition to the fact that macrophages were attenuated in aging ovaries, they also noted for the first time that the most obvious change in the ovaries of premenopausal aging female mice is a shift from innate to adaptive immunity [127]. When it comes to relevant interventions, although intermittent fasting eliminates excessive accumulation of ROS through the nicotinamide adenine dinucleotide (NAD+)/Sirt1-mediated antioxidant defense system to inhibit DNA damage and apoptosis, and thus has a positive effect on aged mouse oocytes [121], its applicability to humans needs to be further explored. Supplementation with dehydroepiandrosterone (DHEA) and coenzyme Q10 (Q10) targeted upregulation of iron death-related genes resulted in reduced expression levels of these genes, altered glycolysis, and enhanced mitochondrial oxidative phosphorylation, which improved energy metabolism in oocytes from senescent patients and informed clinical interventions [128].…”

Section: The Findings Of Single-cell Studies In Physiology Of Follicu...mentioning

confidence: 99%

“…An interesting study suggests that intermittent feeding alleviates spindle structural abnormalities and chromosomal segregation errors in mice, maintains proper cytoplasmic organelle reorganization, and thus improves nuclear and cytoplasmic maturation in aged oocytes to enhance oocyte meiotic competence and embryonic development [121].…”

Section: Chromosome Abnormalitiesmentioning

confidence: 99%

Follicular development and ovary aging: single-cell studies

Zhao

Wang

Yang

2023

Biology of Reproduction

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Follicular development is a critical process in reproductive biology that determines the number of oocytes and interacts with various cells within the follicle (such as oocytes, granulosa cells, cumulus cells and theca cells, etc.), and plays a vital role in fertility and reproductive health due to the dogma of a limited number of oogonia. Dysregulation of follicular development can lead to infertility problems and other reproductive disorders. To explore the physiological and pathological mechanisms of follicular development, immunology-based methods, microarrays, and next-generation sequencing have traditionally been used for characterization at the tissue level. However, with the proliferation of single-cell sequencing techniques, research has uncovered unique molecular mechanisms in individual cells that have been masked by previous holistic analyses. In this review, we briefly summarize the achievements and limitations of traditional methods in the study of follicular development. Simultaneously, we focus on how to understand the physiological process of follicular development at the single-cell level and reveal the relevant mechanisms leading to the pathology of follicular development and intervention targets. Moreover, we also summarize the limitations and application prospects of single cell sequencing in follicular development research.

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Intermittent fasting reverses the declining quality of aged oocytes

Cited by 10 publications

References 74 publications

Optimising age-specific insulin signalling to slow down reproductive ageing increases fitness in different environments

Optimising age-specific insulin signalling to slow down reproductive ageing increases fitness in different environments

Ovarian aging: energy metabolism of oocytes

Follicular development and ovary aging: single-cell studies

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