Intermittent fetal bradycardia induced by midpregnancy fetal ultrasonographic study

Mendoza, Glenn J.; Almeida, Orlandino D.; Steinfeld, Leonard

doi:10.1016/0002-9378(89)90155-5

Cited by 13 publications

(5 citation statements)

References 4 publications

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“…Other authors however described the higher level of the PPARγ expression in human psoriatic skin compared to healthy skin. But the level of PPARγ mRNA was close to the detection limit in their research [20].…”

Section: Discussionmentioning

confidence: 54%

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Analysis of PPARγ Signaling Activity in Psoriasis

Соболев

Nesterova

Соболева

et al. 2021

IJMS

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In our previous work, we built the model of PPARγ dependent pathways involved in the development of the psoriatic lesions. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which regulates the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions triggering the IL17-related signaling cascade. Skin samples of normally looking and lesional skin donated by psoriasis patients and psoriatic CD3+ Tcells samples (n = 23) and samples of healthy CD3+ T cells donated by volunteers (n = 10) were analyzed by real-time PCR, ELISA and immunohistochemistry analysis. We found that the expression of PPARγ is downregulated in human psoriatic skin and laser treatment restores the expression. The expression of IL17, STAT3, FOXP3, and RORC in psoriatic skin before and after laser treatment were correlated with PPARγ expression according to the reconstructed model of PPARγ pathway in psoriasis.In conclusion, we report that PPARγ weakens the expression of genes that contribute in the development of psoriatic lesion. Our data show that transcriptional regulation of PPARγ expression by FOSL1 and by STAT3/FOSL1 feedback loop may be central in the psoriatic skin and T-cells.

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Section: Discussionmentioning

confidence: 54%

“…While the prominent role of RORC in psoriasis as the major controller of Th17 cell differentiation is well described, however, the evidence of RORC expression in psoriasis is controversial. In mice T-cells and dendritic cells had increased STAT3/RORC expression [18] and patients with psoriasis had elevated level of RORC (RORG-t isoform) [20].…”

Section: Figurementioning

confidence: 99%

Analysis of PPARγ Signaling Activity in Psoriasis

Соболев

Nesterova

Соболева

et al. 2021

IJMS

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“…While the prominent role of RORC in psoriasis as the major controller of Th17 cell differentiation is well described, however, the evidence of RORC expression in psoriasis is controversial and supported by work where mice T-cells and dendritic cells had increased STAT3/RORC expression (Nadeem et al, 2017) still patients with psoriasis had elevated level of RORC (RORG-t isoform) (Mendoza et al, 1989). In analysed published microarray data, the level of expression of RORC was downregulated in most of 58 patients.…”

Section: Resultsmentioning

confidence: 99%

THE MODEL OFPPARγDOWNREGULATED SIGNALING IN PSORIASIS

Соболев

Nesterova

Соболева

et al. 2020

Preprint

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Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of PPARγ downregulated signaling in psoriasis. We found that the expression of PPARγ maybe be slightly downregulated in human psoriatic skin and laser treatment may facilitate it. We tested the reconstructed model and found that at least on mRNA level the expression of IL17, STAT3, FOXP3, and RORC and FOSL1 genes in psoriatic skin before and after laser treatment were correlated with the level of PPARγ mRNA expression suggesting that genes belong to the same signaling pathway that may regulate the development of psoriasis lesion.

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“…While the prominent role of RORC in psoriasis as the major controller of Th17 cell differentiation is well described, however, the evidence of RORC expression in psoriasis is controversial and supported by work where mice T cells and dendritic cells had increased STAT3/RORC expression [ 48 ]; still, patients with psoriasis had elevated level of RORC (RORG-t isoform) [ 49 ]. In analysed published microarray data, the level of expression of RORC was downregulated in most of 58 patients.…”

Section: Discussionmentioning

confidence: 99%

The Model of PPARγ-Downregulated Signaling in Psoriasis

et al. 2020

View full text Add to dashboard Cite

Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of PPARγ-downregulated signaling in psoriasis. We hypothesize that the expression of IL17, STAT3, FOXP3, and RORC and FOSL1 genes in psoriatic skin is correlated with the level of PPARγ expression, and they belong to the same signaling pathway that regulates the development of psoriasis lesion.

show abstract

Intermittent fetal bradycardia induced by midpregnancy fetal ultrasonographic study

Cited by 13 publications

References 4 publications

Analysis of PPARγ Signaling Activity in Psoriasis

Analysis of PPARγ Signaling Activity in Psoriasis

THE MODEL OFPPARγDOWNREGULATED SIGNALING IN PSORIASIS

The Model of PPARγ-Downregulated Signaling in Psoriasis

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