Intermittent Hypoxia–Hyperoxia Conditioning Improves Cardiorespiratory Fitness in Older Comorbid Cardiac Outpatients Without Hematological Changes: A Randomized Controlled Trial

Дудник, Е. Н.; Zagaynaya, Elena; Глазачев, О. С.; Суста, Давиде

doi:10.1089/ham.2018.0014

Cited by 33 publications

(67 citation statements)

References 14 publications

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“…A recent study that evaluated the effects of IHHT on patients with MCI (64–92 years of age) has shown significant improvements in the cognitive state and physical endurance [37]. These findings were also in accordance with the study results from another research group [27,30].…”

Section: Discussionsupporting

confidence: 83%

“…There is growing evidence supporting the notion that sessions of brief repeated, controllable exposures to moderate levels of hypoxia, termed as intermittent hypoxia-normoxia training (IHT) or intermittent hypoxia-hyperoxia training (IHHT), may improve cerebral vascular function and mitochondrial energy production, same as those that have been demonstrated in sports training and/or rehabilitative medicine. For instance, IHT has beneficial effects on elderly health [27,28,29]. During the past decade, a modified intermittent hypoxia training method, i.e., IHHT, was introduced and applied in several human studies or clinical trials in several European countries [27,30,31].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, IHT has beneficial effects on elderly health [27,28,29]. During the past decade, a modified intermittent hypoxia training method, i.e., IHHT, was introduced and applied in several human studies or clinical trials in several European countries [27,30,31]. The underlying cellular mechanisms of IHT or IHHT may include the improvement of mitochondrial function, regulation of glucose transport, activation of antioxidant enzyme system, as well as anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

Serebrovska

Kholin

et al. 2019

IJMS

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Alzheimer’s disease (AD) affects not only the central nervous system, but also peripheral blood cells including neutrophils and platelets, which actively participate in pathogenesis of AD through a vicious cycle between platelets aggregation and production of excessive amyloid beta (Aβ). Platelets adhesion on amyloid plaques also increases the risk of cerebral microcirculation disorders. Moreover, activated platelets release soluble adhesion molecules that cause migration, adhesion/activation of neutrophils and formation of neutrophil extracellular traps (NETs), which may damage blood brain barrier and destroy brain parenchyma. The present study examined the effects of intermittent hypoxic-hyperoxic training (IHHT) on elderly patients with mild cognitive impairment (MCI), a precursor of AD. Twenty-one participants (age 51–74 years) were divided into three groups: Healthy Control (n = 7), MCI+Sham (n = 6), and MCI+IHHT (n = 8). IHHT was carried out five times per week for three weeks (total 15 sessions). Each IHHT session consisted of four cycles of 5-min hypoxia (12% FIO2) and 3-min hyperoxia (33% FIO2). Cognitive parameters, Aβ and amyloid precursor protein (APP) expression, microRNA 29, and long non-coding RNA in isolated platelets as well as NETs in peripheral blood were investigated. We found an initial decline in cognitive function indices in both MCI+Sham and MCI+IHHT groups and significant correlations between cognitive test scores and the levels of circulating biomarkers of AD. Whereas sham training led to no change in these parameters, IHHT resulted in the improvement in cognitive test scores, along with significant increase in APP ratio and decrease in Aβ expression and NETs formation one day after the end of three-week IHHT. Such effects on Aβ expression and NETs formation remained more pronounced one month after IHHT. In conclusion, our results from this pilot study suggested a potential utility of IHHT as a new non-pharmacological therapy to improve cognitive function in pre-AD patients and slow down the development of AD.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

Serebrovska

Kholin

et al. 2019

IJMS

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“…Согласно анализу данных, представленных в 11 отобранных публикациях, из 320 пациентов подавляющее большинство -пациенты пожилого возраста с сопутствующей артериальной гипертензией (АГ). После курса ИГГТ/ИГТ у пациентов отмечалось значимое снижение частоты сердечных сокращений, систолического артериального давления (АД) (САД) и диастолического АД по сравнению с контрольной группой [16][17][18][19]. Более того, показано, что курс гипоксической терапии сопровождается снижением уровня холестерина и липопротеидов низкой плотности, но без клинически значимой разницы [16,18,20].…”

Section: эффективность метода гипоксического кондиционирования в программах кардиореабилитацииunclassified

“…Более того, показано, что курс гипоксической терапии сопровождается снижением уровня холестерина и липопротеидов низкой плотности, но без клинически значимой разницы [16,18,20]. С точки зрения гематологических параметров, таких как гемоглобин, эритроциты и ретикулоциты, значительного эффекта гипоксического воздействия не было [16,[18][19][20][21]. Значимой разницы пикового потребления кислорода между гипоксической и плацебо-группами к окончанию курса выявлено не было, однако в ряде работ был продемонстирован достоверно значимый прирост пикового потребления кислорода у пациентов гипоксической группы по сравнению с изначальным уровнем [16,18,19,21].…”

Section: эффективность метода гипоксического кондиционирования в программах кардиореабилитацииunclassified

Intermittent hypoxic conditioning: experience and potential in cardiac rehabilitation programs

Глазачев

Лямина

Spirina³

2021

Russ J Cardiol

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The review describes the experience in intermittent hypoxic conditioning protocols in rehabilitation programs for patients with cardiovascular diseases. Based on randomized controlled trials, the efficacy and safety of intermittent hypoxic conditioning in patients with cardiovascular disease, including those with multicomorbidity in clinical practice, have been analyzed. From a physiological and clinical standpoints, the review justifies the need for further controlled clinical trials on hypoxic conditioning with a longer follow-up period both to expand the clinical indications for this method and to develop optimal combinations with exercise within cardiac rehabilitation programs. Discovery of the key mechanisms of adaptation to oxygen concentration changes and further research on hypoxia physiology will expand the application of this method in clinical and rehabilitation medicine in cardiac patients.

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Intermittent Hypoxic–Hyperoxic Training During Inpatient Rehabilitation Improves Exercise Capacity and Functional Outcome in Patients With Long Covid: Results of a Controlled Clinical Pilot Trial

Doehner,

Fischer,

Alimi

et al. 2024

J cachexia sarcopenia muscle

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IntroductionLong COVID‐19 illness is a severely disabling disease with shortness of breath, weakness and fatigue as leading symptoms, resulting in poor quality of life and substantial delay in return to work.No specific respiratory therapy has been validated for patients with long COVID. The intermittent hypoxia–hyperoxia training (IHHT) is a respiratory therapeutic modality to improve exercise performance via controlled respiratory conditioning. The purpose of the present study is to investigate the therapeutic effect of IHHT on functional and symptomatic recovery of patients with long COVID syndrome.MethodsA prospective, controlled, open‐treatment interventional study was conducted in patients with long COVID who were admitted to an inpatient rehabilitation programme. Patients were assigned nonrandomized to receive IHHT in addition to the standardized rehabilitation programme (IHHT group) or standard rehabilitation alone (control group). The IHHT group received supervised sessions of intermittent hypoxic (10–12% O2) and hyperoxic (30–35% O2) breathing three times per week throughout the rehabilitation period. Primary endpoint was improved walking distance in a 6‐min walk test (6MWT) between study groups. Secondary endpoints were change in stair climbing power, dyspnoea (Borg dyspnoea Scale), fatigue assessment scale (FAS) and change in health‐related quality of life (HRQoL) assessed by patient global assessment (PGA), EQ‐5D analogue scale and the MEDIAN Corona Recovery Score (MCRS). Further assessments included maximum handgrip strength, nine hole peg test, timed up‐and‐go, respiratory function and functional ambulation category (FAC), serum analyses and safety of the intervention.ResultsA total of 145 patients were included in the study (74% female, mean age 53 ± 12 years) and assigned to IHHT (n = 70) or standard care (n = 75). The 6MWT distance improved 2.8‐fold in the IHHT group compared to the control group (91.7 ± 50.1 m vs. 32.6 ± 54.2 m, ANCOVA p < 0.001). Stair climbing power improved 3.7‐fold in the IHHT group compared to controls (−1.91 ± 2.23 s vs. −0.51 ± 1.93 s, p < 0.001). Secondary endpoints on dyspnoea, fatigue and HRQoL (PGA, EQ‐5D and MCRS) improved significantly in the IHHT group compared to controls. The IHHT group exhibited a significant decrease in blood pressure, heart rate and increase in haemoglobin levels that was not observed in the control group. No adverse events were observed.ConclusionRespiratory treatment with IHHT in addition to a multidisciplinary rehabilitation programme improves functional capacity, symptomatic status and quality of life in patients with disabling long COVID. IHHT has been demonstrated to be safe, well tolerated and feasible to be integrated in an inpatient rehabilitation programme to improve outcome in long COVID.

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Intermittent Hypoxia–Hyperoxia Conditioning Improves Cardiorespiratory Fitness in Older Comorbid Cardiac Outpatients Without Hematological Changes: A Randomized Controlled Trial

Cited by 33 publications

References 14 publications

RETRACTED: Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

RETRACTED: Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer’s Disease in Patients with Mild Cognitive Impairment: A Pilot Study

Intermittent hypoxic conditioning: experience and potential in cardiac rehabilitation programs

Intermittent Hypoxic–Hyperoxic Training During Inpatient Rehabilitation Improves Exercise Capacity and Functional Outcome in Patients With Long Covid: Results of a Controlled Clinical Pilot Trial

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