Intermittent hypoxia produces Alzheimer disease?

Yagishita, Sosuke; Hirasawa, Akira

doi:10.18632/oncotarget.18214

Cited by 8 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ischemic stroke is a widespread disease, and is the main source of hypoxic brain stress ( Ratan et al, 2007 ; Virani et al, 2020 ). Hypoxia can also be a pathological component associated with neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases ( Yagishita and Hirasawa, 2017 ; Snyder et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Митрошина

Savyuk

Ponimaskin

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Hypoxia is one of the most common pathological conditions, which can be induced by multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body’s adaptation to hypoxia is a highly important phenomenon in both health and disease. Most cellular responses to hypoxia are associated with a family of transcription factors called hypoxia-inducible factors (HIFs), which induce the expression of a wide range of genes that help cells adapt to a hypoxic environment. Basic mechanisms of adaptation to hypoxia, and particularly HIF functions, have being extensively studied over recent decades, leading to the 2019 Nobel Prize in Physiology or Medicine. Based on their pivotal physiological importance, HIFs are attracting increasing attention as a new potential target for treating a large number of hypoxia-associated diseases. Most of the experimental work related to HIFs has focused on roles in the liver and kidney. However, increasing evidence clearly demonstrates that HIF-based responses represent an universal adaptation mechanism in all tissue types, including the central nervous system (CNS). In the CNS, HIFs are critically involved in the regulation of neurogenesis, nerve cell differentiation, and neuronal apoptosis. In this mini-review, we provide an overview of the complex role of HIF-1 in the adaptation of neurons and glia cells to hypoxia, with a focus on its potential involvement into various neuronal pathologies and on its possible role as a novel therapeutic target.

show abstract

Section: Introductionmentioning

confidence: 99%

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Митрошина

Savyuk

Ponimaskin

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Hypoxia can cause abnormal structural and functional alterations, eventually leading to cell death [1]. Several studies have shown that damage to the brain due to loss of oxygen is closely related to neurodegenerative diseases such as vascular dementia, Alzheimer disease, and Parkinson disease [2,3]. In hypoxic brain, accumulation of hypoxia-inducible factor-1α (HIF-1α) can be observed in the several brain regions including the cerebral cortex and the hippocampus [4,5].…”

Section: Introductionmentioning

confidence: 99%

Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl2-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells

Yoo

Kim

et al. 2019

Int Neurourol J

View full text Add to dashboard Cite

Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain. The aim of the present study was to investigate the neuroprotective effect and the regulating hypoxic inducible factor of NRG1 in cobalt chloride (CoCl2) induced hypoxia. Methods: Hypoxia was induced in SH-SY5Y cells by CoCl2 treatment. SH-SY5Y cells were pretreated with NRG1 and then treated with CoCl2. Western blotting, immunocytochemistry, and lactate dehydrogenase (LDH) release assays were performed to examine neuroprotective properties of NRG1 in SH-SY5Y cells. Results: Our data showed that CoCl2 induced cytotoxicity and changes of hypoxia-inducible factor-1α (HIF-1α) and p53 expression in SH-SY5Y cells. However, pretreatment with NRG1 inhibited CoCl2-induced accumulation of HIF-1α and p53 stability. In addition, NRG1 significantly attenuated cell death of SH-SY5Y induced by CoCl2. Conclusions: NRG1 can regulate HIF-1α and p53 to protect neurons against hypoxic damage.

show abstract

“…Notably, studies indicate that modeling intermittent hypoxia in mice for 5 or 28 days induces alterations in genome methylation akin to aging, particularly affecting the metabolic cascades associated with neurogenesis, the cell cycle, and energy production, alongside an increase in phosphorylated tau protein [56].…”

Section: Neuroinflammationmentioning

confidence: 99%

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration

Mitroshina,

Vedunova

2024

IJMS

View full text Add to dashboard Cite

Understanding the molecular underpinnings of neurodegeneration processes is a pressing challenge for medicine and neurobiology. Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent the most prevalent forms of neurodegeneration. To date, a substantial body of experimental evidence has strongly implicated hypoxia in the pathogenesis of numerous neurological disorders, including AD, PD, and other age-related neurodegenerative conditions. Hypoxia-inducible factor (HIF) is a transcription factor that triggers a cell survival program in conditions of oxygen deprivation. The involvement of HIF-1α in neurodegenerative processes presents a complex and sometimes contradictory picture. This review aims to elucidate the current understanding of the interplay between hypoxia and the development of AD and PD, assess the involvement of HIF-1 in their pathogenesis, and summarize promising therapeutic approaches centered on modulating the activity of the HIF-1 complex.

show abstract

Intermittent hypoxia produces Alzheimer disease?

Cited by 8 publications

References 7 publications

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl2-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration

Contact Info

Product

Resources

About