Intermittent hypoxia revisited: a promising non-pharmaceutical strategy to reduce cardio-metabolic risk factors?

Costalat, Guillaume; Lemaître, F.; Tobin, Barbara M.; Renshaw, Gillian Mary Claire

doi:10.1007/s11325-017-1459-8

Cited by 23 publications

(18 citation statements)

References 14 publications

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“…Only one of these studies 39 did not include a physical activity program at altitude, therefore enabling the evaluation of the specific effects of hypoxic exposure independently of any change in physical activity. Although these studies reported some encouraging results regarding improved BMI, 39 cardiovascular (i.e., reduced blood pressure 39,83 and metabolic 82,83 ) status implemented during daytime [84][85][86] or during sleep. 87 Workman and…”

Section: Hypoxia As Treatmentmentioning

confidence: 99%

“…Costalat et al 84 Similar to strategies used by athletes in altitude training paradigms, 44 two randomized controlled studies evaluated the effect of combining hypoxic exposure and exercise training in subjects with obesity. 90,91 The results suggested that hypoxic exercise training may induce slightly greater improvements in body weight and composition than normoxic exercise training.…”

Section: Hypoxia As Treatmentmentioning

confidence: 99%

“…Intermittent hypoxic exposure similar to methods used by athletes to increase their performance 44 has been evaluated in pilot studies over the past years in the context of obesity. Passive (i.e., at rest, without exercise) intermittent hypoxic exposure has been implemented during daytime 84–86 or during sleep 87 . Workman and Basset 86 demonstrated that six sessions of 3‐h passive exposure to hypoxia (SpO 2 ~ 80%) increased energy expenditure and lipid oxidation in overweight males compared with sham normoxic sessions.…”

Section: Hypoxia As Treatmentmentioning

confidence: 99%

“…Workman and Basset 86 demonstrated that six sessions of 3‐h passive exposure to hypoxia (SpO 2 ~ 80%) increased energy expenditure and lipid oxidation in overweight males compared with sham normoxic sessions. Costalat et al 84 showed, in six individuals with overweight or obesity, ten 70‐min long sessions of intermittent hypoxia (~15 deoxygenations to SpO 2 = 80%—reoxygenation cycles) over 2 weeks reduced blood lipid levels (LDLc) and lowered systolic blood pressure. Marlatt et al 87 evaluated the effect of hypoxic exposure during nighttime only (sleeping in a hypoxic tent at home) for 14 consecutive nights in patients with obesity and type II diabetes.…”

Section: Hypoxia As Treatmentmentioning

confidence: 99%

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Hypoxia, energy balance, and obesity: An update

Kayser

Vergès

2021

Obesity Reviews

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Because of the enduring rise in the prevalence of obesity worldwide, there is continued interest in hypoxia as a mechanism underlying the pathophysiology of obesity and its comorbidities and as a potential therapeutic adjunct for the management of the disease. Lifelong exposure to altitude is accompanied by a lower risk for obesity, whereas altitude sojourns are generally associated with a loss of body mass. A negative energy balance upon exposure to hypoxia can be due to a combination of changes in determinants of energy expenditure (resting metabolic rate and physical activity energy expenditure) and energy intake (appetite). Over the past 15 years, the potential therapeutic interest of hypobaric or normobaric hypoxic exposure in individuals with obesity-to lower body mass and improve health status-has become an active field of research. Various protocols have been implemented, using actual altitude sojourns or intermittent normobaric hypoxic exposures, at rest or in association with physical activity. Although several studies suggest benefits on body mass and cardiovascular and metabolic variables, further investigations are required before recommending hypoxic exposure in obesity management programs. Future studies should also better clarify the effects of hypoxia on appetite, the intestinal microbiota, and finally on overall energy balance.

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Section: Hypoxia As Treatmentmentioning

confidence: 99%

Section: Hypoxia As Treatmentmentioning

confidence: 99%

Section: Hypoxia As Treatmentmentioning

confidence: 99%

Section: Hypoxia As Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Hypoxia, energy balance, and obesity: An update

Kayser

Vergès

2021

Obesity Reviews

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“…Intermittent hypoxia intervention (IHI) has been explored as a means of therapy for health conditions in the past decades [ 4 – 8 ]. The term ‘IHI’ used in this article refers to repeated episodes of exposure to hypoxia separated by normoxia conditions.…”

Section: Introductionmentioning

confidence: 99%

Effects of four weeks intermittent hypoxia intervention on glucose homeostasis, insulin sensitivity, GLUT4 translocation, insulin receptor phosphorylation, and Akt activity in skeletal muscle of obese mice with type 2 diabetes

et al. 2018

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AimsThe aims of this study were to determine the effects of four weeks of intermittent exposure to a moderate hypoxia environment (15% oxygen), and compare with the effects of exercise in normoxia or hypoxia, on glucose homeostasis, insulin sensitivity, GLUT4 translocation, insulin receptor phosphorylation, Akt-dependent GSK3 phosphorylation and Akt activity in skeletal muscle of obese mice with type 2 diabetes.MethodsC57BL/6J mice that developed type 2 diabetes with a high-fat-diet (55% fat) (fasting blood glucose, FBG = 13.9 ± 0.69 (SD) mmol/L) were randomly allocated into diabetic control (DC), rest in hypoxia (DH), exercise in normoxia (DE), and exercise in hypoxia (DHE) groups (n = 7, each), together with a normal-diet (4% fat) control group (NC, FBG = 9.1 ± 1.11 (SD) mmol/L). The exercise groups ran on a treadmill at intensities of 75–90% VO2max. The interventions were applied one hour per day, six days per week for four weeks. Venous blood samples were analysed for FBG, insulin (FBI) and insulin sensitivity (QUICKI) pre and post the intervention period. The quadriceps muscle samples were collected 72 hours post the last intervention session for analysis of GLUT4 translocation, insulin receptor phosphorylation, Akt expression and phosphorylated GSK3 fusion protein by western blot. Akt activity was determined by the ratio of the phosphorylated GSK3 fusion protein to the total Akt protein.ResultsThe FBG of the DH, DE and DHE groups returned to normal level (FBG = 9.4 ± 1.50, 8.86 ± 0.94 and 9.0 ± 1.13 (SD) mmol/L for DH, DE and DHE respectively, P < 0.05), with improved insulin sensitivity compared to DC (P < 0.05), after the four weeks treatment, while the NC and DC showed no significant changes, as analysed by general linear model with repeated measures. All three interventions resulted in a significant increase of GLUT4 translocation to cell membrane compared to the DC group (P < 0.05). The DE and DH showed a similar level of insulin receptor phosphorylation compared with NC that was significantly lower than the DC (P < 0.05) post intervention. The DH and DHE groups showed a significantly higher Akt activity compared to the DE, DC and NC (P < 0.05) post intervention, as analysed by one-way ANOVA.ConclusionsThis study produced new evidence that intermittent exposure to mild hypoxia (0.15 FiO2) for four weeks resulted in normalisation of FBG, improvement in whole body insulin sensitivity, and a significant increase of GLUT4 translocation in the skeletal muscle, that were similar to the effects of exercise intervention during the same time period, in mice with diet-induced type 2 diabetes. However, exercise in hypoxia for four weeks did not have additive effects on these responses. The outcomes of the research may contribute to the development of effective, alternative and complementary interventions for management of hyperglycaemia and type 2 diabetes, particularly for individuals with limitations in participation of physical activity.

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Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients

et al. 2019

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Intermittent hypoxia revisited: a promising non-pharmaceutical strategy to reduce cardio-metabolic risk factors?

Abstract: A short course of recurrent IH appears to be a safe and effective non-pharmacological method of reducing key cardiovascular risk factors associated with metabolic disorders.

Cited by 23 publications

References 14 publications

Hypoxia, energy balance, and obesity: An update

Hypoxia, energy balance, and obesity: An update

Effects of four weeks intermittent hypoxia intervention on glucose homeostasis, insulin sensitivity, GLUT4 translocation, insulin receptor phosphorylation, and Akt activity in skeletal muscle of obese mice with type 2 diabetes

Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients

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