Intermittent intrathecal baclofen for severe tetanus

Demazière, J.; Vitris, M.; Marcoux, Louis-Alexandre; Saissy, J. M.; Seck, M; Ndiaye, Mamadou

doi:10.1016/0140-6736(91)91201-5

Cited by 16 publications

(11 citation statements)

References 3 publications

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“…(Demaziere et al 1991) (Tidyman et al 1985). However, their use is not widespread, and as baclofen must be administered intrathecally, its use is restricted to centres with suffi cient facilities to perform this safely.…”

Section: Other Muscle Relaxantsmentioning

confidence: 99%

Tetanus

Thwaites

2002

Pract Neurol

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Section: Other Muscle Relaxantsmentioning

confidence: 99%

Tetanus

Thwaites

2002

Pract Neurol

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“…Some clinicians have administered baclofen via repeated intrathecal injections because of the risk of secondary infection of the catheter [16], and others have administered it via continuous infusion. In 1986, Muller et al [17] reported 2 cases of tetanus that were successfully treated with an intrathecal bolus, with weaning from ventilatory support within 2 days.…”

Section: Discussionmentioning

confidence: 99%

“…The risk of secondary infection of an indwelling intrathecal catheter and of meningitis is increased when an indwelling intrathecal catheter is present in the subarachnoid space, so CSF analysis was performed for all patients initially, at weekly intervals, whenever fever occurred, and when the catheter was removed [11,16,18,19]. In our patients, the duration of perfusion ranged from 8 to 30 days ( , days).…”

Section: Discussionmentioning

confidence: 99%

Intrathecal Baclofen for the Treatment of Tetanus

et al. 2004

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Tetanus remains a serious problem in public health, particularly in developing countries, despite efficient prevention programs. A retrospective study was conducted at an infectious diseases intensive care unit during 1998-2003 involving patients admitted with grade III tetanus. The aim of the study was to evaluate the efficacy and safety of intrathecal baclofen for the treatment of tetanus. Lumbar puncture was performed, and a subarachnoid catheter was inserted for drug administration. An intrathecal bolus of baclofen was followed by a continuous infusion of 20 microg/h, until a maximum daily dose of 2 mg was provided. Twenty-two patients were treated overall. Control of the symptoms was achieved in all patients but one. Seven patients had colonization of the catheter, and 1 patient developed meningitis. All patients except one recovered. In our study, this means of treatment was efficacious and well tolerated.

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“…Most of the patients in other studies started treatment with a bolus dose in the range of 50-1000 m g (Table 2) [17,[21][22][23][24][25][26][27][28][29][30][31]. Some patients were treated thereafter only by repeated bolus injections on consecutive days [25,27,28], while other patients received a continuous infusion of baclofen.…”

Section: Discussionmentioning

confidence: 99%