Intermittent noise-induced hearing loss and the influence of carbon monoxide

Chen, Guang-Di; McWilliams, Misty L.; Fechter, Laurence D.

doi:10.1016/s0378-5955(99)00157-4

Cited by 41 publications

(21 citation statements)

References 30 publications

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“…111 Both carbon monoxide and cyanides have been found to potentiate permanent noise-induced hearing loss in animals and humans. 106,[112][113][114][115][116][117][118] This potentiation may be the result of a reduction in the cell's ability to repair noise-induced damage due to carbon monoxide poisoning. 112,113 What do epidemiological studies show?-In a large epidemiological investigation conducted by Lacerda et al, 118 the hearing thresholds of employees working in noisy occupational environments with combined carbon monoxide exposures were compared with the hearing thresholds of employees working in noisy occupational environments without carbon monoxide.…”

Section: Asphyxiantsmentioning

confidence: 99%

Chemical exposure and hearing loss

Campo¹,

Morata²,

Hong³

2013

Disease-a-Month

125

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Section: Asphyxiantsmentioning

confidence: 99%

Chemical exposure and hearing loss

Campo¹,

Morata²,

Hong³

2013

Disease-a-Month

125

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“…A programmable attenuator controlled the tone intensity, and the output of the attenuator was amplified by a high-voltage amplifier and then delivered to the sound transducer in the rat's external auditory meatus. Auditory thresholds were determined for tones of 2,4,6,8,12,16,20,24,30,35, and 40 kHz using tone bursts of 10-ms duration with a rise-fall time of 1.0 ms. The repetition rate of the tone bursts was 9.7 Hz.…”

Section: Assessment Of Auditory Thresholdmentioning

confidence: 99%

“…A series of publications from our laboratory have demonstrated that CO elevates sensitivity to permanent NIHL such that noise exposures that normally produce no permanent auditory threshold shift yield profound loss if CO is present along with the noise [5][6][7][8][9][10][11]. The extent of cochlear impairment is related to CO dose [9], but the loss of outer hair cells (OHCs) tends to occur preferentially in the base (highfrequency region) of the cochlea, even when noise energy is maximal within a relatively low (4.0-8.0 kHz) frequency band [7].…”

Section: Introductionmentioning

confidence: 99%

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Lipoic acid and 6-formylpterin reduce potentiation of noise-induced hearing loss by carbon monoxide: Preliminary investigation

Pouyatos

Gearhart²,

Nelson-Miller³

et al. 2008

JRRD

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Abstract-Potentiation of noise-induced hearing loss (NIHL) by specific chemical contaminants and therapeutic drugs represents a distinct public health risk. Prediction of chemicals that yield such potentiation has not been successful because such agents differ markedly in structure. One mechanism for this potentiation that has garnered support is oxidative injury to the cochlea. Thus far, limited data have been published in support of this hypothesis. The current experiment was designed to further test this model using two antioxidant compounds, lipoic acid (LA) and 6-formylpterin (6-FP), and determine whether they would block potentiation of NIHL resulting from simultaneous exposures to carbon monoxide (CO) and noise in rats. Neither CO nor noise exposure at the intensity and duration selected produce persistent auditory impairment by themselves. Different groups of rats were exposed to noise alone centered at 8.0 kHz (105 dB) for 2 hours or to combined CO + noise treatment consisting of CO exposure for 1.5 hours and then exposure to CO + noise for 2 hours. Additional groups received either LA (100 mg/kg) or 6-FP (14 mg/kg) 30 minutes prior to the onset of CO + noise. Cochlear function was monitored using distortion product otoacoustic emissions, and auditory thresholds were assessed using compound action potentials recorded from the round window. Histopathological evaluation of the organ of Corti provided counts of missing hair cells in each treatment group. The CO + noise-exposure group replicated previous studies in demonstrating permanent impairment of cochlear function and associated outer hair cell loss that greatly exceeded the minimal losses observed in the group treated with noise alone. Both LA and 6-FP given 30 minutes prior to the onset of CO + noise exposure reduced cochlear impairment and loss of hair cells.

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“…Furthermore, the balance and auditory central nervous system function might be also affected by solvent such that it is not expected from noise exposure alone. Similarly, NIHL has been found to be potentiated by some of air pollutants such as carbon monoxide (9)(10)(11)(12). In a study conducted on two groups of rabbits (one group exposed to noise and the second one exposed to noise plus carbon monoxide (CO); The noise group had a 44.9 dB threshold loss on 8th day and 20.3 dB threshold loss on 22nd day averaged across frequencies of 1-8 KHz, while animals receiving noise plus CO had a 58.4 dB and 27.8 dB average thresholdloss on 8th and 22nd days, respectively (2).…”

mentioning

confidence: 99%

Combined Effect of Noise and Chemical Substances on Hearing: What is Known and Future Research Needs.

Mirzaei

Ansari-Moghaddam

2013

Health Scope

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Noise induced hearing loss (NIHL) is one of the most prominent occupational diseases in all regions of the world which could be caused by exposure to loud sounds or noise at a work in wide spectrum of industries. Globally, it is accounting for 16% of the disabling hearing loss in adults (over 4 million DALYs) with a range of 7% to 21% in the differentsubregions(1,2). It has been estimated that more than 30 million workers in the United States of America and around 30 millions of people in European courtiers are exposed to loud sounds (defined as hazardous by WHO) which might result in hearing loss(3). Occupations at highest risk for NIHL include firemen, armed police, police motorcyclists, soldiers, construction and factory workers, printers, foundry workers, musicians, farmers, lorry drivers and miners. Noise is considered one of the most pervasive and harmful agents in crowded cities as well. In a study conducted in South Eastern city of Iran-Zahedan, approximately more than 80 % of the studied subjects ranked noise pollution too high at streets(4).Importantly, noise is no longer noticeable as the only source of work-related hearing loss and more attention is essential to the matter of joint risks for workers exposed to hazardous noise with work-related substances. Most threshold limit values are established for a single chemical substance and a single physical agent(5). However, the work environment is often composed of multiple chemical agent exampletoluene, styrene and benzene exposures and physical exposure such as noise, vibration and other stress.There is some evidence that employees exposed to the chemical substances suffered significantly from hearing impairment whereas noise levels were considerably lower than their corresponding individuals. The harmful effect of a chemical substance on ear function was first described by the Persian philosopher Avicenna (Abu Ali alHusaynibnAbd-AllahibnSinaBalkhi). He notified in his Canon of Medicine that using mercury vapor for treatment of head lice could causedeafness in patients(6). Accordingly, workers at the abovementioned occupations might be possibly exposed to multiple agents simultaneously. Combined Effect of Noise and Chemical Substances Mirzaei R et al. Health Scope. :() 156Interactions can occur in a variety of ways and by a number of mechanisms such as alterations in absorption, biotransformation and protein binding. The response of the organism to combinations of toxicants may be also increased or decreased because of the toxicological responses at the site of action. The effects of two chemicals can be additive when combined effect of two chemicals is equal to the sum of the effect of each agent (i.e. 2+3 equal 5), synergistic effect is the situation in which the combined effect of two chemicals is much greater than the sum of the effect of each agent given alone (i.e. 2+2 equal 20) and potentiation in which one substance does not have a toxic effect on a certain organ or system, but it makes the later much more toxic (i.e. 0 + 2 = 10) in addition to...

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Intermittent noise-induced hearing loss and the influence of carbon monoxide

Cited by 41 publications

References 30 publications

Chemical exposure and hearing loss

Chemical exposure and hearing loss

Lipoic acid and 6-formylpterin reduce potentiation of noise-induced hearing loss by carbon monoxide: Preliminary investigation

Combined Effect of Noise and Chemical Substances on Hearing: What is Known and Future Research Needs.

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