Intermittent Normobaric Hypoxic Exposures at Rest: Effects on Performance in Normoxia and Hypoxia

Mekjavic, Igor B.; Debevec, Tadej; Amon, Mojca; Keramidas, Michail E.; Kounalakis, Stylianos N.

doi:10.3357/asem.3332.2012

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…Nevertheless, in the design of the present study, we considered the characteristics of IH protocols (in relation to the combination of exposure and training, the training intensity and duration and the total hypoxic dose) and exercise performance in severe hypoxia as reviewed by Muza et al in 2007 (28) and investigated in later studies (e.g. (6,7,9,10,24)). In the initial IH sessions of the present study, there was an anticipated and pronounced arterial hypoxemia at rest (S p O 2 < 80%), which improved in the last two sessions (~…”

Section: The Ih Protocol and Exercise Tolerance In Severe Hypoxiamentioning

confidence: 99%

Exercise-induced Fatigue in Severe Hypoxia after an Intermittent Hypoxic Protocol

Twomey¹,

Wrightson

Fletcher

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: The Ih Protocol and Exercise Tolerance In Severe Hypoxiamentioning

confidence: 99%

Exercise-induced Fatigue in Severe Hypoxia after an Intermittent Hypoxic Protocol

Twomey¹,

Wrightson

Fletcher

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Repeated short‐duration hypoxic/normoxic exposure has been developed to alleviate the physical and mental stresses induced by long‐term hypoxic exposure. However, the effects of a 3–6‐min hypoxia/normoxia cycle on exercise performance in humans remain controversial (Julian et al ; Hinckson et al ; Bärtsch et al ; Bonetti et al ; Mekjavic et al ). Repeated hypoxic exposure, comprising a slightly longer hypoxia/normoxia cycle, was shown to improve exercise performance in rodents.…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice

Suzuki

2019

Physiol Rep

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The author previously reported that short‐duration intermittent hypoxia had additive effects on improvements in endurance capacity by enhancing fatty acid metabolism. The present study was designed to investigate the effects of short‐duration intermittent hypoxia on endurance capacity, metabolic enzyme activity, and protein levels associated with mitochondrial biogenesis in well‐trained mice. Mice in the training group were housed in a cage with a running wheel for 7 weeks from 5 weeks old. Voluntary running markedly increased maximal work values by 5.0‐fold. Trained mice were then subjected to either endurance treadmill training (ET) for 60 min or hybrid training (HT, ET for 30 min followed by sprint interval exercise (5‐sec run‐10‐sec rest) for 30 min) with (H‐ET or H‐HT) or without (ET or HT) short‐duration intermittent hypoxia (4 cycles of 12–13% O 2 for 15 min and 20.9% O 2 for 10 min) for 4 weeks. Maximal endurance capacity was markedly greater in the H‐ET and H‐HT than ET and HT groups, respectively. H‐ET and H‐HT increased activity levels of 3‐hydroxyacyl‐CoA‐dehydrogenase in oxidative muscle portion and pyruvate dehydrogenase complex in glycolytic muscle portion. These activity levels were significantly correlated with maximal endurance capacity. Protein levels of dynamin‐related protein‐1 were increased more by H‐ET and H‐HT than by ET and HT, but were not significantly correlated with maximal work. These results suggest that intermittent hypoxic exposure has beneficial effects on endurance and hybrid training to improve the endurance capacity via improving fatty acid and pyruvate oxidation in highly trained mice.

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“…Intermittent hypoxic training (IHT) has become a very popular method nowadays, enhancing exercise performance, working ability or as a pre-acclimatization alpine technique [1]. It refers to the discontinuous use of normobaric or hypobaric hypoxia, in an attempt to reproduce some of the key features of altitude acclimatization [2].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the acute impact of normobaric hypoxia as a part of an intermittent hypoxic training on heart rate variability

Taralov¹,

Terziyski²,

Dimov³

et al. 2015

Cor Vasa

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Zjistit dynamiku autonomního nervového systému (ANS) pomocí variability srdeční frekvence (heart rate variability, HRV) během akutní expozice normobarické hypoxii a po ní, k níž dochází během jednoho sezení podle protokolu intermitentního hypoxického tréninku. Materiál a metody: Čtyřiadvacet zdravých mužů ve věku 28,0 ± 7,2 (průměr ± SD) vdechovalo po dobu jedné hodiny hypoxický vzduch (inspirační koncentrace kyslíku [FiO 2 ] 12,3 ± 1,5 %) z hypoxického generátoru (Al-tiPro 8850 Summit+, Altitude Tech, Kanada). Před expozicí hypoxii, během ní a po ní se provádělo vyšetření pulsní oxymetrií a měřila se variabilita HRV. Výsledky: Na konci hypoxického sezení vykazovali všichni hodnocení jedinci vyšší nízkou frekvenci (lnLF) (6,9 ± 1,1 ms² vs. 7,5 ± 1,1 ms²; p = 0,042), LF/HF (1,5 ± 0,8 vs. 3,3 ± 2,8; p = 0,007) a směrodatnou odchylku 2 na Poincarého mapě (SD2) (92,8 ± 140,0 ms vs. 120,2 ± 54,2 ms; p = 0,005) i nárůst celkové síly (7,7 ± 1,1 ms² vs. 8,1 ± 1,2 ms²; p = 0,032) a směrodatné odchylky intervalu mezi dvěma normálními tepy (SDNN) (57,3 ± 31,0 ms vs. 72,3 ± 41,1 ms; p = 0,024), avšak nižší entropii vzorku (SampEn) (1,6 ± 0,2 vs. 1,4 ± 0,2; p = 0,010). Bezprostředně po expozici hypoxii se snížila hodnota LF/HF (3,3 ± 2,8 vs. 2,2 ± 1,8; p = 0,001) při současném významném zvýšení lnHF (6,6 ± 1,4 ms² vs. 7,1 ± 1,3 ms²; p = 0,020). Závěr: Akutní normobarická hypoxie jako součást jednoho sezení v rámci tréninkového protokolu intermitentní hypoxie vede ke změnám aktivity ANS. Během expozice hypoxii převažuje tonus sympatiku a okamžitě po zrušení účinku hypoxií indukovaného faktoru dochází k nárůstu tonu parasympatiku.

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Intermittent Normobaric Hypoxic Exposures at Rest: Effects on Performance in Normoxia and Hypoxia

Abstract: Based on the results of this study, the IHE does not seem to be beneficial for normoxic and hypoxic performance enhancement.

Cited by 13 publications

References 33 publications

Exercise-induced Fatigue in Severe Hypoxia after an Intermittent Hypoxic Protocol

Exercise-induced Fatigue in Severe Hypoxia after an Intermittent Hypoxic Protocol

Effects of exercise training with short‐duration intermittent hypoxia on endurance performance and muscle metabolism in well‐trained mice

Assessment of the acute impact of normobaric hypoxia as a part of an intermittent hypoxic training on heart rate variability

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