Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone

Yoshioka, Y.; Yamachika, Eiki; Nakanishi, Makoto; Ninomiya, Tadashi; Akashi, Sho; Kondo, Sei; Moritani, Norifumi; Kobayashi, Yasuhiro; Fujii, Toru; Iida, Seiji

doi:10.1038/s41598-019-44389-8

Cited by 6 publications

(6 citation statements)

References 34 publications

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“…network that is important for handling mechanical loads such as masticatory and parafunctional loads around implants. Conversely, it was recently reported that intermittent human PTH(1e34) administration worsened bone quality as assessed by collagen integrity in mandibular regenerative bone but not in long bones [42]. Therefore, caution is required in interpreting our results that intermittent injection of PTH improves bone quality based on collagen and bone cells.…”

Section: Discussioncontrasting

confidence: 56%

Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae

Uchida

Kuroshima

Uto

et al. 2020

Journal of Oral Biosciences

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Objectives: Intermittent injection of parathyroid hormone (PTH) is used to treat osteoporosis. The concept of bone quality was updated 20 years ago; however, these updates have not been adopted in implant dentistry. This study aimed to investigate the effects of intermittent administration of PTH on bone quality around implants in rat tibiae. Methods: Grade IV-titanium-threaded implants that were 3.5 mm long and 2.0 mm wide were placed in a randomly selected side of the proximal tibiae of 12-week-old female Wistar rats. Three weeks after implant placement, the rats were randomly divided into PTH-administration and saline-injection groups (PTH and VC, respectively; n ¼ 7 per group). Micro-computed tomographical, histomorphometric, and immunohistochemical analyses were performed to evaluate bone quality and quantity surrounding the implants. Results: PTH significantly increased bone volume and bone mineral density in bones not associated with the implants as compared to these values in the VC group. PTH significantly increased bone area and the amount of collagen within the total inside areas of all implant threads compared to that observed in VC. Moreover, PTH significantly increased the number of osteoblasts, osteocytes, and osteoclasts in the total inside and/or outside areas of all implant threads and altered the ratio of type I and III collagen to total collagen fibers. Conclusions: Within the limitations of this study, intermittent administration of PTH improved both bone quantity and bone quality based on the types and numbers of bone cells and the types of collagen fibers surrounding implants placed into rat tibiae.

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Section: Discussioncontrasting

confidence: 56%

Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae

Uchida

Kuroshima

Uto

et al. 2020

Journal of Oral Biosciences

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“…The 1–34 amino acid fragment of PTH, i.e., PTH(1–34), is the active sequence responsible for the bone remodeling function of PTH and has been approved for use in the clinical treatment of osteoporosis or as a topical drug in the treatment of bone defects [ 24 ]. Low-dose and intermittent administration of PTH(1–34) leads to anabolic effects in bone regeneration and improvement of bone mineral density [ [25] , [26] , [27] ]. Recently, growing studies have demonstrated that systemic used or local delivery of PTH(1–34) to promote bone regeneration in bone defects [ [28] , [29] , [30] ].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous incorporation of PTH(1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

Zou

Wang

Zhou

et al. 2021

Bioactive Materials

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Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related diseases. Here, we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone (PTH) peptide PTH(1–34) and nano-hydroxyapatite (nHAP). A combination of the positively charged natural polymer chitosan (CS) and negatively charged sodium alginate led to the formation of hydrogels with porous structures, as shown by scanning electron microscopy. Rheological characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1–34). In vitro experiments showed that the hydrogel containing nHAP and PTH(1–34) exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) via the Notch signaling pathway, as shown by the upregulated expression of osteogenic-related proteins. We found that increasing the content of PTH(1–34) in the hydrogels resulted in enhanced osteogenic differentiation of BMSCs. Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP, indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process. Both the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration, suggesting a new strategy for tissue engineering and regeneration in the future.

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“…U slučaju visokih nivoa PTH, povećanje osteoklastne aktivnosti 13 dovodi do poremećaja ravnoteže sistema u pravcu resorpciji kostiju. Osim toga, visoki nivoi PTH mogu smanjiti mineralizaciju i pogoršati kvalitet minerala i kolagena u novoformiranoj kosti 14 . Dakle, ako kortikalna kost gubi debljinu usled bolesti i trabekularna kost se formira slabije mineralizovana, onda to može ugroziti osteointegraciju potpornog implantata.…”

Section: Discussionunclassified

“…In the case of high PTH levels, an increase in osteoclastic activity 13 unbalances the system towards bone resorption. In addition, high PTH levels can reduce mineralization and worsen mineral and collagen quality in a newly formed bone 14 . Therefore, if the cortical bone is losing thickness because of the disease and trabecular bone is formed preferentially but not being substantially mineralized, then supportive implant osseointegration may be compromised.…”

Section: Discussionmentioning

confidence: 99%

Possible effects of hyperparathyroidism in the loss of osseointegration of dental implants: A case report

Petroni¹,

Brodocz²,

Passarett³

et al. 2022

Acta stomatologica Naissi

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Background: Hyperparathyroidism (HPT) is a common endocrine disorder with potential complications on the skeletal, renal, neurocognitive and cardiovascular systems. Its association with the lack of osseointegration of dental implants has not been described in the medical literature. Case presentation: This case report aims to discuss two cases of dental implant loss in which a high level of parathormone (PTH) was found in the absence of any other systemic or local comorbidity, suggesting the possible correlation between HPT and implant. Both patients were referred to the clinic complaining about prosthetic complications, gingival inflammation and mobility of the dental prosthesis. After a Cone-Beam computed Tomography evaluation, all implants of both patients were removed for rejection arising from periimplantitis and then four implants were inserted in the patient 1 and five implants in the patient 2. For both patients short implants (Bicon LLC, Boston, Massachusetts, USA), featured by 4 mm in diameter and 5 mm in height, were used and the prosthesis substructure was made of Trinia® (Bicon LLC, Boston, Massachusetts, USA). During the fifth year, the patients reported complications and the implant treatment failure. In order to establish the causes of failure, a thorough investigation was performed. Since no causes were detected, the patients were required to perform a blood test to evaluate bone metabolism and specifically to assess parathyroid-hormone levels (PTH), calcium levels and vitamin D. Results: The results of the blood tests showed normal calcemia, vitamin D deficiency and elevated PTH levels in both patients. After an endocrinologist's consultation, secondary hyperparathyroidism was diagnosed. Conclusion: It is reasonable to assume that the loss of osseointegration of dental implants can be correlated with the effects of HPT.

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Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone

Cited by 6 publications

References 34 publications

Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae

Intermittent administration of parathyroid hormone improves bone quality and quantity around implants in rat tibiae

Simultaneous incorporation of PTH(1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

Possible effects of hyperparathyroidism in the loss of osseointegration of dental implants: A case report

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