Intermittent phototherapy versus continuous phototherapy for neonatal jaundice

Onyango, Awuonda B B; Suresh, Gautham; Were, Fred

doi:10.1002/14651858.cd008168

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…2 Around 97% of preterm neonates exhibit biochemical hyperbilirubinemia in terms of serum bilirubin above 1 mg/dl while approximately 65% of preterm neonates are estimated to have clinical jaundice. 3 Neonatal jaundice is considered to the most frequent reason for hospitalization among neonates. 4 The "American Academy of Paediatrics (AAP)", stated that neonates who are discharged with 48 hours need to be called for follow ups after 48-72 hours for the evaluation of jaundice and other related issues.…”

Section: Introductionmentioning

confidence: 99%

Intermittent versus continuous phototherapy among term infants presenting with non-hemolytic moderate hyperbilirubinemia at a tertiary care hospital: a randomized controlled trial.

Ahmad¹,

Anwar

Hussain³

et al. 2023

TPMJ

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Objective: To compare the effectiveness of intermittent versus continuous phototherapy among term infants presenting with non-hemolytic moderate hyperbilirubinemia at a tertiary care hospital. Study Design: Single Center, Open Label, Prospective Randomized Controlled Trial. Setting: Department of Neonatology, Sir Sadiq Abbasi Hospital, Bahawalpur, Pakistan. Period: January 2022 to December 2022. Material & Methods: A total of 38 neonates having maternal age between 18-35 years and gestational age at the time birth above or equal to 37 weeks presenting and admitted with non-haemolytic hyperbilirubinemia were included. These neonates (19 in each group) were randomized adopting lottery method to either continuous phototherapy group (CPT) or intermittent phototherapy group (IPT). At the time of enrollment, demographic characteristics like age (days), gender, birth weight (kg), mode of delivery, gestational age (weeks), maternal age (years), total serum bilirubin (mg/dl) in the neonates were noted. Total serum bilirubin levels were recorded after 24 hours of phototherapy. Results: In a total of 38 neonates, 20 (52.6%) were boys. The mean age was calculated to be 3.3±1.8 days. Mode of delivery was cesarean section in 24 (63.2%) neonates. The mean total serum bilirubin levels at baseline was recorded to be 15.5±1.7 mg/dl while comparison of baseline total serum bilirubin levels were not statistically significant different between both study groups (p=0.3715). The mean serum bilirubin levels after 24-hours were recorded to be 11.3±0.9 mg/dl in CPT group versus 11.0±1.1 mg/dl while the difference was noted to be statistically insignificant. (p=0.3637). Conclusion: The intermittent phototherapy yielded relatively similar reduction in total serum bilirubin when compared to continuous phototherapy among neonates with non-haemolytic moderate hyperbilirubinemia.

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Section: Introductionmentioning

confidence: 99%

Intermittent versus continuous phototherapy among term infants presenting with non-hemolytic moderate hyperbilirubinemia at a tertiary care hospital: a randomized controlled trial.

Ahmad¹,

Anwar

Hussain³

et al. 2023

TPMJ

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“…1 About 97% of full term and preterm neonates demonstrate a biochemical hyperbilirubinemia (serum bilirubin > 1 mg/dl) and about 65% appear clinically jaundiced. 2 It is the commonest cause of readmission during early neonatal period. American Academy of Paediatrics recommends that neonates discharged within 48 hours should have a follow-up visit after 48 to 72 hours for any significant jaundice and other problems.…”

Section: Introductionmentioning

confidence: 99%

Continuous vs Intermittent Phototherapy in the Management of Non-Haemolytic Neonatal Hyperbilirubinemia - A Randomised Non - Inferiority Study

Patil

Gowthami

Bijapure

et al. 2020

J. Nepal Paedtr. Soc.

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Introduction: Phototherapy is used to manage neonatal hyperbilirubinemia in early life. We aimed to compare between intermittent and continuous phototherapy in reducing TSB, rate of fall of bilirubin, duration of phototherapy and duration of hospitalisation in neonates with non-haemolytic hyperbilirubinemia. Methods: Total 190 neonates who were > 34 weeks and birth weight ≥ 2000 gm were included. They were randomised into group A (continuous phototherapy) and group B (intermittent phototherapy). Group A received phototherapy for three hours and 45 minutes off and group B received phototherapy for three hours and then three hours off. TSB levels estimation were done in both groups and compared after each 12 hours, 24 hours, and 48 hours of commencing phototherapy. Results: The mean TSB at presentation was 15.64 ± 2.19 mg/dl for continuous and 15.03 ± 1.07 mg/dl for intermittent group. Mean TSB at 12, 24, 48 hours were 13.26 ± 2.4 mg/dl, 10.8 ± 1.72 mg/dl, 10.16 ± 0.95 mg/dl respectively for continuous and 12.6 ± 1.65 mg/dl, 10.04 ±1.8 mg/dl, 9.1 ± 0.66 mg/dl respectively for intermittent group (p < 0.05). The mean rate of fall in serum bilirubin was 0.22 ± 0.12 mg/dl/hr for group A and 0.21 ± 0.08 mg/dl/hr for group B (p = 0.45). There was not much difference in mean duration of hospitalisation in both groups (p = 0.547). Conclusions: Intermittent phototherapy is a non-inferior option to continuous phototherapy, in the management of non-haemolytic hyperbilirubinemia with additional advantages of less interrupted mother infant bonding and decreased irradiance.

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