Intermittent Reperfusion Extends Myocardial Preservation for Transplantation

Beeman, S.; Shuman, Todd A.; Perna, A. M.; Atkinson, James B.; Hammon, John W.; Bender, Harvey W.; Merrill, Walter H.

doi:10.1016/s0003-4975(10)60193-2

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…The end result may be variable perfusion gradient in the myocardium from left ventricle (LV) distention from increased subendocardial wall pressure similar to dilated cardiomyopathy. Intermittent cardioplegic administration is one method proposed to provide a physiologic flow pattern to the donor heart facilitating valve closure (48).…”

Section: Donor Heart Perfusionmentioning

confidence: 99%

Perfusion Preservation of the Donor Heart: Basic Science to Pre-Clinical

Rivard¹,

Gallegos²,

Ogden³

et al. 2009

J Extra Corpor Technol

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As a consequence of technology improvements and refinement, perfusion of the donor heart has moved from the research laboratory to clinical studies. Multiple investigators are currently leading pre-clinical trials of devices using perfusion preservation, and one device is now in European clinical trials. One major problem with the donor heart is the high metabolism relative to other organs, and depletion of ATP leads rapidly to acidosis and necrosis of the myocardium. Two techniques in development to address the issue are normothermic and hypothermic perfusion. This review examines the current issues regarding donor heart preservation and techniques of pre-clinical evaluation necessary for regulatory approval.

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Section: Donor Heart Perfusionmentioning

confidence: 99%

Perfusion Preservation of the Donor Heart: Basic Science to Pre-Clinical

Rivard¹,

Gallegos²,

Ogden³

et al. 2009

J Extra Corpor Technol

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31P-NMR study of cardiac preservation: St. Thomas' Hospital cardioplegic solution versus UW preservation solution

et al. 1991

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Ex vivo cardiac preservation was evaluated by measuring the catabolism of high-energy phosphate (ATP and creatine phosphate, CrP) using 31P-NMR spectroscopy. After cardioplegic arrest St. Thomas' Hospital cardioplegic solution (group A), and University of Wisconsin (UW) preservation solution (group B) were tested. The hearts were mounted in the 4.7 T horizontal bore magnet of the NMR spectrometer and were continuously perfused with the test solution under 25 cm H2O pressure for 6 h at 10 degrees C. Peak heights of the beta-phosphate of ATP and CrP were measured and expressed as percentages of the initial value. For both group A and group B. ATP declined less rapidly during preservation than CrP. In group A, ATP remained constant for 60 min while CrP decreased from the onset of preservation. After 6 h of preservation 28.3% of ATP and 24.5% of CrP remained (group A). On the other hand, in group B, levels of both ATP and CrP remained much more stable: CrP did not decrease during the first 3 h of preservation, while ATP started to decrease after 5 h. At the end of preservation 76.1% of ATP and 71.5% of CrP were still present. We conclude that UW solution is superior to St. Thomas' Hospital solution for the preservation of high-energy phosphates during 6 h cardiac preservation with continuous hypothermic low-flow perfusion.

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Hypothermic preservation of the rat heart

Larese

Aussedat

et al. 1990

Cryobiology

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Intermittent Reperfusion Extends Myocardial Preservation for Transplantation

Cited by 6 publications

References 13 publications

Perfusion Preservation of the Donor Heart: Basic Science to Pre-Clinical

Perfusion Preservation of the Donor Heart: Basic Science to Pre-Clinical

31P-NMR study of cardiac preservation: St. Thomas' Hospital cardioplegic solution versus UW preservation solution

Hypothermic preservation of the rat heart

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