Intermittent short course therapy for pediatric tuberculosis

Indumathi, C K; Prasanna, K. Kumar; Dinakar, Chitra; Shet, Anita; Lewin, Sanjiv

doi:10.1007/s13312-010-0012-7

Cited by 9 publications

(10 citation statements)

References 9 publications

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“…The treatment outcome in paediatric TB is gauged according to the clinical parameters which are different than the adult counterparts. Most of the patients were female similar to studies done by Sharma S et al, 8 C K Indumathi et al 9 The high prevalence of cases in females in our study could be explained by the fact that most of our study population belonged to lower socioeconomic class where the females exposed to the infection are more prone to develop the disease due to either poor nutritional status or poor immunity. The poor BCG vaccination status in females might also be a responsible factor for acquiring the infection.…”

Section: Discussionsupporting

confidence: 89%

“…(Table 1). In the present study, mean age of presentation (6.9 years, SD = 3.7) is younger than other studies in tertiary care institutes (CK Indumathi et al, 9 Shivanandan S et al, 10 Shrestha S et al 11 ), may be because of more number of malnourished children in this study who might have presented earlier in the disease process. The nutrition has significant impact on the outcome of TB.…”

Section: Discussioncontrasting

confidence: 65%

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Effectiveness of Dots Therapy Under RNTCP-Dots Strategy in Paediatric Tbexperience From Western India

Kadam¹,

Wagh²,

Rajput³

et al. 2017

jemds

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BACKGROUNDThough estimated one million new cases of tuberculosis occur in children worldwide each year, paediatric TB has not been given the same priority as its adult counterpart. TB in children needs to be identified promptly and managed effectively. The DOTS strategy appears to be highly effective for paediatric TB, as reported by studies from all over the world. The aim of this study is to evaluate the efficacy of the DOTS strategy in the management of paediatric TB patients and factors affecting the outcome of paediatric TB patients.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 65%

Effectiveness of Dots Therapy Under RNTCP-Dots Strategy in Paediatric Tbexperience From Western India

Kadam¹,

Wagh²,

Rajput³

et al. 2017

jemds

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“…In other studies, the completion/ cure rates varied from 80% to 94.9% as shown in Table 2. 4,7,15,16 Higher treatment completion rates in the present study was due to strict adherence to DOTS strategy under RNTCP, the medicines were available without break and good compliance of the patients. There were no adverse effects due to anti-tubercular drugs in the present study.…”

Section: Discussionmentioning

confidence: 70%

“…[6][7][8] Only 30 cases (33%) belonged to the below 5 years age group. Other studies have reported maximum number of patients in 1-5 years age group.…”

Section: Discussionmentioning

confidence: 99%

Profile and outcome of childhood tuberculosis treated with DOTS at a tertiary care hospital in central India: an observational study

Bharani

Harshey

Raipurkar

2018

Int J Contemp Pediatr

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Background: Children contribute a significant proportion of the tuberculosis (TB) burden in India and suffer severe TB related morbidity and mortality, particularly in endemic areas. Diagnosis and management of pediatric TB especially Extra pulmonary (EPTB) is challenging. The present study was designed to study clinical, laboratory characteristics and outcome of childhood tuberculosis.Methods: A retrospective analysis of 90 cases of TB in children within 2 year period was conducted at Pediatric Department and DOTS center at a tertiary care hospital from January 2015 to December 2016.Results: In the present study 20% of the total TB patients attending DOTS OPD were Children. Most common symptoms were Fever (53.3 %), Cough (46.6%), abdominal pain (18.8%), lymphadenopathy (13.3%), osteo-articular symptoms (13.3%), weight loss (10%), CNS related complaints like convulsions and unconsciousness (6.6%). History of contact was present in 10 cases (11%). Sputum examination was positive in 9 cases (10%) who were predominantly older children above 12 years. Mantoux test was positive in 9 cases (10%). Only one patient was HIV positive. Extra pulmonary tuberculosis (EPTB) patients were more common than pulmonary. 47 out of the 90 cases (52%) were receiving DOTS for EPTB. Out of the 90 cases 84 (93.3%) were on New Category 1 treatment and 6 (6.6%) were on Cat 2 treatment. Out of the total 90 cases 3 defaulted, 3 died, rest completed treatment with good compliance and no side-effects and were declared cured.Conclusions: In present study, it was found that extra-pulmonary tuberculosis (EPTB) patients are more common than pulmonary tuberculosis in pediatric age group. Sputum positivity yield is very low in pediatric age group. Success of treatment with DOTS is good (94.4%). No adverse effects of ATT were observed.

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“…No relapse occurred in the patients who received 6-month intermittent therapy, although there were four relapses in the 9-month group. (20). The overall cure rate was 95%, and radiological response was noted in 90% of children.…”

mentioning

confidence: 89%

Unfinished battle with childhood tuberculosis: is it curable with less drugs and shorter duration?

Cinel

Ki̇per²,

Pekcan³

et al. 2013

Tuberk Toraks

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ÖZET Çocukluk çağı tüberkülozu ile bitmeyen savaş: Daha az ilaç ve daha kısa sürede tedavi edilebilir mi?Giriş: Etkili tedavi rejimleriyle mortalitesi tüm dünyada azalmış olsa da tüberküloz halen global bir sağlık problemidir. Tedaviye uyumsuzluk, ilaç direnci, tedavi INTRODUCTIONTuberculosis (TB), which was responsible for millions of deaths in the epidemics between 17 th and 19 th century, is the leading cause of death associated with infectious diseases globally (1). Although its mortality has been decreased with effective treatment regimens, TB is still a global health problem all over the world. An estimated one-third of the world's population is infected with TB (2). TB accounted for 1.3 million deaths in Cinel G, Kiper N, Pekcan S, Koyun M, Köse M, Çobanoğlu N, Tana Aslan A, Yalçın E, Doğru D, Özçelik U, Göçmen A. 321Tuberk Toraks 2013; 61(4): 320-326

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Intermittent short course therapy for pediatric tuberculosis

Cited by 9 publications

References 9 publications

Effectiveness of Dots Therapy Under RNTCP-Dots Strategy in Paediatric Tbexperience From Western India

Effectiveness of Dots Therapy Under RNTCP-Dots Strategy in Paediatric Tbexperience From Western India

Profile and outcome of childhood tuberculosis treated with DOTS at a tertiary care hospital in central India: an observational study

Unfinished battle with childhood tuberculosis: is it curable with less drugs and shorter duration?

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