Intermolecular C–H Aminocyanation of Indoles via Copper–iodine Cocatalyzed Tandem C–N/C–C Bond Formation

Yu, Wenhua; Zhang, Xiaoxiang; Liu, Chenrui; Zhang, Yingying; Liao, Jiahao; Zhang, Zhuan; Wei, Wanxing; Li, Guanghua; Liang, Taoyuan

doi:10.1021/acs.joc.2c01703

Cited by 15 publications

(2 citation statements)

References 59 publications

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“…[ 37,38 ] Therefore, the chemical compositions of these membrane surfaces are listed in Table 2, where N elements increased gradually with the PPTA content increasing in the substrates, while the O/N ratio decreased from 1.66 to 1.38, indicating a gradual increase in crosslinking density. [ 39–41 ] This trend might be advantageous to maintain the excellent salt rejection, and the reason for this phenomenon maybe mainly explained that more mPD stored on the substrate surface diffused to react with TMC because of the strong affinity between the mPD and PPTA exposed on the substrate. However, higher crosslinking density of the polyamide functional layer meant higher rejection and lower permeation because the main filtration resistance came from the polyamide layer.…”

Section: Resultsmentioning

confidence: 99%

Enhancing the permeability of reverse osmosis membrane by embedding the star‐like rigid supports in the substrate

Lian

Liu

Xie

et al. 2020

J of Applied Polymer Sci

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Thin film composite (TFC) reverse osmosis (RO) membranes with high permeability have been prepared by interfacial polymerization based on tailoring the polysulfone (PSf) substrate structure by in situ embedded poly(p‐phenylene terephthamide) (PPTA) star‐like rigid supports. The star‐like rigid supports were observed by the polarizing optical microscopy (POM) and transmission electron microscope (TEM). The surface properties of the substrates were investigated by FTIR, the water contact angle (WCA), FESEM and AFM. The WCA was decreased from 88.5° to 72.3° with the PPTA increasing from 0% to 8%, and the surface roughness increased from 24.2, 25.1, 33.5 and 58.6 nm, respectively. Furthermore, numerous interconnect micro‐structures were constructed in the substrate when the PPTA content was up to 8%. The pure water flux of 8% PPTA/92%PSf substrate was up to 377.0 L m−2 h−1 and the flux decline rate was lowest (64%) after compacted at 5.5 MPa for 30 min. Otherwise, increasing the PPTA contents in the substrate enhanced the roughness, encouraged nanosheet formation and improved the permeability of TFC RO membranes. The pure water flux of the TFC RO membranes increased from 36.32 to 58.42 L m−2 h−1, where the NaCl rejection was about 99.5% at 5.5 MPa.

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Section: Resultsmentioning

confidence: 99%

Enhancing the permeability of reverse osmosis membrane by embedding the star‐like rigid supports in the substrate

Lian

Liu

Xie

et al. 2020

J of Applied Polymer Sci

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“…As part of our continuous efforts to develop innovative methods for the synthesis and functionalization of indoles, [ 11 ] we present our unexpected findings on a one‐step, three‐component intermolecular C—H diamination reaction for the highly regioselective synthesis of 2,3‐diaminoindole. This reaction utilizes a copper‐iodine co‐catalytic system (Scheme 1b).…”

Section: Background and Originality Contentmentioning

confidence: 99%

Synthesis of 2,3‐Diaminoindolesvia a Copper‐Iodine Co‐catalytic Strategy

Yu,

Zhang,

Zhang

et al. 2023

Chin. J. Chem.

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Comprehensive SummaryA one‐pot synthesis of vicinal diamines using indoles, azoles and phenothiazines in a tandem multi‐component reaction is developed. The utilization of a copper‐iodine co‐catalytic system enables the generation of a diverse range of vicinal diaminoindoles with good selectivity and moderate to good yields. An attractive aspect of this method is that it can be conducted under mild and environmentally friendly conditions, showcasing its potential as an alternative approach for synthesizing vicinal diamines. Moreover, the use of a multicomponent tandem reaction highlights the power and versatility of such strategies in synthetic chemistry.

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Multicomponent Tandem Triple Functionalization of Indoles via a Directing‐group‐free Strategy

Zhang

Sun

et al. 2023

Adv Synth Catal

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The position-selective functionalization of the poorly reactive benzenoid nucleus of indoles has remained a great challenge in organic chemistry.Here we describe a directing-group-free, threecomponent tandem C3-acylation/C5,6-H disulfenylation of indoles via an iodine-, Lewis acid-and Brønsted acid-cooperated mediated strategy. This protocol is remarkable for its exceptional regio-and chemo-selectivity, broad substrate scope, good functional group tolerance and mild reaction conditions. Advantageously, the present protocol offers great potential for the development of general siteselective functionalization at the benzenoid nucleus of indoles, removing the requirement for neighbouring activating groups.

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Intermolecular C–H Aminocyanation of Indoles via Copper–iodine Cocatalyzed Tandem C–N/C–C Bond Formation

Cited by 15 publications

References 59 publications

Enhancing the permeability of reverse osmosis membrane by embedding the star‐like rigid supports in the substrate

Enhancing the permeability of reverse osmosis membrane by embedding the star‐like rigid supports in the substrate

Synthesis of 2,3‐Diaminoindolesvia a Copper‐Iodine Co‐catalytic Strategy

Multicomponent Tandem Triple Functionalization of Indoles via a Directing‐group‐free Strategy

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