Intermolecular degradation of aromatic compound and its derivatives via combined sequential and hybridized process

Chromatographic Separation of Aromatic Amine Isomers: A Solved Issue by a New Amphiphilic Pillar[6]arene Stationary Phase

“…Aromatic amines are extensively used as raw materials or as intermediates in the manufacturing of industrial chemicals such as pharmaceuticals, agrochemicals, polymers, azo dyes, and rubbers. − Aromatic anilines are classified as an important class of environmental pollutants because they are highly toxic to humans and are potential carcinogens. − Due to their high solubility in water, they are easy to penetrate into soil and pollute groundwater, where they have been found at trace levels (<10 μg/L). − For this reason, in this last period, an increasing attention has been devoted to the development of new, reliable, highly selective, sensitive, and rapid analytical methods for their detection, leading to the publication of numerous reports in this field, − exploiting in particular gas chromatography (GC) techniques. − However, direct determination of aromatic aniline isomers using GC techniques is still difficult due to their polar nature; then, aromatic aniline isomers are usually first derivatized and then determined by GC in combination with mass spectrometry (MS) techniques. − Derivatization greatly increases the analysis time and its cost, and it makes use of great amounts of organic solvents, becoming a source of environmental pollution.…”