1994
DOI: 10.1021/ja00097a025
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Intermolecular Effects in Crystals of 11-(Trifluoromethyl)-15,16-dihydrocyclopenta[a]phenanthren-17-one

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Cited by 97 publications
(46 citation statements)
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“…Halothane has the potential to act as a hydrogen bond acceptor via one or more of its halogen atoms (53)(54)(55), which may interact favorably with either indole ring hydrogens or with the cysteine sulfhydryl group. While the detailed structure of the complex formed between halothane and (AR 2 ) 2 remains to be determined, it is clear that the anesthetic resides in the vicinity of the hydrophobic core tryptophan residues as designed, since fluorescence quenching by heavy atoms is a short-range phenomenon occurring over a distances less than 3-5 Å (56,57).…”
Section: Discussionmentioning
confidence: 99%
“…Halothane has the potential to act as a hydrogen bond acceptor via one or more of its halogen atoms (53)(54)(55), which may interact favorably with either indole ring hydrogens or with the cysteine sulfhydryl group. While the detailed structure of the complex formed between halothane and (AR 2 ) 2 remains to be determined, it is clear that the anesthetic resides in the vicinity of the hydrophobic core tryptophan residues as designed, since fluorescence quenching by heavy atoms is a short-range phenomenon occurring over a distances less than 3-5 Å (56,57).…”
Section: Discussionmentioning
confidence: 99%
“…In this case intramolecular strains caused by repulsion between protons in pseudo fjord-region are balanced by shortening some bonds which acquire more double bond character and by enlarging exocyclic angles within pseudo fjord-region (Table 2). It should be noted that these angles and bond lengths were comparable to those in bay-region of muta-and carcinogenic cyclopenta[a]phenanthrene derivatives (27). For example: 1,11-methano-15,16-dihydrocyclopenta[a]phenanthren-17-one which is planar but severing bond angle distortions possess an Iball index = 16 (28).…”
Section: Discussionmentioning
confidence: 55%
“…Standard PCR reaction conditions and thermal cycling protocol were described in the papers cited in Table 1. In order to adopt a more semi-quantitative approach for analysis of the gene expression, both CYP1A and ß-actin gene (external standard) were amplified using a series of cycle numbers (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Following this procedure the optimal cycle number was determined and subsequently employed in the expression studies.…”
Section: Total Rna Isolation and Semi-quantitative Rt-pcrmentioning
confidence: 99%
“…In contrast to anionic fluoride, organic fluorine is a poor hydrogen‐bond acceptor. X‐ray diffraction analyses (Murray‐Rust et al 1983; Shimoni et al 1994) as well as extensive surveys of structural databases (Shimoni and Glusker 1994; Howard et al 1996; Dunitz and Taylor 1997) have revealed but few crystalline organofluorine compounds that display short C–F···H–X distances, where X = C, N, or O. In addition, a presumably intimate C–F···H–N interaction does not stabilize DNA double helices (Moran et al 1997).…”
Section: Resultsmentioning
confidence: 99%