Intermolecular interaction and morphology investigation of drug loaded ABA-triblock copolymers with different hydrophilic/lipophilic ratios

Khoee, Sepideh; Rahimi, Hasan B.

doi:10.1016/j.bmc.2010.08.009

Cited by 9 publications

(3 citation statements)

References 16 publications

(14 reference statements)

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“…46 Also, the open nature of the dendritic architecture and an abundance of functional groups facilitate drug encapsulation into the branches of dendritic parts. 47 In comparison with our previous study, 48 it is concluded that an increase in the number of interactions between drug and the polyester play an important role to have appropriate drug loading. Moreover, according to another study of our research group, 35 the Brunauer−Emmet−Teller (BET) adsorption data revealed that the N 2 adsorption/desorption amount of dendritic structure is higher than that of linear structure.…”

Section: Resultsmentioning

confidence: 69%

Preparation and Evaluation of Contact Lenses Embedded with Polycaprolactone-Based Nanoparticles for Ocular Drug Delivery

et al. 2016

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To improve the efficiency of topical ocular drug administration, we focused on development of a nanoparticles loaded contact lens to deliver the hydrophobic drug over a prolonged period of time. The cross-linked nanoparticles based on PCL (poly ε-caprolactone), 2-hydroxy ethyl methacrylate (HEMA), and poly ethylene glycol diacrylate (PEG-DA) were prepared by surfactant-free miniemulsion polymerization. The lens material was prepared through photopolymerization of HEMA and N-vinylpyrrolidone (NVP) using PEG-DA as the cross-linker. Effects of nanoparticles loading on critical contact lens properties such as transparency, water content, modulus and ion and oxygen permeabilities were studied. Nanoparticles and hydrogel showed high viability, indicating the absence of cytotoxicity and stimulatory effect. Drug release studies revealed that the hydrogel embedded with nanoparticles released the drug for a period of 12 days. The results of this study provide evidence that nanoparticles loaded hydrogels could be used for extended delivery of loteprednol etabonate and perhaps other drugs.

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Section: Resultsmentioning

confidence: 69%

Preparation and Evaluation of Contact Lenses Embedded with Polycaprolactone-Based Nanoparticles for Ocular Drug Delivery

et al. 2016

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“…In comparison with previous study [55], it is clearly concluded that increase in the number of interactions between drug and the polyester play an important role to have appropriate drug loading. As a result, the presence of poly(amino-ester) block causes more interactions between the hydroxyl and ester groups of LPE and the functional groups of the polyester in the nanoparticle structure.…”

Section: Drug Loading and Encapsulation Efficiencymentioning

confidence: 78%

Design, characterization and in vitro evaluation of novel shell crosslinked poly(butylene adipate)-co-N-succinyl chitosan nanogels containing loteprednol etabonate: A new system for therapeutic effect enhancement via controlled drug delivery

Nasr

Khoee

2015

European Journal of Medicinal Chemistry

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“…On the basis of these considerations and in continuum to our previous work [24], the main goal of this work was to develop new synthetic route for preparation of PLGA-PEG block copolymer in order to obtain stable nanomicelle with low CMC value. Here, amphiphilic block PLGA-PEG copolymer was strategically designed and synthesized by free radical copolymerization of functionalized macromers; acryloyl-terminated water-insoluble PLGA and acryloylterminated water-soluble PEG.…”

Section: Introductionmentioning

confidence: 98%

Self-assembled nanomicelles using PLGA–PEG amphiphilic block copolymer for insulin delivery: a physicochemical investigation and determination of CMC values

Ashjari

Khoee

Mahdavian

et al. 2012

J Mater Sci: Mater Med

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Self-assembled nanomicelles can be used as synthetic biomaterials and colloidal carriers for poorly water-soluble drug delivery systems. Some of these micellar systems have been introduced in clinical trials and showed hopeful results relating to their therapeutic index in patients. Biodegradable nanomicelle was prepared from self-assembling amphiphilic block copolymer composed of poly(DL-lactic-co-glycolic acid) (PLGA) as a core and polyethylene glycol (PEG) as a corona. The PLGA-PEG block copolymer was first synthesized and characterized by FTIR, (1)H NMR, GPC and inherent viscosity measurements. The nanomicelle formed by PLGA-PEG block copolymer in the aqueous solution was characterized by dynamic light scattering, zeta potential, scanning electron microscopy (SEM) and fluorescence excitation and emission spectra of pyrene probe. The critical micelle concentration of obtained nanomicelle was about 0.006 mg/mL, with the size of about 160 nm and the zeta potential of -29 mV. Insulin-loaded PLGA-PEG nanomicelles were prepared by modified dialysis method and the physicochemical parameters of the micelles such as drug content, entrapment efficiency and in vitro drug release were characterized. The results showed that insulin was entrapped into PLGA-PEG nanomicelles with drug loading of 3.9 wt% and entrapment efficiency of 55 wt%. The nanomicelles containing insulin exhibited a controlled release profile. These observations suggested that the PLGA-PEG block copolymers nanomicelles have been prepared by a new synthetic route are potent nanocarrier for poorly water-soluble drugs as insulin.

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Intermolecular interaction and morphology investigation of drug loaded ABA-triblock copolymers with different hydrophilic/lipophilic ratios

Cited by 9 publications

References 16 publications

Preparation and Evaluation of Contact Lenses Embedded with Polycaprolactone-Based Nanoparticles for Ocular Drug Delivery

Preparation and Evaluation of Contact Lenses Embedded with Polycaprolactone-Based Nanoparticles for Ocular Drug Delivery

Design, characterization and in vitro evaluation of novel shell crosslinked poly(butylene adipate)-co-N-succinyl chitosan nanogels containing loteprednol etabonate: A new system for therapeutic effect enhancement via controlled drug delivery

Self-assembled nanomicelles using PLGA–PEG amphiphilic block copolymer for insulin delivery: a physicochemical investigation and determination of CMC values

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