Intermolecular interactions of lysobisphosphatidic acid with phosphatidylcholine in mixed bilayers

Holopainen, Juha M.; Söderlund, Tim; Alakoskela, Juha-Matti; Säily, Matti; Eriksson, Ove; Kinnunen, Paavo K.J.

doi:10.1016/j.chemphyslip.2004.08.004

Cited by 15 publications

(15 citation statements)

References 50 publications

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“…The mechanism by which BMP induces its differential effect on VSV is presently unclear, but it is likely to be due to an interaction with the viral fusion peptide. BMP is a unique derivative of phosphatidylglycerol that shows unusual features for a membrane phospholipid [29]. One possibility for the effect of BMP is related to its shape; however whether the lipid is a cone, inverted cone or cylindrical in shape is unclear [29].…”

Section: Resultsmentioning

confidence: 99%

“…BMP is a unique derivative of phosphatidylglycerol that shows unusual features for a membrane phospholipid [29]. One possibility for the effect of BMP is related to its shape; however whether the lipid is a cone, inverted cone or cylindrical in shape is unclear [29]. It has previously been reported that influenza virus HA‐mediated fusion was inhibited by the inverted cone‐shaped lipid lysophosphatidic acid and promoted by the cone‐shaped oleic acid [30].…”

Section: Resultsmentioning

confidence: 99%

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Promotion of vesicular stomatitis virus fusion by the endosome-specific phospholipid bis(monoacylglycero)phosphate (BMP)

Roth

Whittaker

2011

FEBS Letters

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Edited by Hans-Dieter Klenk Keywords:Membrane fusion Endosome Lipid VSV Influenza Virus entry a b s t r a c t Vesicular stomatitis virus (VSV) is a prototypic virus commonly used in studies of endocytosis and membrane trafficking. One proposed mechanism for VSV entry involves initial fusion with internal vesicles of multivesicular endosomes followed by back-fusion of these vesicles into the cytoplasm. One feature of endosomal internal vesicles is that they contain the lipid bis(monoacylglycero)phosphate (BMP). Here, we show that the presence of BMP significantly increases the rate of VSV G-mediated membrane fusion. The increased fusion was selective for VSV and was not evident for another enveloped virus, influenza virus. Our data provide a biological rationale for a two-step infection reaction during VSV entry, and suggest that BMP preferentially affects the ability of VSV G to mediate lipid mixing during membrane fusion.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Promotion of vesicular stomatitis virus fusion by the endosome-specific phospholipid bis(monoacylglycero)phosphate (BMP)

Roth

Whittaker

2011

FEBS Letters

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“…Lysobisphosphatidic acid (LBPA), also known as bis(monoacylglycero)phosphate, is a minor lipid (<1% of total lipids) formed from the degradation of phosphatidylglycerol and cardiolipin (40,41). LBPA is found mostly in late endosomes, where it accounts for about 15% of the total lipids (42).…”

Section: Phosphatidylserinementioning

confidence: 99%

Lipid signaling and the modulation of surface charge during phagocytosis

Yeung

Grinstein

2007

Immunological Reviews

158

176

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Phagocytosis is an important component of innate and adaptive immunity. The formation of phagosomes and the subsequent maturation that capacitates them for pathogen elimination and antigen presentation are complex processes that involve signal transduction, cytoskeletal reorganization, and membrane remodeling. Lipids are increasingly appreciated to play a crucial role in these events. Sphingolipids, cholesterol, and glycerophospholipids, notably the phosphoinositides, are required for the segregation of signaling microdomains and for the generation of second messengers. They are also instrumental in the remodeling of the actin cytoskeleton and in directing membrane traffic. They accomplish these feats by congregating into liquid-ordered domains, by generating active metabolites that activate receptors, and by recruiting and anchoring specific protein ligands to the membrane, often altering their conformation and catalytic activity. A less appreciated role of acidic phospholipids is their contribution to the negative surface charge of the inner leaflet of the plasmalemma. The unique negativity of the inner aspect of the plasma membrane serves to attract and anchor key signaling and effector molecules that are required to initiate phagosome formation. Conversely, the loss of charge that accompanies phospholipid metabolism as phagosomes seal facilitates the dissociation of proteins and the termination of signaling and cytoskeleton assembly. In this manner, lipids provide a binary electrostatic switch to control phagocytosis.

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“…11 Since these initial studies, a number of techniques including electron microscopy, differential scanning calorimetry, fluorescence spectroscopy, and small-and wide-angle X-ray scattering have been used to probe membrane structures and phase transitions in different membranes containing BMP. [12][13][14] While these studies have provided insights such as the pH-dependence of membrane morphology in different compositions containing BMP, and the effect of BMP stereochemistry on membrane properties, further analysis is needed to understand how BMP affects membrane structure.…”

Section: Introductionmentioning

confidence: 98%

Modular synthesis of bis(monoacylglycero)phosphate for convenient access to analogues bearing hydrocarbon and perdeuterated acyl chains of varying length

Rowland

Best

2009

Tetrahedron

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Intermolecular interactions of lysobisphosphatidic acid with phosphatidylcholine in mixed bilayers

Cited by 15 publications

References 50 publications

Promotion of vesicular stomatitis virus fusion by the endosome-specific phospholipid bis(monoacylglycero)phosphate (BMP)

Promotion of vesicular stomatitis virus fusion by the endosome-specific phospholipid bis(monoacylglycero)phosphate (BMP)

Lipid signaling and the modulation of surface charge during phagocytosis

Modular synthesis of bis(monoacylglycero)phosphate for convenient access to analogues bearing hydrocarbon and perdeuterated acyl chains of varying length

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