Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults

Kim, Jaehee; Heshka, Stanley; Gallagher, Dympna; Kotler, Donald P.; Mayer, Laurel; Albu, Jeanine; Shen, Wei; Freda, Pamela U.; Heymsfield, Steven B.

doi:10.1152/japplphysiol.00260.2004

Cited by 175 publications

(201 citation statements)

References 21 publications

Supporting

Mentioning

182

Contrasting

Unclassified

Order By: Relevance

“…Our results, therefore, cannot be extrapolated to the frail or institutionalized older adults, in whom sex hormone decline may be disease associated rather than ageassociated, and in whom the relationship of sex hormone with muscle mass, muscle strength and physical performance may be different. The presence of intramuscular adipose tissue renders DXA measurement of muscle mass less accurate when compared with the magnetic resonance imaging method (36). Table 3 Relationship between testosterone level, grip strength and physical performance.…”

Section: Discussionmentioning

confidence: 99%

Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men

Auyeung¹,

Lee²,

Kwok³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To examine the relationship between different measures of testosterone and estradiol (E 2 ), muscle mass, muscle strength, and physical performance; and to test whether the association of sex hormone level with muscle strength and physical performance was independent of muscle mass. Design and methods: A cross-sectional survey on 1489 community-dwelling men older than 64 years of age. Serum levels of testosterone and E 2 were measured by mass spectrometry, and sex hormonebinding globulin (SHBG) levels were measured by immunoradioassay. Muscle mass was examined by dual-energy X-ray absorptiometry and physical performance was assessed by hand-grip strength, gait speed, step length and chair-stand test. Results: Appendicular skeletal mass (ASM) was positively associated with total testosterone (TT; P!0.001), free testosterone (FT; P!0.001), and total E 2 (P!0.001) but not with free E 2 (PZ0.102). After adjustment for age, serum SHBG and relative ASM, both TT and FT were significantly associated with grip strength, narrow-walk speed and the composite neuromuscular score. Higher total E 2 , but not free E 2 was associated with lower grip strength (P!0.05) after adjustment for age, FT, SHBG and relative ASM. Conclusions: Testosterone level was related to both muscle mass, strength and physical performance. Total E 2 level, though related to muscle mass positively, affected muscle strength adversely in older men. European Journal of Endocrinology 164 811-817 IntroductionSeveral studies have examined the inter-relationship between various measures of testosterone level, muscle mass and muscle strength (1-6). In men aged 65 or older, Baumgartner et al.(1) reported that free testosterone index, but not total testosterone (TT) level, was modestly associated with muscle mass, whereas Iannuzzi-Sucich et al. (2) demonstrated that muscle mass was correlated to bioavailable testosterone (BioT), leg strength and physical performance. However, in another cohort of healthy older men, Van den Beld et al. (3) reported that testosterone level, as represented by TT and BioT, was related to muscle strength but not to muscle mass. On the other hand, Roy et al. (5) observed that TT and BioT were positively correlated with both the muscle mass and strength, yet after adjustment for muscle mass, they were no longer independently associated with muscle strength. Szulc et al. (4) had compared the muscle mass and physical performance of hypogonadal and eugonadal men and found that hypogonadal men exhibited impaired static and dynamic balance despite relatively preserved muscle mass. Similarly, Orwoll et al. (6) have observed that testosterone level was related to physical performance and fall risk but not to muscle mass. Although the effect of testosterone supplementation on muscle mass and strength was less controversial in interventional studies (7-14), whether endogenous testosterone was related to muscle mass alone, muscle strength alone, or both; and which measures of endogenous testosterone best related to muscle ...

show abstract

Section: Discussionmentioning

confidence: 99%

Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men

Auyeung¹,

Lee²,

Kwok³

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…for fat mass and LBM were 1.7 and 0.7% respectively. Appendicular skeletal muscle mass (ASMM) was calculated from lean mass in arms and legs obtained from the DXA as previously described (25).…”

Section: Measurementsmentioning

confidence: 99%

Body composition and bone mineral density in women with Cushing's syndrome in remission and the association with common genetic variants influencing glucocorticoid sensitivity

Ragnarsson

Glad

Bergthorsdottir

et al. 2015

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Adverse body compositional features and low bone mineral density (BMD) are the characteristic of patients with active Cushing's syndrome (CS). The aim of this study was to evaluate body composition and BMD in women with CS in long-term remission and the influence of polymorphisms in genes affecting glucocorticoid (GC) sensitivity on these end-points. Design, patients and methods: This was a cross-sectional, case-controlled study, including 50 women previously treated for CS and 50 age and gender-matched controls. Median (interquartile range) remission time was 13 (5-19) years. Body composition and BMD were measured with dual-energy X-ray absorptiometry. Five polymorphisms in four genes associated with GC sensitivity were analysed using TaqMan or Sequenom single-nucleotide polymorphism genotyping. Results: Patients with CS in remission had increased abdominal fat mass (P!0.01), whereas BMD was not significantly different at any site between patients and controls. In patients, the NR3C1 Bcl1 polymorphism was associated with reduced total (P!0.05) and femur neck BMD (P!0.05). The polymorphism rs1045642 in the ABCB1 gene was associated with increased abdominal fat mass (P!0.05) and decreased appendicular skeletal muscle mass (P!0.05). GC replacement was associated with reduced total BMD (P!0.01), BMD at lumbar spine (P!0.05) and increased abdominal fat (P!0.01). Conclusion: Ongoing GC replacement therapy together with polymorphisms in two genes related with GC sensitivity is associated with abdominal obesity and adverse skeletal health in patients with CS in long-term remission.

show abstract

“…Mais recentemente, novas equações antropométricas para a avaliação da MM foram desenvolvidas, contudo, em sua grande maioria, para a utilização com equipamentos de alto custo operacional e com maior tempo despendido para a avaliação (5,(9)(10)(11)(12)(13)(14)(15)(16) , o que as torna pouco utilizadas, especialmente para grandes grupos populacionais.…”

Section: Introductionunclassified

“…Entretanto, considerando que grande parte do tecido magro e mole apendicular (TMMA), ou seja, a massa corporal livre de gordura e de osso de membros superiores e inferiores, é composto por MM, e que grande quantidade da MM do corpo está presente nos membros, a DEXA é considerada um bom instrumento para avaliação da MM em humanos (9) . Com base nas informações apresentadas e na inexistência no Brasil de estudos de validação de equações preditivas para o cálculo da MM, o objetivo deste trabalho foi analisar a validade de equações antropométricas para a estimativa da MM a partir de DEXA, em jovens universitários brasileiros, do sexo masculino.…”

Section: Introductionunclassified

Validação de equações antropométricas para a estimativa da massa muscular por meio de absortometria radiológica de dupla energia em universitários do sexo masculino

Cyrino

Petroski

Cardoso

et al. 2008

Rev Bras Med Esporte

View full text Add to dashboard Cite

Artigo originAl RESUMODiferentes equações antropométricas têm sido desenvolvidas e validadas para uso em populações distintas, a partir de modelos multicompartimentais. A absortometria radiológica de dupla energia (DEXA) é uma alternativa multicompartimental de avaliação da composição corporal, ainda pouco utilizada no Brasil para validação e desenvolvimento de equações antropométricas, sobretudo para predição da massa muscular (MM). Assim, o objetivo deste estudo foi validar equações antropométricas para estimativa da MM a partir da DEXA, em universitários brasileiros do sexo masculino. Para tanto, 131 adultos entre 18 e 36 anos (73,9 ± 9,7kg; 177,6 ± 6,4cm; MM = 32,1 ± 3,6kg) foram avaliados por meio da DEXA e de medidas antropométricas (massa corporal, estatura, circunferências e espessura de dobras cutâneas), e analisados mediante utilização de quatro equações preditivas da MM. Foram utilizadas as seguintes análises: estatística descritiva, procedimentos de validação cruzada e análise de concordância (CCI e Bland e Altman). , erro constante (-0,72), erro total (2,72) e d (-0,77) e boas concordâncias (moderada a alta) foi sugerida para utilização na amostra estudada. Novos estudos de validação são sugeridos em amostras diferentes, mediante o uso de DEXA como método de referência. Da mesma forma, sugere-se maior utilização de equações antropométricas para avaliação da MM, sobretudo para o monitoramento das alterações na massa muscular em relação aos processos de crescimento, desenvolvimento e envelhecimento e na avaliação do treinamento físico e esportivo.Palavras-chave: composição corporal, validação cruzada, DEXA, adultos. ABSTRACTDifferent anthropometric equations have been developed and cross-validated for its use in distinct populations through multicompartimentals models. Dual energy X-ray absorptiometry (DEXA) is a multicompartimental alternative for body composition assessment, however, in Brazil, this model still is not often used, especially for the analysis of the muscle mass (MM). Thus, the purpose of this study was to cross-validate anthropometric equations to estimate relative body fat and MM from DEXA, in young male Brazilian college students. For this, 131 young adults between 18 and 36 years (73,9 ± 9,7 kg; 177,6 ± 6,4 cm; MM = 32,1 ± 3,6 kg) had been evaluated by means of DEXA and anthropometric measures (body mass, stature, circumferences and skinfold thicknesses), been analyzed four equations for the calculation of the MM. The following analysis were applied: descriptive statistics, procedures of cross-validation and analysis of agreement (ICC and Bland and Altman). (-0,77) and the good agreements fond (from moderate to high). New cross-validation studies are suggested in different samples, using DEXA as the reference method, as well is suggested a greater utilization of anthropometric equations for the assessment of MM, for the following of MM changes in relation to the growth, development and aging process, and in the evaluation of the physical and sports training.

show abstract

Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults

Cited by 175 publications

References 21 publications

Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men

Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men

Body composition and bone mineral density in women with Cushing's syndrome in remission and the association with common genetic variants influencing glucocorticoid sensitivity

Validação de equações antropométricas para a estimativa da massa muscular por meio de absortometria radiológica de dupla energia em universitários do sexo masculino

Contact Info

Product

Resources

About