Internal image (Ab2β) anti-idiotype vaccines. Theoretical and practical aspects

Poskitt, D.C.; Jean-Francois, M. J. B.; Turnbull, S.; Macdonald, L.; Yasmeen, D.

doi:10.1016/0264-410x(91)90215-r

Cited by 15 publications

(8 citation statements)

References 40 publications

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“…A true internal-image molecule can induce immune-mediated responses similar to those induced by the original antigen, and this property has, in fact, been used to produce vaccines (reviewed in refs. 5 and 6). Thus, there may be significant structural mimicry between the complementarity-determining regions (CDRs) of internal-image Ab2s and the original antigen.…”

mentioning

confidence: 99%

Crystal structure of an idiotype-anti-idiotype Fabcomplex.

Ban

Escobar

Garcia

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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Anti-idiotypic monoclonal antibody 409.5.3 is raised against an antibody that neutralizes feline Infectious peritonitis virus. This antibody, used as an immunogen, elicits the production of anti-anti-idiotypic antibodies that in turn neutralize the virus. The crystal structure of the complex between anti-idiotypic Fab 409.5.3 and idiotypic Fab fragment of virus-neutraling antibody has been solved by molecular replacement using real-space Patterson search and filtering by Patterson correlation-coefficient refinement. The structure has been refined to an R value of 0.21 based on 21,310 unique reflections between 40.0 and 2.9 A. The three-dimensional structure reveals extensive, specific interactions that involve 118 van der Waals contacts and at least 9 probable hydrogen bonds. The two Fabs are rotated 610 with respect to each other around the approximate long axis ofthe complex and are within 26°of being aligned along their major axes.According to the Jerne hypothesis (1), the immune system responds to foreign substances as a regulatory network composed of idiotypes (Abis)

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mentioning

confidence: 99%

Crystal structure of an idiotype-anti-idiotype Fabcomplex.

Ban

Escobar

Garcia

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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“…In addition, the epitopes recognized with these protective anti-Ids were different. As previously reported [12], although a single anti-Id antibody can be used for immunization against an infectious organism, different epitopes may be instrumental in stimulating the various aspects of immunity required for effective protection. It is possible that vaccines composed of a cocktail of the appropriate anti-Id antibodies may 187 be effective for vaccination.…”

Section: Discussionmentioning

confidence: 81%

Protection of mice against Clostridium chauvoei infection by anti-idiotype antibody to a monoclonal antibody to flagella

Kijima-Tanaka

1994

FEMS Immunology and Medical Microbiology

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Polyclonal rabbit anti-idiotypic antibody (anti-Id) against the protective monoclonal antibody specific to the flagella of Clostridium chauvoei was produced, purified, and characterized. Anti-Id inhibited the binding of its related monoclonal antibody to the flagellar antigen, suggesting that the anti-Id bore an internal image of the flagellar antigen. When mice were immunized with anti-Id intraperitoneally, the survival rate increased significantly, compared with mice immunized with normal rabbit IgG (P < 0.01), and specific anti-flagellar antibodies were induced.

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“…These anti-idiotope antibodies have potential for use in the development of vaccines; thus it may be possible to utilize the Ab2/? for antigen mimicry and to cause the host's immune response to produce antibodies by injecting the anti-Id alone, without exposing the host to potentially dangerous antigen (Dreesman et al, 1985;Moller, 1986;Poskitt et al, 1991). We report on the production and the properties of anti-idiotypic antibodies raised against the murine monoclonal antibody ISS/32, which has been shown to possess protective activity (Ciuchini et al, 1989;Adone et al, 1991).…”

Section: Introductionmentioning

confidence: 85%

Production and characterization of rabbit anti-idiotypic antibodies directed against a murine monoclonal anti-B. abortus antibody

et al. 1995

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The protective anti-beta abortus monoclonal antibody ISS/32 (Ab1) was used as an immunogen to induce anti-idiotypic antibodies (Ab2) in rabbits. The purpose was to produce and characterize anti-idiotypic antibodies that share conformational similarity with the corresponding bacterial epitope recognized by Ab1. The rabbit anti-IdAb so induced was isolated and affinity-purified. Its specificity for the paratope of Ab1 was determined by evaluating its ability to compete with B. abortus for binding to Ab1 in a competitive ELISA assay. The anti-idiotypic ISS/32 antibodies were able to compete with B. abortus for binding to Ab1 in a dose-dependent manner. Hence, the data indicated that the rabbit anti-Id ISS/32 antibodies reacted with or near the antigen-binding site of Ab1.

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Internal image (Ab2β) anti-idiotype vaccines. Theoretical and practical aspects

Cited by 15 publications

References 40 publications

Crystal structure of an idiotype-anti-idiotype Fabcomplex.

Crystal structure of an idiotype-anti-idiotype Fabcomplex.

Protection of mice against Clostridium chauvoei infection by anti-idiotype antibody to a monoclonal antibody to flagella

Production and characterization of rabbit anti-idiotypic antibodies directed against a murine monoclonal anti-B. abortus antibody

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