Internal Ophthalmic Arteries Within the Brain‐Base Arterial System in Guinea Pig

Kuchinka, Jacek

doi:10.1002/ar.23737

Cited by 5 publications

(9 citation statements)

References 15 publications

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“…A partial explanation may lie in the arterial system. Multiple animal studies investigating vasculature found interophthalmic arteries present in rabbits and guinea pigs, providing a possible route for the transfer of drugs as well as materials produced in response to trauma (Forster et al, 1979 ; Kuchinka, 2017 ). While the mechanisms underlying these interocular effects are not fully understood, it is interesting that we only observed contralateral damage in the SNP animals.…”

Section: Discussionmentioning

confidence: 99%

Chemically induced cone degeneration in the 13-lined ground squirrel

Follett,

Warr,

Grieshop

et al. 2024

Vis Neurosci

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Animal models of retinal degeneration are critical for understanding disease and testing potential therapies. Inducing degeneration commonly involves the administration of chemicals that kill photoreceptors by disrupting metabolic pathways, signaling pathways, or protein synthesis. While chemically induced degeneration has been demonstrated in a variety of animals (mice, rats, rabbits, felines, 13-lined ground squirrels (13-LGS), pigs, chicks), few studies have used noninvasive high-resolution retinal imaging to monitor the in vivo cellular effects. Here, we used longitudinal scanning light ophthalmoscopy (SLO), optical coherence tomography, and adaptive optics SLO imaging in the euthermic, cone-dominant 13-LGS (46 animals, 52 eyes) to examine retinal structure following intravitreal injections of chemicals, which were previously shown to induce photoreceptor degeneration, throughout the active season of 2019 and 2020. We found that iodoacetic acid induced severe pan-retinal damage in all but one eye, which received the lowest concentration. While sodium nitroprusside successfully induced degeneration of the outer retinal layers, the results were variable, and damage was also observed in 50% of contralateral control eyes. Adenosine triphosphate and tunicamycin induced outer retinal specific damage with varying results, while eyes injected with thapsigargin did not show signs of degeneration. Given the variability of damage we observed, follow-up studies examining the possible physiological origins of this variability are critical. These additional studies should further advance the utility of chemically induced photoreceptor degeneration models in the cone-dominant 13-LGS.

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Section: Discussionmentioning

confidence: 99%

Chemically induced cone degeneration in the 13-lined ground squirrel

Follett,

Warr,

Grieshop

et al. 2024

Vis Neurosci

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“…However, in camels, it resembles the number "8" (Kiełtyka-Kurc et al, 2014), as in the American tapir (Frąckowiak & Giejdasz, 1998), while in equines, it takes the shape of a rectangle (Frąckowiak & Giejdasz, 1998). In rodents, the shape of the arterial circle of the brain resembles an ellipse (Aydin, 2008;Aydin et al, 2005Aydin et al, , 2009Azambuja et al, 2018;Brudnicki et al, 2014;Kuchinka, 2017aKuchinka, , 2017bSilva et al, 2016). In animals from the order of lagomorphs (Lagomorpha), the shape of the arterial circle of the brain is very specific, similar to that of an hourglass (Brudnicki et al, 2012(Brudnicki et al, , 2015.…”

Section: Discussionmentioning

confidence: 99%

Arterial circle of the brain in the common wildebeest (Connochaetes taurinus)

Zdun

Melnyk

Ruszkowski

et al. 2022

The Anatomical Record

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The main aim of this study was to analyze the arterial circle of the brain and rostral epidural rete mirabile in specimens of the common wildebeest (Connochaetes taurinus). The arterial circle of the brain is a circulatory anastomosis that supplies blood to particular lobes of the brain and surrounding structures. The study was conducted on male and female adults (n = 12) by bilateral injection of an acetone solution of vinyl superchloride or latex LBS3060, which resulted in a cast of arteries of the head and encephalic base. We describe the exact structure of the arterial circle of the brain and rostral epidural rete mirabile. The shape of the arterial circle of the brain in the common wildebeest is heart‐shaped, as in other Bovidae. It is formed by bilateral rostral cerebral arteries, caudal communicating arteries, and the basilar artery, with a general pattern of vessels forming and branching off from the arterial circle of the brain, as described in other ruminants. The rostral cerebral and caudal communicating arteries emerge from an intracranial segment of the internal carotid artery, which in turn arises from vessels of the rostral epidural rete mirabile. This structure, well developed in the examined individuals, has mechanisms underlying selective cooling of the brain, protecting animals from hyperthermia, and affecting body water balance.

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“…The results of the final division of the internal carotid artery are two branches: the rostral cerebral artery, and the internal ophthalmic artery. In some rodent species, the internal ophthalmic artery has been found to have a large diameter [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a study that was conducted by König [ 41 ] on domestic cattle, the arterial circle of the brain was open on the rostral side in the majority of the cases. An open arterial circle of the brain was also found in representatives of rodents, such as in the guinea pig [ 36 , 42 ], nutria [ 43 ], the ground squirrel [ 44 ], and the chinchilla [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Usually, the internal ophthalmic artery is a tiny vessel [ 17 ]. The well-developed internal ophthalmic artery has been previously observed in the guinea pig [ 36 ]. In this species, the connection of the previously mentioned vessel to the arterial circle of the brain was similar to the pattern found in the red-necked wallaby; however, the vessel originated from the caudal communicating artery near the middle cerebral artery because of the absence of the internal carotid artery.…”

Section: Discussionmentioning

confidence: 99%

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Arterial Circle of the Brain of the Red-Necked Wallaby (Notamacropus rufogriseus)

Zdun

Ruszkowski

Gogulski

et al. 2022

Animals

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The red-necked wallaby is a medium-sized marsupial species, which have increasingly been kept as pets around the world. In the study, the arterial blood supply for the brain in this species was described. The study was conducted on 50 specimens with two preparation methods. The main artery supplying the brain was the internal carotid artery. The arterial circle of the brain was closed from the caudal side. The anatomy of the arteries of the described region was compared with other groups of mammals. This is the first description of this anatomical area that has been carried out in a marsupial species. Understanding the anatomy of the circulatory system in the wallaby can be valuable for further physiological and pathophysiological studies.

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Internal Ophthalmic Arteries Within the Brain‐Base Arterial System in Guinea Pig

Cited by 5 publications

References 15 publications

Chemically induced cone degeneration in the 13-lined ground squirrel

Chemically induced cone degeneration in the 13-lined ground squirrel

Arterial circle of the brain in the common wildebeest (Connochaetes taurinus)

Arterial Circle of the Brain of the Red-Necked Wallaby (Notamacropus rufogriseus)

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