Internal radiation dose estimation using multiple D‐shuttle dosimeters for positron emission tomography (<scp>PET</scp>): A validation study using<scp>NEMA</scp>body phantom

Islam, Md. Shahidul; Watanuki, S.; Tashiro, Masato; Watabe, Hiroshi

doi:10.1002/mp.13124

Cited by 5 publications

(2 citation statements)

References 49 publications

(106 reference statements)

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“…The Monte Carlo algorithm addresses the stochasticity of radiation interaction with matter [11][12][13][14]. Furuta et al developed novel medical applications for the particle and heavy-ion transport code system (PHITS) MC package [15]. PHITS can calculate the linear energy distribution to estimate the biological effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Biological dosimetric impact of dose-delivery time for hypoxic tumour with modified microdosimetric kinetic model

Kawahara,

Nagata

2023

Rep Pract Oncol Radiother.

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Background: An improved microdosimetric kinetic model (MKM) can address radiobiological effects with prolonged delivery times. However, these do not consider the effects of oxygen. The current study aimed to evaluate the biological dosimetric effects associated with the dose delivery time in hypoxic tumours with improved MKM for photon radiation therapy. Materials and methods:Cell survival was measured under anoxic, hypoxic, and oxic conditions using the Monte Carlo code PHITS. The effect of the dose rate of 0.5-24 Gy/min for the biological dose (D bio ) was estimated using the microdosimetric kinetic model. The dose per fraction and pressure of O 2 (pO 2 ) in the tumour varied from 2 to 20 Gy and from 0.01 to 5.0% pO 2 , respectively. Results:The ratio of the D bio at 1.0-24 Gy/min to that at 0.5 Gy/min (R DR ) was higher at higher doses. The maximum R DR was 1.09 at 1.0 Gy/min, 1.12 at 12 Gy/min, and 1.13 at 24 Gy/min. The ratio of the D bio at 0.01-2.0% of pO 2 to that at 5.0% of pO 2 (R oxy ) was within 0.1 for 2-20 Gy of physical dose. The maximum R oxy was 0.42 at 0.01% pO 2 , 0.76 at 0.4% pO 2 , 0.89 at 1% pO 2 , and 0.96 at 2% pO 2 . Conclusion:Our proposed model can estimate the cell killing and biological dose under hypoxia in a clinical and realistic patient. A shorter dose-delivery time with a higher oxygen distribution increased the radiobiological effect. It was more effective at higher doses per fraction than at lower doses.

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Section: Introductionmentioning

confidence: 99%

Biological dosimetric impact of dose-delivery time for hypoxic tumour with modified microdosimetric kinetic model

Kawahara,

Nagata

2023

Rep Pract Oncol Radiother.

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“…Recently, Furuta and Sato [ 3 ] extensively discussed the medical applications of the Particle and Heavy Ion Transport Code System (PHITS) MC package and its features that would be useful in this particular field. In addition, the PHITS MC package was employed for estimating radiation doses in medical applications [ 13 , 14 ]. Considering the wide applications of the PHITS MC package, we aimed to develop an open-source graphical user interface (GUI) program for the package that could be used to simulate a phantom composed of most commonly used materials during proton irradiations.…”

Section: Introductionmentioning

confidence: 99%

Development of PHITS graphical user interface for simulation of positron emitting radioisotopes production in common biological materials during proton therapy

Beni

Islam

et al. 2022

Journal of Radiation Research

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The Monte Carlo (MC) method is a powerful tool for modeling nuclear radiation interaction with matter. A variety of MC software packages has been developed, especially for applications in radiation therapy. Most widely used MC packages require users to write their own input scripts for their systems, which can be a time consuming and error prone process and requires extensive user experience. In the present work, we have developed a graphical user interface (GUI) bundled with a custom-made 3D OpenGL visualizer for PHITS MC package. The current version focuses on modeling proton induced positron emitting radioisotopes, which in turn can be used for verification of proton ranges in proton therapy. The developed GUI program does not require extensive user experience. The present open-source program is distributed under GPLv3 license that allows users to freely download, modify, recompile and redistribute the program.

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Error evaluation of the D-shuttle dosimeter technique in positron emission tomography study

Islam

Watanuki

Tashiro

et al. 2019

Radiol Phys Technol

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Internal radiation dose estimation using multiple D‐shuttle dosimeters for positron emission tomography (PET): A validation study usingNEMAbody phantom

Abstract: The phantom study showed that our technique worked successfully. This technique could be used to estimate internal radiation dosimetry in a clinical PET study.

Cited by 5 publications

References 49 publications

Biological dosimetric impact of dose-delivery time for hypoxic tumour with modified microdosimetric kinetic model

Biological dosimetric impact of dose-delivery time for hypoxic tumour with modified microdosimetric kinetic model

Development of PHITS graphical user interface for simulation of positron emitting radioisotopes production in common biological materials during proton therapy

Error evaluation of the D-shuttle dosimeter technique in positron emission tomography study

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