Internal structures of the globus pallidus in patients with Parkinson’s disease: evaluation with quantitative susceptibility mapping (QSM)

Ide, Satoru; Kakeda, Shingo; Ueda, Issei; Watanabe, Keita; Murakami, Yu; Moriya, Junji; Ogasawara, Atsushi; Futatsuya, Koichiro; Satô, Tôru; Ohnari, Norihiro; Okada, Kazumasa; Matsuyama, Atsuji; Fujiwara, Hitoshi; Hisaoka, Masanori; Tsuji, Sadatoshi; Liu, Tian; Wang, Yi; Korogi, Yukunori

doi:10.1007/s00330-014-3472-7

Cited by 44 publications

(46 citation statements)

References 27 publications

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“…On the other hand, the lack of a significant age-related difference in the GP with QSM in the present study is consistent with previous post-mortem evidence (Hallgren and Sourander, 1958), and confirmed in vivo (Li et al, 2014), that iron deposition in the GP increases rapidly from birth until the second decade of life but thereafter plateaus. One study, however, reported age-related differences in the GPe-but not GPi-with QSM (Ide et al, 2015). Overall, the differential GP behaviours in the present study are reflected in the existing literature, indeed a meta-analysis of past studies using various MR techniques to estimate iron content concluded that the GP showed the weakest and most inconsistent age-related differences compared to other basal ganglia structures.…”

Section: Discussionsupporting

confidence: 62%

High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R2* measurements at 7 T

et al. 2016

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Quantitative susceptibility mapping (QSM) has recently emerged as a novel magnetic resonance imaging (MRI) method to detect non-haem iron deposition, calcifications, demyelination and vascular lesions in the brain. It has been suggested that QSM is more sensitive than the more conventional quantifiable MRI measure, namely the transverse relaxation rate, R2*. Here, we conducted the first high-resolution, whole-brain, simultaneously acquired, comparative study of the two techniques using 7 Tesla MRI. We asked which of the two techniques would be more sensitive to explore global differences in tissue composition in elderly adults relative to young subjects. Both QSM and R2* revealed strong agerelated differences in subcortical regions, hippocampus and cortical grey matter, particularly in superior frontal regions, motor/premotor cortices, insula and cerebellar regions. Within the basal ganglia system-but also hippocampus and cerebellar dentate nucleus-, QSM was largely in agreement with R2* with the exception of the globus pallidus. QSM, however, provided superior anatomical contrast and revealed age-related differences in the thalamus and in white matter, which were otherwise largely undetected by R2* measurements. In contrast, in occipital cortex, age-related differences were much greater with R2* compared to QSM. The present study, therefore, demonstrated that in vivo QSM using ultra-high field MRI provides a novel means to characterize age-related differences in the human brain, but also combining QSM and R2* using multigradient recalled echo imaging can potentially provide a more complete picture of mineralization, demyelination and/or vascular alterations in aging and disease.

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Section: Discussionsupporting

confidence: 62%

High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R2* measurements at 7 T

et al. 2016

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“…Our previous QSM study with normal subjects mentioned differences in the iron deposition with age between the lateral and medial globus pallidus; the QSM value in the lateral globus pallidus significantly increased gradually with age, whereas that in the medial globus pallidus did not increase [25]. Our current results demonstrated that both SLE groups showed significantly higher QSM and R2* values than the controls for the lateral globus pallidus, but not for the medial globus pallidus.…”

Section: Discussioncontrasting

confidence: 67%

“…As the degree of susceptibility to ferritin is much stronger in the brains of individuals free of haemorrhage and aggregates of other metals than in other tissues, QSM can be used to quantify the brain iron distribution [24]. Ide et al reported, by using QSM, the susceptibility differences between medial and lateral globus pallidus related to age separately [25]. Clinical data obtained from MS patients suggest that QSM is more sensitive than R2* mapping for detecting changes in MS brains [12].…”

Section: Introductionmentioning

confidence: 97%

Quantitative susceptibility mapping in patients with systemic lupus erythematosus: detection of abnormalities in normal-appearing basal ganglia

et al. 2015

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“…With regard to the detection of calcification, several studies suggest that QSM may be superior to conventional SWI in the identification of subtle calcifications and in differentiating microcalcifications from hemosiderin, at the same time also allowing for a quantification [19, 46]. As a consequence, there is a multitude of future clinical applications for QSM, such as in the diagnosis and longitudinal evaluation of quantitative changes in neurodegenerative diseases [47], multiple sclerosis [48] or the prognosis of neoplasms such as glioblastomas [46]. …”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of susceptibility-weighted magnetic resonance imaging for the evaluation of pineal gland calcification

et al. 2017

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ObjectivesTo determine the diagnostic performance of susceptibility-weighted magnetic resonance imaging (SWMR) for the detection of pineal gland calcifications (PGC) compared to conventional magnetic resonance imaging (MRI) sequences, using computed tomography (CT) as a reference standard.Methods384 patients who received a 1.5 Tesla MRI scan including SWMR sequences and a CT scan of the brain between January 2014 and October 2016 were retrospectively evaluated. 346 patients were included in the analysis, of which 214 showed PGC on CT scans. To assess correlation between imaging modalities, the maximum calcification diameter was used. Sensitivity and specificity and intra- and interobserver reliability were calculated for SWMR and conventional MRI sequences.ResultsSWMR reached a sensitivity of 95% (95% CI: 91%-97%) and a specificity of 96% (95% CI: 91%-99%) for the detection of PGC, whereas conventional MRI achieved a sensitivity of 43% (95% CI: 36%-50%) and a specificity of 96% (95% CI: 91%-99%). Detection rates for calcifications in SWMR and conventional MRI differed significantly (95% versus 43%, p<0.001). Diameter measurements between SWMR and CT showed a close correlation (R2 = 0.85, p<0.001) with a slight but not significant overestimation of size (SWMR: 6.5 mm ± 2.5; CT: 5.9 mm ± 2.4, p = 0.02). Interobserver-agreement for diameter measurements was excellent on SWMR (ICC = 0.984, p < 0.0001).ConclusionsCombining SWMR magnitude and phase information enables the accurate detection of PGC and offers a better diagnostic performance than conventional MRI with CT as a reference standard.

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Internal structures of the globus pallidus in patients with Parkinson’s disease: evaluation with quantitative susceptibility mapping (QSM)

Abstract: The QSM value in GPl increases gradually with age, which allows for the identification of GPm in elderly PD subjects.

Cited by 44 publications

References 27 publications

High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R2* measurements at 7 T

High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and R2* measurements at 7 T

Quantitative susceptibility mapping in patients with systemic lupus erythematosus: detection of abnormalities in normal-appearing basal ganglia

Diagnostic accuracy of susceptibility-weighted magnetic resonance imaging for the evaluation of pineal gland calcification

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