With the continuous and deepening of urbanization in my country, more and more migrant laborers appear, accompanied by the emergence of left-behind children. As a representative of children with lower socioeconomic status, left-behind children in rural areas have different degrees of problems in physical and mental health and learning. This article uses China’s education tracking survey data to empirically analyze the impact of parents’going out on the mental health of left-behind children in rural areas. The study found that mothers play an indispensable role in the growth of children and have a significant impact on the development of children’s mental health. Therefore, in the policy of focusing on the protection of left-behind children, it is necessary to rationally allocate the arrangements for parents to take care of home and work outside to create a normal and suitable family atmosphere for the left-behind children.