International challenges of self-sufficiency in blood products

Dhingra, Neelam

doi:10.1016/j.tracli.2013.03.003

Cited by 21 publications

(14 citation statements)

References 2 publications

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“…Demographic changes in industrialised nations have revealed ageing populations and a decreasing donor pool. In addition, as of 2012, only 62 countries (32%) among 193 WHO Member States reported that greater than 99% of their blood supplies were derived from volunteered non‐remunerated blood donors (VNRBT) (Dhingra, ; Greinacher et al ., ). Self‐sufficient transfusions based on VNRBT might be decreasing, while blood products from other nations might be increasing.…”

Section: Discussionmentioning

confidence: 99%

Blood group antigen and phenotype prevalence in the Korean population compared to other ethnic populations and its association with RBC alloantibody frequency

Jekarl

Yoo

Lee

et al. 2019

Transfusion Medicine

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Objectives:This study aimed to analyse the allele frequency of blood group antigens in the Korean population and other ethnic populations and the association of blood group antigens with red blood cell (RBC) alloantibodies.Background: Blood group antigen genotyping can support patients undergoing frequent transfusions who have alloantibodies and antibodies against high-prevalence blood group antigens.Methods: Twenty-nine single nucleotide variations and 37 blood group antigens were tested. Samples requested for routine blood typing were collected from Jan to Apr 2016. Genotyping was performed on 145 Korean samples and was confirmed by bidirectional sequencing and serologic tests. The allele frequency data were compared with previous genotyping datasets (three datasets from Korea and one each from China, Europe, Asia, and the USA). Alloantibody frequencies and blood group antigens from the electronic medical record of 1772 cases were examined.Results: E antigen was higher in the Korean population compared to that of Asian and European populations. K, Kp a , Fy b and Do a allele frequencies were lower compared to other ethnic populations. RBC alloantibodies with frequencies (%) greater than 1% from the 1772 cases were as follows: anti-E, 36·7%, anti-C, 17·7%; anti-c 7·39%; anti-M, 5·9%; anti-e, 5·2%; anti-Jk a , 2·9%; and anti-Fy a , 1·1%. Blood group antigens and alloantibody frequencies revealed inverse trends that did not reach statistical significance. Conclusion:The allele frequency of blood group antigens assessed by high-throughput methods provided reliable and valuable information that could be used for maintaining donor pools and providing compatible blood for genotyped patients.

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Section: Discussionmentioning

confidence: 99%

Blood group antigen and phenotype prevalence in the Korean population compared to other ethnic populations and its association with RBC alloantibody frequency

Jekarl

Yoo

Lee

et al. 2019

Transfusion Medicine

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“…However, despite considerable improvements in eligibility criteria for blood donation and development of more advanced screening methods, transfusion transmitted infectious agents like HBV still present a threat to blood safety . Availability and safety of blood and blood products remain a major concern in many countries around the world and countries are facing unique challenges in ensuring self‐sufficiency in safe blood and blood products based on voluntary non‐remunerated blood donations …”

Section: Introductionmentioning

confidence: 99%

Detection of Hepatitis B Virus DNA among Chronic and potential Occult HBV patients in resource‐limited settings by Loop‐Mediated Isothermal Amplification assay

Akram

Islam

Munshi

et al. 2018

Journal of Viral Hepatitis

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Transmission of Hepatitis B Virus (HBV) usually occurs due to the transfusion of blood or blood products from chronic HBV (CHB) or occult HBV-infected (OBI) patients. Besides serological tests, e.g. HBsAg and anti- HBc (total), detection of HBVDNA is necessary for the diagnosis of OBI patients. Different nucleic acid tests (NATs) including real- time-Polymerase Chain Reaction (qPCR) are used to detect HBV- DNA. The NATs are expensive and require technical expertise which are barriers to introduce them in resource-limited settings. This study was undertaken to evaluate the use of Loop-Mediated Isothermal Amplification (LAMP) assay as an alternative to qPCR for the detection of HBV-DNA in CHB and potential OBI patients in resource-limited settings. Following the published protocols with some modifications, a LAMP assay was developed for detection of HBV-DNA by either using a heat block followed by detection in an agarose gel or using a qPCR thermocycler. The LAMP assay was applied to supernatant prepared from heat-treated serum collected from CHB and potential OBI patients. HBV viral load in serum was measured by qPCR using a single-step HBV-DNA quantification kit. Among 200 samples tested, qPCR was capable to detect HBV-DNA in 25.5% of cases, whereas LAMP assay detected HBV-DNA in 43.5% cases. The qPCR was able to detect 11 (9.16%) potential OBI cases, whereas LAMP assay identified HBV-DNA in 43 (35.83%) cases. In addition to tests for HBsAg and/or anti-HBc (total), detection of HBV-DNA by LAMP assay may aid in preventing post-transfusion HBV infection in resource-limited settings.

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“…Cerca de 14 milhões de unidades de Concentrados de Hemácias (CH) são transfundidas por ano, representando custo aproximado de US$ 3 bilhões (média de US$ 225 por CH). Além dos custos onerosos, a disponibilidade, segurança da mais alta qualidade do sangue e de seus produtos e a autossuficiência baseada em doadores voluntários não remunerados são desafios que todos os países enfrentam para responder as ameaças conhecidas e emergentes para saúde pública (Bittencourt R, Costa J, Lobo JEO, Aguiar FC, 2012); (Dhingra N, 2013) .…”

Section: Introductionunclassified

Avanços E Desafios Para Segurança Nas Transfusões De Sangue

Santos¹,

Santos²,

Pinho³

et al. 2020

Saúde Pública No Século Xxi: Uma Abordagem Sobre Política E Gestão Em Saúde

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Quando o Sistema Único de Saúde, concebido de um espírito inovador e igualitário, foi criado em 1988, não se dimensionava o que ele traria como contribuição e os desafios colossais que viriam. E mesmo passando por tantas situações vexatórias, o conhecido SUS, é um exemplo para outros países copiarem seu modelo de atendimento humanitário. Por mais que nos queixemos da qualidade dos serviços e do sucateamento das unidades de atendimento, sem ele a desigualdade social de nosso país seria abissal. Portanto, o deve do Estado de fornecer saúde de qualidade a todos, ainda é, por mais desumana que pareça ser, a primeira vista. Aqueles que a constituem, são pessoas que dedicam ao ponto de literalmente, dar a vida para que outros possam ser atendidos com o mínimo de dignidade. Nesse momento sanitário que a humanidade encara, muitas vidas foram salvas pelos nossos profissionais de saúde, que não se resumem apenas pelos profissionais de medicina, mas por uma área multiprofissional que vai desde a logística até a telemedicina e cirurgia robótica. Na base de toda essa máquina, com um sistema intricado e complexo, as pequenas partes deste circuito de geração de saúde, são os acadêmicos e pesquisadores que se entregam por inteiro, sem querer o devido reconhecimento por suas contribuições. E é essa perspectiva que esperamos dos leitores desta obra. A visão de que os capítulos que a compõe, são resultado de esforço e dedicação em prol da saúde.Em nossos livros selecionamos um dos capítulos para premiação como forma de incentivo para os autores, e entre os excelentes trabalhos selecionados para compor este livro, o premiado foi o capítulo 1, intitulado "Principais impasses assistenciais da atenção primária à saúde diante da pandemia provocada pelo novo coronavírus".

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International challenges of self-sufficiency in blood products

Cited by 21 publications

References 2 publications

Blood group antigen and phenotype prevalence in the Korean population compared to other ethnic populations and its association with RBC alloantibody frequency

Blood group antigen and phenotype prevalence in the Korean population compared to other ethnic populations and its association with RBC alloantibody frequency

Detection of Hepatitis B Virus DNA among Chronic and potential Occult HBV patients in resource‐limited settings by Loop‐Mediated Isothermal Amplification assay

Avanços E Desafios Para Segurança Nas Transfusões De Sangue

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