International collaborative study on standardization of bacterial sensitivity to fosfomycin

Andrews, J. M.; Baquero, Fernando; Beltrán, Jesús Martínez; Cantón, Emilia; Crokaert, Françoise; Gobernado, M; Gómez-Lus, R; Loza, Elena; Navarro, Manuel Nevot; Olay, T.; Rodríguez, Anai Moreno; Vicente, M. V.; Wise, R.; Yourassowsky, E

doi:10.1093/jac/12.4.357

Cited by 44 publications

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“…The MIC of FOF was determined using the broth microdilution method in cation-adjusted Mueller-Hinton broth (CAMHB) supplemented with glucose-6-phosphate (Sigma-Aldrich) at a final concentration of 25 mg/liter (12). The MIC of VAN was determined by using the epsilometer test (Etest) method.…”

Section: Methodsmentioning

confidence: 99%

Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

Poeppl

Lingscheid

Bernitzky

et al. 2014

Antimicrob Agents Chemother

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. In the fosfomycin group, MRSA was detectable in 2 out of 10 (20%) animals (3.42 ؋ 10 2 and 1.51 ؋ 10 3 CFU/g of bone). Vancomycin was superior to the no-drug control (P ‫؍‬ 0.002), and fosfomycin was superior to the no-drug control and vancomycin (P < 0.001). The cultures from the wires were positive in all untreated animals (median, 2.5 ؋ 10 3 CFU/implant), in 10 animals in the vancomycin group (median, 1.15 ؋ 10 3 CFU/ implant), and negative in all animals in the fosfomycin group. Based on the bacterial counts from the implants, vancomycin was not superior to the no-drug control (P ‫؍‬ 0.324), and fosfomycin was superior to the no-drug control and vancomycin (P < 0.001). No emergence of resistance was observed. In conclusion, it was demonstrated that fosfomycin monotherapy is highly effective for the treatment of experimental implant-associated MRSA osteomyelitis.

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Section: Methodsmentioning

confidence: 99%

Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

Poeppl

Lingscheid

Bernitzky

et al. 2014

Antimicrob Agents Chemother

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“…Resistance to fosfomycin was considered when the MIC was ≥128 µg/ml ( Andrews et al, 1983). All susceptibility data were confirmed on at least two separate experiments.…”

Section: Antimicrobial Agents and Susceptibility Testingmentioning

confidence: 99%

Molecular identification and antimicrobial resistance profiles of Campylobacter strains of poultry origin in India with special emphasis on fluoroquinolone resistance

Kabir

Asakura

Shiramaru

et al. 2015

Asian J. Med. Biol. Res

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Abstract:The current study aimed to identify the selected number of Campylobacter strains of poultry origin in India that were isolated in the Laboratory of International Prevention of Epidemics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Japan to the species level with the aid of cdtA/B/C gene-based multiplex PCR assays as well as to investigate their antimicrobial resistance profiles. C. jejuni (4 strains) and C. coli (16 strains) were identified. The poultry isolates identified were subjected to susceptibility testing with the aid of disk diffusion method using 12 antimicrobial agents. Again, the resistant and intermediate isolates confirmed by the disk diffusion method were subjected to determination of minimum inhibitory concentration by agar dilution method. To elucidate the mechanism of quinolone resistance, a total number of 20 quinolone resistant strains were subjected to sequence determination and analysis of the gyrA gene in the quinolone-resistance determining region. The results of the disk diffusion method were consistent with the results of the agar dilution method with slight variation in case of ampicillin, levofloxacin, ofloxacin and fosfomycin. All C. jejuni and C. coli strains had the Thr 86 to Ile substitution in gyrA. Results of this study support the emergence of resistance of C. jejuni and C. coli strains of poultry origin in India to a variety of antimicrobials especially fluoroquinolones.

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“…All MICs were determined by an agar dilution method with Mueller-Hinton agar (Unipath) supplemented with 5% sheep blood containing graded concentrations of antibiotics. The fosfomycin plates were prepared by the addition of 25 g of glucose 6-phosphate per ml to the medium as recommended previously (1).…”

mentioning

confidence: 99%

Susceptibilities of fluoroquinolone-resistant strains of Campylobacter jejuni to 11 oral antimicrobial agents

Gómez-Garcés

Cogollos

Alos

1995

Antimicrob Agents Chemother

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The resistance of Campylobacter jejuni strains to the fluoroquinolones is increasingly frequent, and in our area it reaches nearly 50%. We studied the susceptibilities of 60 of these strains to 11 oral antibiotics. All strains except one were susceptible to the macrolides tested, with azithromycin being the most active agent tested. Of the rest of the antibiotics studied, amoxicillin-clavulanic acid, clindamycin, and fosfomycin displayed good in vitro activities. Knowledge of the susceptibilities of these microorganisms to a varied group of oral agents is necessary in view of the appearance of multiresistant strains, such as those included in our series.

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International collaborative study on standardization of bacterial sensitivity to fosfomycin

Cited by 44 publications

References 0 publications

Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

Molecular identification and antimicrobial resistance profiles of Campylobacter strains of poultry origin in India with special emphasis on fluoroquinolone resistance

Susceptibilities of fluoroquinolone-resistant strains of Campylobacter jejuni to 11 oral antimicrobial agents

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