After the Arab uprising of the early 2010s which changed the geopolitical shape of the Eastern Mediterranean, the Abraham Accords in 2020 marked the second most momentous development of the past decade, which drove more external players to the scene of geopolitics of the Mediterranean region. The Abraham Accords improved Israel’s relations with some Arab states of the Persian Gulf such as the UAE, Bahrain and Saudi Arabia and paved their way, under the full support of the United States, to heavily partake in geopolitical and geostrategic equations, mainly on energy and security nature, of the Eastern Mediterranean formulated mainly by Greece under the Neo-Democracy government. The present research explores the changing character of geopolitics in the Mediterranean and how Greece is playing its role in restructuring such a character. Findings of this research suggest that Greece is playing a prominent and leading role in transforming the geopolitics of the Eastern Mediterranean through security and energy initiatives for protection against possible aggression from Turkiye. Considering the supreme importance of the Mediterranean commercially and militarily for the United States, this article argues that the new design of geopolitics in the region is being shaped to protect Greece and Israeli interests in favour of the USA in the Eastern Mediterranean.