“…Several expert panel consensus statements have endorsed routine use of topical tranexamic acid for hip and knee arthroplasty, but there are currently no major guideline recommendations for orthopaedic surgeons [2,6]. In order to determine the direction and strength of a recommendation, guidelines panels should integrate confidence in the pooled effect estimates, the balance of desirable and undesirable outcomes among alternative management strategies, the values and preferences of typical patients, and the potential use of healthcare resources [1].…”