International Dissemination of a High Virulence Rabbit <i>Staphylococcus aureus</i> Clone

Vancraeynest, Dieter; Haesebrouck, Freddy; Deplano, Ariane; Denis, Olivier; Godard, C.; Wildemauwe, Christa; Hermans, Katleen

doi:10.1111/j.1439-0450.2006.00977.x

Cited by 61 publications

(42 citation statements)

References 38 publications

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“…However, if the rabbit survives this phase, abscesses may be developed in many internal organs as heart, kidney, lungs, liver, spleen, testes and in joints leading to osteomyelitis (Abdel-Gwad et al 2004). At rabbit flock level, two types of S. aureus infections are distinguished-the first type caused by low-virulence strains which is limited to individual animals and the second type caused by high-virulence strains which lead to chronic problems throughout the rabbitry (Hermans et al 1999;Vancraeynest et al 2006). Rabbit skin is thin and easily traumatised (Harcourt-Brown 2002).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance and species identification of staphylococci isolated from the meat of wild rabbits (Oryctolagus cuniculus) in Slovakia

et al. 2011

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In 2009, a total of 113 strains of staphylococci were isolated from the thigh muscles of ten hunted and 20 farmed wild rabbits (Oryctolagus cuniculus) in the Slovak Republic. Only two isolates (1.8%) possessed coagulase activity, the rest of 111 staphylococcal isolates were coagulase-negative. Among them, six isolates (5.4%) showed the production of DNase. In each isolate, resistance to eight antibiotics by means of agar dilution test was tested. Based on these results, 110 isolates were found to be resistant to at least one antibiotic. Only one isolate was susceptible to all eight antibiotics tested. Another two isolates were susceptible, however, they showed intermediate susceptibility to cefoxitin. Resistance to ampicillin (78.8%), erythromycin (58.4%), penicillin (51.3%) and oxacillin (46.0%) was found most frequently. Twenty-six isolates (23.0%) were resistant to novobiocin. On the other hand, resistance to cefoxitin (8.0%) and gentamicin (1.8%) were quite rare. Fifteen percent of isolates were resistant to one antibiotic, simultaneous resistance to two, three, four and five antibiotics was confirmed in 22.1%, 23.9%, 21.2% and 13.3% of isolates, respectively. Except for two coagulase-positive Staphylococcus aureus isolates (1.8%), seven species of coagulase-negative staphylococci were identified using the MALDI BioTyper (TM) sytem as follows: Staphylococcus warneri (45.1%), Staphylococcus epidermidis (21.2%), Staphylococcus pasteuri (13.3%), Staphylococcus xylosus (8.0%), Staphylococcus capitis (7.1%), Staphylococcus haemolyticus (1.8%) and Staphylococcus cohnii ssp cohnii (1.8%).

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Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance and species identification of staphylococci isolated from the meat of wild rabbits (Oryctolagus cuniculus) in Slovakia

et al. 2011

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“…Nevertheless, it is known that the administration of purified PVL into the skin of rabbits results in inflammation 99 and necrosis 123 . Notably, data that generated using rabbit models should be interpreted with caution, as many rabbits have been previously exposed to S. aureus , resulting in the presence of antibodies 127 , which could mask the contribution of virulence factors to infection and pathogenesis.…”

Section: Therapeuticsmentioning

confidence: 99%

Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors

2017

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PREFACE Staphylococcus aureus is a major bacterial pathogen that causes disease worldwide. The emergence of strains that are resistant to commonly used antibiotics and the failure of vaccine development has resulted in a renewed interest in the pathophysiology of S. aureus. The staphylococcal leukocidins are a family of bi-component pore-forming toxins that are important virulence factors. During the past five years, cellular receptors have been identified for all of the bi-component leukocidins. The identification of the leukocidin receptors explains the cellular tropism and species specificity that is exhibited by these toxins, which has important biological consequences. In this review, we summarize the recent discoveries that have refueled the interest in these toxins and we provide an outlook for future research.

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“…aureus is a versatile opportunistic pathogen that causes a wide spectrum of pathologies (22). This bacterium affects rabbits of different ages, infects dermal lesions and invades subcutaneous tissues (23), resulting in different pathologies, including subcutaneous abscesses, exudative and supportive dermatitis (24,25); pododermatitis (26,27); mastitis (26); infertility and death (28). Economic losses in industrial livestock husbandry attributed to staphylococcal infections are considerable at a worldwide.…”

Section: Introductionmentioning

confidence: 99%

Study on the total proteins and main protein fractions in rabbits experimentally infected with Staphylococcus aureus

Georgieva¹,

Petrov²,

Georgiev³

et al. 2017

TJS

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Infections with Staphylococcus aureus are a common cause which can induce severe skin infections in rabbits leading to important economic losses. The present study was conducted to evaluate the changes in the concentrations of total protein, albumin, globulin, fibrinogen, and albumin/globulin ratio during S. aureus infection using a model for experimental infection of rabbits. The experiment was carried out on 13 rabbits at the age of 3 months. Infection was induced by inoculation of 7 rabbits by100 μL of bacterial suspension of a field S. aureus strain (density: 8х10 8 cfu/mL) and 6 other rabbits were not treated (controls). Blood samples for principal protein analysis were collected before (0 h) and at 24, 48 and72 h on day 7, 14, and 21 after infection. Total protein level showed little changes in the experimental group. The concentration of albumin decreased in the experimental group since 32.2±2.30 g/L to 27.3±1.9g/L. The serum level of globulins rose significantly (P<0.05) in the experimental group and slightly in the control group. Albumin/globulin ratio was lowered and significantly different on day 4 (P<0.01) and on day 7 (P<0.001). The concentration of fibrinogen was used as an acute phase protein with aim to confirm the incidence of infection. In parallel, rectal temperature and skin lesions (abscesses) were recorded. In all infected animals, formation of abscess due to the proliferation of the inoculated strain was observed within 48-96 h following the bacterial inoculation and these lesions have gradually extended leading to purulent exudates several days after and sometimes to secondary abscesses in surrounding muscles.

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International Dissemination of a High Virulence Rabbit Staphylococcus aureus Clone

Cited by 61 publications

References 38 publications

Antimicrobial resistance and species identification of staphylococci isolated from the meat of wild rabbits (Oryctolagus cuniculus) in Slovakia

Antimicrobial resistance and species identification of staphylococci isolated from the meat of wild rabbits (Oryctolagus cuniculus) in Slovakia

Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors

Study on the total proteins and main protein fractions in rabbits experimentally infected with Staphylococcus aureus

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