International Energy Law and Policy

(, T.W. Wälde

doi:10.1016/b0-12-176480-x/00162-5

Cited by 7 publications

(7 citation statements)

References 1 publication

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“…MLVs were prepared in the presence of increasing molar fractions of the studied coumarins, and the related calorimetric curves were compared with that of MLVs prepared in the absence of the compounds evaluated (Figure ). The calorimetric curve of unloaded MLVs is characterized by two endothermic peaks: a pretransition peak, at about 16.5 °C, associated with the hydrophobic chain tilt, and a main peak, at 24.4 °C, related to the transition from an ordered gel state to a disordered liquid crystalline state …”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Interaction of Coumarins with Biomembrane Models Studied by Differential Scanning Calorimetry and Langmuir−Blodgett Techniques

et al. 2011

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Three coumarins, scopoletin (1), esculetin (2), and esculin (3), were investigated by differential scanning calorimetry and Langmuir-Blodgett techniques to gain information about the interaction of these compounds with cellular membranes. Phospholipids assembled as multilamellar vesicles or monolayers (at the air-water interface) were used as biomembrane models. Differential scanning calorimetry was employed to study the interaction of these coumarins with multilamellar vesicles and to evaluate their absorption by multilamellar vesicles. These experiments indicated that 1-3 interact in this manner to different extents. The Langmuir-Blodgett technique was used to study the effect of these coumarins on the organization of phospholipids assembled as a monolayer. The data obtained were in agreement with those obtained in the calorimetric experiments.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the Interaction of Coumarins with Biomembrane Models Studied by Differential Scanning Calorimetry and Langmuir−Blodgett Techniques

et al. 2011

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“…On heating, phosphatidylcholine bilayers exhibit a pretransition and a main phase transition. The pretransition corresponds to the conversion of the lamellar gel phase to the rippled gel phase and is mainly related to the polar region of phosphatidylcholine bilayers; the main phase transition corresponds to the change from the rippled gel phase to the liquid crystal phase and is closely related to the acyl chains of phosphatidylcholine bilayers. , Exogenous substances present in the phospholipid bilayers can cause variation both in the pretransition and in the main transition. , Then, the phase transitions of phosphatidylcholine can be used to evaluate the interaction between the acyl chains of phosphatidylcholine and exogenous substances…”

Section: Results and Discussionmentioning

confidence: 99%

Interaction of α-Hexylcinnamaldehyde with a Biomembrane Model: A Possible MDR Reversal Mechanism

et al. 2015

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The ability of the naturally derived compound α-hexylcinnamaldehyde (1) to interact with biomembranes and to modulate their permeability has been investigated as a strategy to reverse multidrug resistance (MDR) in cancer cells. Dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLVs) were used as biomembrane models, and differential scanning calorimetry was applied to measure the effect of 1 on the thermotropic behavior of DMPC MLVs. The effect of an aqueous medium or a lipid carrier on the uptake of 1 by the biomembrane was also characterized. Furthermore, taking into account that MDR is strictly regulated by redox signaling, the pro-oxidant and/or antioxidant effects of 1 were evaluated by the crocin-bleaching assay, in both hydrophilic and lipophilic environments. Compound 1 was uniformly distributed in the phospholipid bilayers and deeply interacted with DMPC MLVs, intercalating among the phospholipid acyl chains and thus decreasing their cooperativity. The lipophilic medium allowed the absorption of 1 into the phospholipid membrane. In the crocin-bleaching assay, the substance produced no pro-oxidant effects in both hydrophilic and lipophilic environments; conversely, a significant inhibition of AAPH-induced oxidation was exerted in hydrophilic medium. These results suggest a possible role of 1 as a chemopreventive and chemosensitizing agent for fighting cancer.

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“…These two events produce two well-defined calorimetric peaks, respectively. The first is less energetic and occurs at about 17 °C, and is called the pretransition peak, whereas the second, at about 25 °C, is termed the main transition peak. , Any compound interacting with MLVs can cause variations of both the pretransition peak and the main transition peak and, in particular, can affect the thermotropic parameters of the peaks: pretransition and transition temperature and enthalpy change. − The calorimetric curves of MLVs prepared with 4 or 5 , together with that of MLVs prepared without either compound, are shown in Figure A and B. Compound 4 caused the disappearance of the pretransition peak at all molar fractions used, whereas the transition peak broadened and moved toward lower temperature, as the compound molar fraction increased.…”

Section: Resultsmentioning

confidence: 99%

Effect of Resveratrol-Related Stilbenoids on Biomembrane Models

et al. 2013

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The interactions of the two resveratrol analogues 2-hydroxy-3,5,3',5'-tetramethoxystilbene (4) and 2-hydroxy-3,5,3',4'-tetramethoxystilbene (5) with model biomembranes were studied. The aim of this investigation was to highlight possible differences in the interactions with such biomembranes related to the minimal structural differences between these isomeric stilbenoids. In particular, different experiments on stilbenoid/biomembrane model systems using both differential scanning calorimetry (DSC) and Langmuir-Blodgett techniques were carried out to evaluate stilbenoid/multilamellar vesicle and stilbenoid/phospholipid monolayer interactions, respectively. Dimyristoylphosphatidylcholine was used as constituent of the biomembrane models and permitted the experiments to be carried out at 37 °C, close to body temperature. Kinetic studies were also run by DSC to evaluate the uptake of the resveratrol derivatives by the biomembrane model in an aqueous medium and when transported by a lipophilic carrier. The results indicated that both of the resveratrol analogues influenced the behavior of multilamellar vesicles and monolayers, biomembrane models, with 4 producing a larger effect than 5. These results are useful for better understanding the mechanism of action of these compounds. Moreover, the kinetic results could be of importance for future design of lipophilic delivery systems for these stilbenoids.

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International Energy Law and Policy

Cited by 7 publications

References 1 publication

Evaluation of the Interaction of Coumarins with Biomembrane Models Studied by Differential Scanning Calorimetry and Langmuir−Blodgett Techniques

Evaluation of the Interaction of Coumarins with Biomembrane Models Studied by Differential Scanning Calorimetry and Langmuir−Blodgett Techniques

Interaction of α-Hexylcinnamaldehyde with a Biomembrane Model: A Possible MDR Reversal Mechanism

Effect of Resveratrol-Related Stilbenoids on Biomembrane Models

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