International harmonisation of Anthelmintic Efficacy Guidelines

Vercruysse, Jozef; Holdsworth, P. J.; Letonja, T; Barth, D.; Conder, George A.; Hamamoto, Kouko; Okano, Kazuhiro

doi:10.1016/s0304-4017(00)00443-x

Cited by 166 publications

(90 citation statements)

References 1 publication

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“…Lower doses will show efficacy <90% for the dose-limiting species even though they will adequately treat other parasites (i.e., efficacy ≥ 90%) (Vercruysse et al, 2001). Dose-limiting species can be vulnerable to selection for AR and at least on some occasions have been the first to reveal resistance, as is clearly evidenced with the MLs and cattle parasites.…”

Section: Specific Targeting Of Dose-limiting Speciesmentioning

confidence: 99%

“…guidelines (Jacobs et al, 1994;Wood et al, 1995;Duncan et al, 2002;Yazwinski et al, 2003;Hennessy et al, 2006) and VICH (Anonymous, 1999a(Anonymous, ,b, 2000a(Anonymous, ,c, 2001Vercruysse et al, 2001.…”

Section: Efficacy Guideline For Regulatory Approval/registration Of Amentioning

confidence: 99%

“…This guideline does not consist of rigid stipulations, but instead makes recommendations on the minimum studies required (Wood et al, 1995;Vercruysse et al, 2001). Guidelines cannot address all possibilities and each case should be considered on its merits; if alternative approaches are deemed more fitting, a reasoned argument should be discussed with regulatory agencies in the target jurisdiction.…”

Section: Objectives Of the Anthelmintic Combination Guidelinementioning

confidence: 99%

“…and VICH guidelines for general efficacy of anthelmintics (Anonymous, 1999a(Anonymous, ,b, 2000a(Anonymous, ,c, 2001Vercruysse et al, 2001.…”

Section: Objectives Of the Anthelmintic Combination Guidelinementioning

confidence: 99%

“…(Wood et al, 1995;Duncan et al, 2002) and VICH (Anonymous, 1999a(Anonymous, ,b, 2000aVercruysse et al, 2001 guidelines. If claims of synergy are made, conclusive evidence supporting lowered doses (if used) must be provided in accordance with the relevant guidelines.…”

Section: Dose Determination Data On the Anthelmintic Constituent Actimentioning

confidence: 99%

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World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guideline: Anthelmintic combination products targeting nematode infections of ruminants and horses

Geary

Hosking

Skuce

et al. 2012

Veterinary Parasitology

100

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a b s t r a c tIncreasing threats from anthelmintic resistant nematode populations warrant and motivate a reappraisal of chemotherapeutic strategies for nematode control in ruminant livestock and horses. The objective of this paper is to present a guideline for the evaluation of products containing two or more constituent anthelmintic actives in a single dosage form for the treatment of nematode infections in these animals. At present, regulatory policies on the approval of such products vary across jurisdictions, and this World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guideline should enable the harmonization of the requirements. This guideline makes clear recommendations on the minimal standards needed, but stresses that registration dossiers for combination anthelmintic products submitted for approval must conform to the standards and practices already established in existing guidelines for anthelmintics.

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Section: Specific Targeting Of Dose-limiting Speciesmentioning

confidence: 99%

Section: Efficacy Guideline For Regulatory Approval/registration Of Amentioning

confidence: 99%

Section: Objectives Of the Anthelmintic Combination Guidelinementioning

confidence: 99%

“…and VICH guidelines for general efficacy of anthelmintics (Anonymous, 1999a(Anonymous, ,b, 2000a(Anonymous, ,c, 2001Vercruysse et al, 2001.…”

Section: Objectives Of the Anthelmintic Combination Guidelinementioning

confidence: 99%

Section: Dose Determination Data On the Anthelmintic Constituent Actimentioning

confidence: 99%

See 3 more Smart Citations

World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guideline: Anthelmintic combination products targeting nematode infections of ruminants and horses

Geary

Hosking

Skuce

et al. 2012

Veterinary Parasitology

100

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Veterinary Pharmacovigilance in the European Union

Woodward¹

2009

Veterinary Pharmacovigilance

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Effectiveness evaluation of several cattle anthelmintics via the fecal egg count reduction test

et al. 2009

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Utilizing groups of cograzed, naturally infected beef-type heifers, three fecal egg count reduction tests were conducted in the later months of 2007 at the University of Arkansas. Each test was 28 days in length consisting of individual animal fecal nematode egg counts and coprocultures. Both original and generic ivermectin injectable formulations were used in two of the tests at 0.2 mg/kg BW, with FECR percentages never exceeding 90% in either test. Oral fenbendazole was evaluated at 5 and 10 mg/kg BW, with FECR%'s exceeding 90% on all occasions, but with a precipitous drop when recently treated animals were treated at the lower dose. Evaluated in one test, injectable moxidectin given at 0.2 mg/kg BW resulted in egg count reductions of 96-92% (days 7 to 28). Also evaluated in one test, albendazole delivered orally at 10 mg/kg BW was 98% and 97% effective at 17 and 28 days post-treatment. For all tests, coprocultures conducted post-treatment contained only Cooperia spp. larvae (benzimidazole use), relatively unmodified percentages of Cooperia spp. and Haemonchus spp. larvae (ivermectin use), and primarily Cooperia spp. larvae with a small percentage of Haemonchus spp. larvae (moxidectin use).

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International harmonisation of Anthelmintic Efficacy Guidelines

Cited by 166 publications

References 1 publication

World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guideline: Anthelmintic combination products targeting nematode infections of ruminants and horses

World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guideline: Anthelmintic combination products targeting nematode infections of ruminants and horses

Veterinary Pharmacovigilance in the European Union

Effectiveness evaluation of several cattle anthelmintics via the fecal egg count reduction test

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