International Journal of Medicine and Biomedical Research

Lampiao, Fanuel

doi:10.14194/ijmbr.3.1.1

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…Neste ínterim, os resultados entre os estudos são divergentes (ILARIA, 1992;KILLICK, 2010;LAMPIAO, 2014;ZUKERMAN;. Todavia, alguns estudos apontam de forma concreta que o líquido pré-seminal pode liberar o esperma.…”

Section: Panorama Dos Artigos Estudadosunclassified

Síntese De Filmes De Pbat Para Aplicação Em Liberação Controlada De Fármacos

Costa¹,

Costa²,

Moreira³

et al. 2022

Ciências Da Saúde: Pluralidade Dos Aspectos Que Interferem Na Saúde Humana 10

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Section: Panorama Dos Artigos Estudadosunclassified

Síntese De Filmes De Pbat Para Aplicação Em Liberação Controlada De Fármacos

Costa¹,

Costa²,

Moreira³

et al. 2022

Ciências Da Saúde: Pluralidade Dos Aspectos Que Interferem Na Saúde Humana 10

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“…15 Various analytical methods are reported for the estimation of individual drug as well as in combination with other drugs. [16][17][18][19][20][21][22][23][24][25][26][27] Literature survey reveals that there is no any analytical method for simultaneous estimation of Metformin and Doxycycline till date. So, the objective of the proposed work was to develop and validate simple, accurate, precise and reproducible methods for the simultaneous estimation of Metformin and Doxycycline in bulk and synthetic mixture by UV-Spectrophotometric and RP-HPLC method.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of UV-Spectrophotometric and RP-HPLC method for simultaneous estimation of Metformin and Doxycycline in bulk and synthetic mixture

Mashru

Koshti

2021

J. Drug Delivery Ther.

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A simple, rapid, sensitive, accurate and precise UV spectrophotometric and isocratic RP-HPLC method have been developed for simultaneous estimation of Metformin and Doxycycline in bulk and synthetic mixture. Spectrophotometric estimation was done by two methods. First method was Q-absorbance ratio method, where two wavelengths 236 nm (λmax of Metformin) and 248 nm (Iso-absorptive point) were used. The second method was first derivative method. In this method the zero-crossing point of Metformin was selected at 282 nm and for Doxycycline, it was 232 nm. The solvent used was methanol in both the above UV-spectrophotometric methods. Metformin and Doxycycline showed good linearity in the series of 1-9 µg/ml and 2-20 µg/ml respectively by both the two methods with an excellent correlation coefficient (r2≥0.998). In RP-HPLC method, the chromatographic separation was achieved on Luna Phenomenex C18 (150 mmХ6 mm, 5 µm) analytical column. A mixture of Acetonitrile: Phosphate buffer (50 mM): Triethylamine (TEA): Tetrahydrofuran (THF) (30:66:2:2) pH adjusted to 2.1 with orthophosphoric acid was used as the mobile phase, at a flow rate of 1 ml/min and at detector wavelength 248 nm. The retention time of Metformin and Doxycycline was found to be 3.561±0.0017 and 5.574±0.0131 minutes respectively. A linear response was observed over the concentration range 4-64 µg/ml of Metformin and 5-80 µg/ml of Doxycycline. All the three methods were validated in accordance to ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The proposed methods were effectively utilized for the concurrent estimation of Metformin and Doxycycline in synthetic mixture. Keywords: Metformin, Doxycycline, Q-absorbance ratio method, First derivative method, RP-HPLC

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Coitus Interruptus

Ghislandi¹

2016

Encyclopedia of Evolutionary Psychological Science

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International Journal of Medicine and Biomedical Research

Cited by 10 publications

References 13 publications

Síntese De Filmes De Pbat Para Aplicação Em Liberação Controlada De Fármacos

Síntese De Filmes De Pbat Para Aplicação Em Liberação Controlada De Fármacos

Development and validation of UV-Spectrophotometric and RP-HPLC method for simultaneous estimation of Metformin and Doxycycline in bulk and synthetic mixture

Coitus Interruptus

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