Heletz–Ashdod oil field is the first oil deposit to have been discovered in the Eastern Mediterranean. This deposit has been exploited until the present despite its small reserves. However, this area’s tectonic–geodynamic and structural features must be studied more. Based on the integrated regional geological–geophysical analysis, it was proposed that the Heletz terrane, which includes this deposit, is the nodal structure of the Eastern Mediterranean. This terrane is a composite part of the earlier identified Mesozoic terrane belt (MTB). The Heletz terrane’s essential tectonic peculiarity is the MTB’s impact, rotating counterclockwise. Analysis of local geophysical data in this area (gravity, magnetic, and seismic) and regional thermal data examination testifies to the complex mosaic composition of the Heletz structure. It is proved that the crystal basement below the Heletz terrane is characterized by specific properties that do not coincide with the adjacent areas. Finally, a series of structural–paleogeographic and thickness formation maps of the Heletz–Ashdod oil field has been compiled. This investigation shed light on this area’s perspectives and searched other hydrocarbon deposits in the easternmost Mediterranean coastal and shelf zones.