International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants

Truong, Thérèse; Sauter, Wiebke; McKay, James; Hosgood, H. Dean; Gallagher, Carla J.; Amos, Christopher I.; Spitz, Margaret R.; Muscat, Joshua E.; Lazarus, Philip; Illig, Thomas; Wichmann, H‐Erich; Bickeböller, Heike; Risch, Angela; Dienemann, Hendrik; Zhang, Zuo‐Feng; Naeim, Behnaz Pezeshki; Yang, Ping; Zienolddiny, Shanbeh; Haugen, Aage; Marchand, Loı̈c Le; Hong, Yun Chul; Kim, Jin Hee; Duell, Eric J.; Andrew, Angeline S.; Kiyohara, Chikako; Shen, Hongbing; Matsuo, Keitaro; Suzuki, Takeshi; Seow, Adeline; Ng, Daniel P.K.; Lan, Qing; Заридзе, Давид; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Rudnai, Péter; Fabiánovà, Eleonóra; Constantinescu, Vali; Bencko, Vladimír; Foretová, Lenka; Janout, Vladimí­r; Caporaso, Neil E.; Albanês, Demetrius; Thun, Michael J.; Landi, Maria Teresa; Trubicka, Joanna; Lener, Marcin; Lubiński, Jan; Wang, Ying; Chabrier, Amélie; Boffetta, Paolo; Brennan, Paul; Hung, Rayjean J.

doi:10.1093/carcin/bgq001

Cited by 59 publications

(47 citation statements)

References 50 publications

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“…However, a recent GWA study investigating 10 potential lung cancer susceptibility variants failed to replicate this association [189], adding support to the lack of association for SNP +3954 in our data.…”

Section: Discussionsupporting

confidence: 70%

Allele-specific induction of IL1B −31 T/C promoter polymorphism by lung carcinogens

Hart

Haugen

Zienolddiny

2008

Mutation Research/Genetic Toxicology and Environmental Mutagene

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E\ .HQW +DUW 7KHVLV VXEPLWWHG IRU WKH GHJUHH RI Philosophiae DoctorProduced in co-operation with Unipub. The thesis is produced by Unipub merely in connection with the thesis defence. Kindly direct all inquiries regarding the thesis to the copyright holder or the unit which grants the doctorate. List of papersThe results from this project have been published in three papers which will be referred to in this thesis by the roman numerals I -III: Paper I

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Section: Discussionsupporting

confidence: 70%

Allele-specific induction of IL1B −31 T/C promoter polymorphism by lung carcinogens

Hart

Haugen

Zienolddiny

2008

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…Generally speaking, the number of studies that evaluated the relationship between MTHFR genetic polymorphism and LC risk is few and moreover their findings have been conflicting where some yielded an increased risk (Siemianowicz et al, 2003;Shen et al, 2005;Hung et al, 2007;Vineis et al, 2007;Arslan et al, 2011), a decreased risk (Jeng et al, 2003;Shi et al, 2003;Suzuki et al, 2007;Liu et al, 2009;Cui et al, 2011) or no association (Shen et al, 2001;Heijmans et al, 2003;Liu et al, 2008;Truong et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Allele and Genotype Frequencies of the Polymorphic Methylenetetrahydrofolate Reductase and Lung Cancer in ther Jordanian Population: a Case Control Study

Yousef

Shomaf²,

Said³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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of death after heart disease. A total of 6820 new cancer cases were registered by Jordan Cancer Registry in 2010, of these, 4921 cases (72.2%) were among Jordanians, and 1899 cases were non-Jordanians. Out of a total of 4921 new cases of cancer recorded amongst Jordanians in the 2010, of these, 2330 cases (48.1%) were males and 2519 cases (51.9%) were females (Jordan Cancer Registry, 2010). The rank order of the five most common cancers affecting Jordanians are: Breast, Colorectal, Lymphoma, Lung, and Prostate. The crude incidence rate of all cancer among Jordanians was 79.4 per 100,000 population (74.0 for males and 85.1S for females). The lung cancer agestandardized rate (ASR) for incidence/mortality in men (27.0/24.1) is substantially higher than women (4.1/3.7) (Ferlay et al., 2012).

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“…As the reason for few studies were performed and there were many meta-analysis related on TP53 gene polymorphism and cancer risk (Weng et al, 2012;Zhao et al, 2013), we could not use meta-analysis to analyze the relationship between TP53BP1 rs2602141 A/C polymorphism combined with TP53 gene polymorphism and cancer. In addition, Rudd et al (Rudd et al, 2006) and Truong et al (Truong et al, 2010) found that rs2602141 polymorphism was associated with lung cancer risk. However, because lack of sufficient data from these two studies, we could not include these studies in this metaanalysis.…”

Section: 2917 the P53-binding Protein 1 Rs2602141 A/c Snp And Cancermentioning

confidence: 99%

Association between the TP53BP1 rs2602141 A/C Polymorphism and Cancer Risk: A Systematic Review and Meta-Analysis

Liu

Zhang²,

Jiao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The p53-binding protein 1 (TP53BP1) gene may be involved in the development of cancer through disrupting DNA repair. However, investigation of associations between TP53BP1 rs2602141 A/C polymorphism and cancer have yielded contradictory and inconclusive outcomes. We therefore performed a meta-analysis to evaluate the association between the TP53BP1 rs2602141 A/C polymorphism and cancer susceptibility. Materials and Methods: Published literature from PubMed, Medline, the Cochrane Library, EMbase, Web of Science, Google (scholar), CBMDisc, Chongqing VIP database, and CNKI database were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models. Publication bias was estimated using funnel plots, Begg's and Egger's test. Results: A total of seven studies (3,018 cases and 5,548 controls) were included in the meta-analysis. Our results showed that the genotype distribution of TP53BP1 rs2602141 A/C was not associated with cancer risk overall. However, on subgroup analysis, we found that TP53BP1 rs2602141 A/C was associated with cancer risk within an allele model (A vs C, OR=1.14, 95%CI: 1.01-1.29) and a codominant model (AA vs CC, OR=1.36, 95%CI: 1.06-1.74) in Asians rather than in Caucasians. Subgroup analysis by cancer type, genotype, and with or without adjustment for controls showed no significant association. Conclusions: The findings suggested an association between rs2602141 A/C polymorphism in TP53BP1 gene and increased risk of cancer in Asians.

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International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants

Abstract: This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.

Cited by 59 publications

References 50 publications

Allele-specific induction of IL1B −31 T/C promoter polymorphism by lung carcinogens

Allele-specific induction of IL1B −31 T/C promoter polymorphism by lung carcinogens

Allele and Genotype Frequencies of the Polymorphic Methylenetetrahydrofolate Reductase and Lung Cancer in ther Jordanian Population: a Case Control Study

Association between the TP53BP1 rs2602141 A/C Polymorphism and Cancer Risk: A Systematic Review and Meta-Analysis

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